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  4. EPHA5 Protein, Cynomolgus (518a.a, HEK293, His)

EPHA5 Protein, Cynomolgus (518a.a, HEK293, His)

Art. -Nr.: HY-P703732
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EPHA5 Protein, Cynomolgus (518a.a, HEK293, His) is the recombinant cynomolgus-derived EPHA5 protein, expressed by HEK293, with C-His tag.

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Beschreibung

EPHA5 Protein, Cynomolgus (518a.a, HEK293, His) is the recombinant cynomolgus-derived EPHA5 protein, expressed by HEK293, with C-His tag.
Background

Erythropoietin-producing human liver cancer receptors (Eph receptors) are the largest subgroup of receptor tyrosine kinases. Eph receptors were originally found to regulate embryogenesis by fine-tuning cell adhesion, localization, and migration, particularly in the nervous system. EPHA5 is a member of the Eph receptor and is involved in a variety of biological activities, including tumorigenesis and the progression of different cancers. EPHA5 enhances the invasion and migration of esophageal squamous cell carcinoma through epithelial-mesenchymal transformation by activating the Wnt/β-catenin pathway[1][2][3].
Species

Cynomolgus
Source

HEK293
Tag

C-His
Accession

XP_005555256.1 (S56-P573)
Gene ID

102138762
Protein Length

Partial
Synonyms
EHK-1; EK7; BSK; EHK1; HEK7; TYRO4; EphA5; Rek7; TYRO4HEK7CEK7
AA Sequence

SPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNINETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIP

Predicted Molecular Mass
59 kDa
Molekulargewicht

Approximately 76 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Reinheit

≥ 95%, as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Dokumentation
Handling Instructions (2659 KB)

EPHA5 Protein, Cynomolgus (518a.a, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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