TXNDC5 - thioredoxin domain containing 5 Gene

Also Known as HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81567

About TXNDC5

Cytogenetic location: 6p24.3 Genomic coordinates (GRCh38): 6:7,881,517-7,910,788 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 13 paralogues. Ubiquitous expression in urinary bladder (RPKM 151.7), colon (RPKM 127.4) and 25 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from Apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]

TXNDC5 Products (2)

mRNA	Protein	Name
NM_001145549.4	NP_001139021.1	thioredoxin domain-containing protein 5 isoform 3
NM_030810.5	NP_110437.2	thioredoxin domain-containing protein 5 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21057456	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TXNDC5 Protein Structure

Thioredoxin

0
100
200
300
400
432 a.a.

Protein Preferred Names	Protein Names
thioredoxin domain-containing protein 5	ER protein 46

TXNDC5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TXNDC5	Q8NBS9	PRDX4	Homo sapiens	Q13162	Enzymatic Study	21057456
Intra	TXNDC5	Q8NBS9	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	TXNDC5	Q8NBS9	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	TXNDC5	Q8NBS9	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TXNDC5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71609	TXNDC5 Protein, Human (GST)	Q8NBS9-2 (M1-L324)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 33	DEE33 Epileptic Encephalopathy, Early Infantile, 33 Eiee33 Developmental And Epileptic Encephalopathy, 33 Early Infantile Epileptic Encephalopathy 33 Encephalopathy, Epileptic, Early Infantile, Type 33

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122895	E64FC26		98.48%	Unkown
HY-112056	DIM-C-pPhCO2Me		99.47%	Unkown
HY-122895A	(E/Z)-E64FC26		99.80%	Unkown
HY-RS15294	TXNDC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17353	Txndc5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23807	Txndc5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TXNDC5	VGNC	VGNC:107007
Macaca mulatta	TXNDC5	VGNC	VGNC:79304
Mus musculus	TXNDC5	MGD	MGI:2145316
Felis catus	TXNDC5	VGNC	VGNC:102543
Canis familiaris	TXNDC5	VGNC	VGNC:48015
Rattus norvegicus	TXNDC5	RGD	RGD:2323973
Others	TXNDC5	NCBI