TXNDC5 Protein, Human (GST)

TXNDC5 Protein, an endoplasmic reticulum lumen-based disulfide isomerase, crucially aids in forming disulfide bonds for protein stability and function. Its ability to reduce disulfide bonds in insulin highlights its role in intricate protein folding processes. TXNDC5's functional attributes make it a key player in preserving the structural integrity of endoplasmic reticulum proteins, contributing to cellular homeostasis. TXNDC5 Protein, Human (GST) is the recombinant human-derived TXNDC5 protein, expressed by E. coli , with N-GST labeled tag. The total length of TXNDC5 Protein, Human (GST) is 324 a.a., with molecular weight of ~63.2 kDa.

TXNDC5, a protein disulfide isomerase situated within the endoplasmic reticulum lumen, plays a pivotal role in facilitating the formation of disulfide bonds crucial for protein stability and function. Notably, it exhibits the ability to reduce disulfide bonds in insulin, underscoring its significance in the intricate processes of protein folding and maturation. The functional attributes of TXNDC5 emphasize its role as a key player in maintaining the structural integrity of proteins within the endoplasmic reticulum, thereby contributing to cellular homeostasis.

Human

E. coli

N-GST

Q8NBS9 (1M-324L)

81567  [NCBI]

MEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAKDEL

Approximately 63.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized after extensive dialysis against solution in Tris-based buffer, 50% glycerol.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.