RNF14 Protein, Human

RNF14 Protein serves as a pivotal E3 ubiquitin-protein ligase in the RNF14-RNF25 translation quality control pathway, specifically activated when ribosomes stall during translation. In response to ribosome collision sensed by GCN1, RNF14 is recruited to stalled ribosomes, catalyzing the ubiquitination and subsequent degradation of translation factors, with a primary target being EEF1A1/eEF1A. This orchestrated process extends to the ubiquitination and degradation of other translation factors, including ETF1/eRF1 and several ribosomal proteins, such as RPL0, RPL1, RPL12, RPS13, and RPS17. Independently of its role in translational control, RNF14 assumes a regulatory role in Wnt signaling by interacting with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3, and TCF7L2/TCF4). Furthermore, it may act as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription, underscoring its multifunctional role in cellular processes.