AOC3 - amine oxidase copper containing 3 Gene

Also Known as HPAO; SSAO; VAP1; VAP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8639

About AOC3

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:42,851,199-42,858,124 (from NCBI)

This gene has 7 transcripts (splice variants), 312 orthologues and 2 paralogues. Biased expression in fat (RPKM 252.0), lung (RPKM 69.7) and 8 other tissues.

Summary

This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as Monoamine Oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

AOC3 Products (3)

mRNA	Protein	Name
NM_001277731.2	NP_001264660.1	membrane primary amine oxidase isoform 2
NM_001277732.2	NP_001264661.1	membrane primary amine oxidase isoform 3
NM_003734.4	NP_003725.1	membrane primary amine oxidase isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	16046623	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	16046623	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16046623	GOA
NOT enables primary methylamine oxidase activity	IDA IDA: Inferred from direct assay	23349812	GOA
enables primary methylamine oxidase activity	IDA IDA: Inferred from direct assay	9653080	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23349812	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	23349812	GOA
enables quinone binding	IDA IDA: Inferred from direct assay	9653080	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amine metabolic process	IDA IDA: Inferred from direct assay	9653080	GOA
involved in cell adhesion	IDA IDA: Inferred from direct assay	9653080	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	23474851	GOA
located in cell surface	IDA IDA: Inferred from direct assay	9653080	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23349812	GOA
located in early endosome	IDA IDA: Inferred from direct assay	23474851	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23474851	GOA
located in membrane	IDA IDA: Inferred from direct assay	9653080	GOA
located in microvillus	IDA IDA: Inferred from direct assay	23349812	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9653080	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AOC3 Protein Structure

Cu_amine_oxidN2

Cu_amine_oxidN3

Cu_amine_oxid

0
200
400
600
763 a.a.

Protein Preferred Names	Protein Names
membrane primary amine oxidase	amine oxidase, copper containing 3 (vascular adhesion protein 1)

AOC3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AOC3	Q16853	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	AOC3	Q16853	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	AOC3	Q16853	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	AOC3	Q16853	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	AOC3	Q16853	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	AOC3	Q16853	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	AOC3	Q16853	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	AOC3	Q16853	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	AOC3	Q16853	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	AOC3	Q16853	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	AOC3	Q16853	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	AOC3	Q16853	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	AOC3	Q16853	CLDN9	Homo sapiens	O95484	Y2H Prey Pooling	32296183
Intra	AOC3	Q16853	CLDN9	Homo sapiens	O95484	Y2H Array	32296183
Intra	AOC3	Q16853	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	AOC3	Q16853	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	AOC3	Q16853	DARS2	Homo sapiens	Q6PI48	Validated Y2H	32296183
Intra	AOC3	Q16853	DARS2	Homo sapiens	Q6PI48	Y2H Array	32296183
Intra	AOC3	Q16853	DARS2	Homo sapiens	Q6PI48	Y2H Prey Pooling	32296183
Intra	AOC3	Q16853	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	AOC3	Q16853	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	AOC3	Q16853	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	AOC3	Q16853	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	AOC3	Q16853	STX1A	Homo sapiens	Q16623	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AOC3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70065	AOC3 Protein, Human (HEK293, His)	Q16853 (R28-N763)	≥ 95%, as determined by reducing SDS-PAGE.

AOC3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89621	VAP-1 Antibody (YA8965)	WB, ICC/IF, IF-Tissue, FC, IP	human

Related Diseases

Diseases	Alias
Diabetic Angiopathy	Diabetic Angiopathies Diabetic Peripheral Angiopathy Diabetic Vascular Disorder
Diabetes Mellitus	Diabetes
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Type 1 Diabetes Mellitus 23	Diabetes Mellitus, Insulin-Dependent, 23 Iddm23 T1D23 Insulin-Dependent Diabetes Mellitus 23
Immunodeficiency 17	IMD17 Cd3-Gamma Deficiency Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive Combined Immunodeficiency Due To Cd3gamma Deficiency Immunodeficiency 17, Cd3 Gamma Deficient Cd3gamma Deficiency Immunodeficiency, Type 17
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Hereditary Cystatin C Amyloid Angiopathy Cerebral Amyloid Angiopathy, Familial Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Miyoshi Muscular Dystrophy 3	MMD3 Miyoshi Myopathy 3 Distal Anoctaminopathy Miyoshi Muscular Dystrophy Type 3 Dystrophy, Muscular, Miyoshi, Type 3
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Microvascular Complications Of Diabetes 5	Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 5 MVCD5 Retinopathy, Diabetic Diabetic Nephropathy Retinopathy, Diabetic, Susceptibility To Retinal Abnormality - Diabetes-Related
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Dermatitis, Atopic, 7	ATOD7 Dermatitis, Atopic, Susceptibility To, 7 Atopic Dermatitis 7 Dermatitis, Atopic 7
Type 1 Diabetes Mellitus 8	Diabetes Mellitus, Insulin-Dependent, 8 Iddm8 Insulin-Dependent Diabetes Mellitus 8 T1D8 Insulin-Dependent Diabetes Mellitus-8
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00773	AOC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17943	Aoc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24414	Aoc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99323	Timolumab	Inhibitor	98.56%	Unkown
HY-P99526	Vapaliximab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AOC3	RGD	RGD:62058
Canis familiaris	AOC3	VGNC	VGNC:37949
Mus musculus	AOC3	MGD	MGI:1306797
Others	AOC3	NCBI