Anti-inflammatory phomalichenones from an endolichenic fungus Phoma sp

  • J Antibiot (Tokyo). 2018 Aug;71(8):753-756. doi: 10.1038/s41429-018-0058-7.
Jong Won Kim  1 ,  Wonmin Ko  2 ,  Eun Kim  1  3 ,  Gil Soo Kim  1  3 ,  Gwi Ja Hwang  1  3 ,  Sangkeun Son  1 ,  Min-Hye Jeong  4 ,  Jae-Seoun Hur  4 ,  Hyuncheol Oh  2 ,  Sung-Kyun Ko  1  3 ,  Jae-Hyuk Jang  5  6 ,  Jong Seog Ahn  7  8
Affiliations
  • 1. Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea.
  • 2. College of Pharmacy, Wonkwang University, Iksan, 54538, Republic of Korea.
  • 3. Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34113, Republic of Korea.
  • 4. Korean Lichen Research Institute, Sunchon National University, Suncheon, 57922, Republic of Korea.
  • 5. Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea. [email protected].
  • 6. Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34113, Republic of Korea. [email protected].
  • 7. Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea. [email protected].
  • 8. Department of Biomolecular Science, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, 34113, Republic of Korea. [email protected].
PMID: 29700423 DOI: 10.1038/s41429-018-0058-7
Abstract

Four new compounds, phomalichenones A-D (1-4), and seven known compounds (5-11) were isolated from the cultures of an endolichenic fungus Phoma sp. EL002650. Their structures were determined by the analysis of their spectroscopic data (NMR and MS). Compounds 1 and 6 inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. In addition, compound 1 diminished the protein expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and decreased the mRNA expression levels of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin(IL)-1β, and IL-6.

Products