2. Metabolic Enzyme/Protease
  3. RIO Kinase
  4. RIOK2-IN-1

RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression.

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RIOK2-IN-1

RIOK2-IN-1 화학구조

CAS No. : 1088216-72-1

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RIOK2-IN-1 Related Antibodies

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제품 설명

RIOK2-IN-1 (com 4) is a potent and selective RIOK2 inhibitor (Kd=150 nM), but has low cellular activity (IC50=14,600 nM). RIOK2 is an atypical kinase associated with a variety of human cancers and is involved in ribosome maturation and cell cycle progression. The small molecule inhibitor CQ211 (HY-147655), an improvement of RIOK2-IN-1 as the lead compound, has good in vivo and in vitro activity, inhibits the proliferation of MKN-1 and HT-29 cancer cells, and can xenograft MKN in mice -1 model inhibits tumor progression[1].

IC50 & Target

RIOK2

 

Cellular Effect
Cell Line Type Value Description References
HT-29 IC50
>8 μM
Compound: 4
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
[PMID: 35584513]
MKN-1 IC50
>8 μM
Compound: 4
Antiproliferative activity against human MKN-1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MKN-1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
[PMID: 35584513]
분자량

276.33

화학식

C18H16N2O
CAS No.
SMILES

O=C(CC1=CC2=C(C=CC=C2)C=C1)NC3=NC=CC(C)=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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RIOK2-IN-1 Related Classifications

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Keywords:

RIOK2-IN-11088216-72-1RIO KinaseRright open reading frame KinaseAtypical kinasesribosome maturationand cell cycle progressionInhibitorinhibitorinhibit

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상품명:
RIOK2-IN-1
Cat. No.:
HY-156792
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