EPHA5 Protein, Cynomolgus (518a.a, HEK293, His)
EPHA5 Protein, Cynomolgus (518a.a, HEK293, His) is the recombinant cynomolgus-derived EPHA5 protein, expressed by HEK293, with C-His tag.
- Species: Cynomolgus
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
EPHA5 Protein, Cynomolgus (518a.a, HEK293, His) is the recombinant cynomolgus-derived EPHA5 protein, expressed by HEK293, with C-His tag.
Background
Erythropoietin-producing human liver cancer receptors (Eph receptors) are the largest subgroup of receptor tyrosine kinases. Eph receptors were originally found to regulate embryogenesis by fine-tuning cell adhesion, localization, and migration, particularly in the nervous system. EPHA5 is a member of the Eph receptor and is involved in a variety of biological activities, including tumorigenesis and the progression of different cancers. EPHA5 enhances the invasion and migration of esophageal squamous cell carcinoma through epithelial-mesenchymal transformation by activating the Wnt/β-catenin pathway[1][2][3].
Technical Parameters
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Species Cynomolgus
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Source HEK293
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Tag C-His
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Accession
XP_005555256.1 (S56-P573)
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Gene ID102138762
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Protein Length
Partial
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Synonyms
EPHA5; EHK-1; EPH Receptor A5; EK7; TYRO4; Epididymis Secretory Sperm Binding Protein; EHK1; Tyrosine-Protein Kinase Receptor EHK-1; Hek7; Receptor Protein-Tyrosine Kinase HEK7; CEK7; Receptor Protein-Tyrosine Kinase; Ephrin Type-A Receptor 5; EphA5; EPH
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AA Sequence
SPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNINETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIP
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Predicted Molecular Mass
59 kDa
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Molecular Weight
Approximately 76 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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