Cadherin-13 Protein, Rat (HEK293, His)
Cadherin-13 Protein is an atypical member of the cadherin family, devoid of a transmembrane domain and anchored to the exterior surface of the plasma membrane via a glycosylphosphatidylinositol anchor. And it exhibits a preference for homophilic interactions, fostering connections between neighboring cells and potentially playing a role in cell type sorting. Cadherin-13 may act as negative regulators of neural cell growth. Moreover, it may act rather as a signalling receptor participating in recognition of the environment and regulation of cell motility, proliferation and phenotype. Cadherin-13 Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-13 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Rat
- Source: HEK293
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Cadherin-13 Protein is an atypical member of the cadherin family, devoid of a transmembrane domain and anchored to the exterior surface of the plasma membrane via a glycosylphosphatidylinositol anchor. And it exhibits a preference for homophilic interactions, fostering connections between neighboring cells and potentially playing a role in cell type sorting. Cadherin-13 may act as negative regulators of neural cell growth. Moreover, it may act rather as a signalling receptor participating in recognition of the environment and regulation of cell motility, proliferation and phenotype. Cadherin-13 Protein, Rat (HEK293, His) is the recombinant rat-derived Cadherin-13 protein, expressed by HEK293 , with C-His labeled tag.
Background
Cadherin-13 is an atypical member of the cadherin family, devoid of a transmembrane domain and anchored to the exterior surface of the plasma membrane via a glycosylphosphatidylinositol anchor. And it exhibits a preference for homophilic interactions, fostering connections between neighboring cells and potentially playing a role in cell type sorting. Cadherin-13 may act as negative regulators of neural cell growth. Cadherin-13 is highly expressed in nervous and cardiovascular system (in endothelial and smooth muscle cells). Thereby, it may facilitate progression of proliferative vascular disorders such as atherosclerosis, restenosis and tumor angiogenesis. Moreover, it may act rather as a signalling receptor participating in recognition of the environment and regulation of cell motility, proliferation and phenotype. Cadherin-13-dependent activation of PI3K/Akt/GSK3β signalling axis protects endothelial cells from oxidative stress-induced apoptosis.
Technical Parameters
-
Species Rat
-
Source HEK293
-
Tag C-His
-
Accession
Q8R490 (A22-A692)
-
Molecular Construction
-
N-term
-
Cadherin-13 (A22-A692)
Accession # Q8R490 -
His
-
C-term
-
-
Protein Length
Partial
-
Synonyms
CDH13; Cadherin-13; Cadherin 13; T-Cad; CDHH; P105; T-Cadherin; Cadherin 13, H-Cadherin (Heart); H-Cadherin (Heart); Truncated Cadherin; Heart Cadherin; H-Cadherin
-
AA Sequence
AGDLDCTPGFQQKVLHIHQPAEFIEDQPVLNLTFSDCKGNKKLHYEVSSPYFKVNSDGTLVAVRNITAVGRTLFVHARTPHAEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPEGSKFRLTGKGVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLFVETTDASGRTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIVIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPATGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTKQENISVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLSINPINGTVDTTAVLDRESPFVHNSVYTALFLAIDSGNPPATGTGTLMITLEDVNDNAPVIYPTVAEVCDDARNLSVVILGASDKDLHPNTDPFKFEIHKQTVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSCKNSKVDCNAA
-
Predicted Molecular Mass
74.9 kDa
-
Molecular Weight
Approximately 117 kDa & 95 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
-
Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
