AOC3 Protein, Human (HEK293, His)
Based on 1 Customer Validation
As a cell adhesion molecule, AOC3 protein plays a key role in lymphocyte extravasation and recycling by promoting the binding of lymphocytes to peripheral lymph node vascular endothelial cells, independent of L-selectin. In addition to its role in cell adhesion, AOC3 exhibits semicarbazide-sensitive monoamine oxidase activity, contributing to its enzymatic function. AOC3 Protein, Human (HEK293, His) is the recombinant human-derived AOC3 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
As a cell adhesion molecule, AOC3 protein plays a key role in lymphocyte extravasation and recycling by promoting the binding of lymphocytes to peripheral lymph node vascular endothelial cells, independent of L-selectin. In addition to its role in cell adhesion, AOC3 exhibits semicarbazide-sensitive monoamine oxidase activity, contributing to its enzymatic function. AOC3 Protein, Human (HEK293, His) is the recombinant human-derived AOC3 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
AOC3, or amine oxidase, copper-containing 3, functions as a cell adhesion protein crucial for lymphocyte extravasation and recirculation. It facilitates the binding of lymphocytes to peripheral lymph node vascular endothelial cells in a manner independent of L-selectin. Additionally, AOC3 exhibits semicarbazide-sensitive monoamine oxidase (SSAO) activity, suggesting its involvement in the oxidative deamination of primary amines. Beyond its role in immune cell interactions, AOC3 may also play a part in adipogenesis, contributing to the complex processes underlying the formation and development of adipose tissue.
Verified Bioactivity
The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
Q16853 (R28-N763)
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Molecular Construction
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N-term
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AOC3 (R28-N763)
Accession # Q16853 -
6*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
AOC3; Copper Amine Oxidase; Amine Oxidase Copper Containing 3; SSAO; VAP-1; Amine Oxidase, Copper Containing 3 (Vascular Adhesion Protein 1); VAP1; Amine Oxidase Copper-Containing 3; HPAO; Placenta Copper Monamine Oxidase; Semicarbazide-Sensitive Amine Ox
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AA Sequence
RGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQAPKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
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Predicted Molecular Mass
82.6 kDa
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Molecular Weight
Approximately 90-110 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 20 mM Tris-HCl, 500 mM NaCl, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (239 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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