BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection

  • Front Immunol. 2019 Mar 29;10:617. doi: 10.3389/fimmu.2019.00617.
Xueping Yu  1  2 ,  Yijuan Zheng  1 ,  Richeng Mao  2 ,  Zhijun Su  1 ,  Jiming Zhang  2
Affiliations
  • 1. Department of Infectious Diseases, First Hospital of Quanzhou, Fujian Medical University, Quanzhou, China.
  • 2. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
PMID: 30984188 DOI: 10.3389/fimmu.2019.00617
Abstract

B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense research. However, the mechanisms of the BTLA and the BTLA/HVEM signaling pathway in human diseases remain unclear. This review describes the research milestones of BTLA and HVEM in chronological order and their role in chronic HBV Infection.

Keywords
B and T lymphocyte attenuator; T lymphocyte; hepatitis B virus; herpes virus entry mediator; milestones.
Products