(S,R,S)-AHPC-Me-C8-NHS ester

Cat. No.: HY-185142 Purity: 99.89%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

The (S,R,S)-AHPC-Me-C8-NHS ester is an E3 ubiquitin ligase VHL ligand, used to recruit the VHL protein. The (S,R,S)-AHPC-Me-C8-NHS ester can be linked to the target protein ligand through a linker to form a PROTAC.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Me-C8-NHS ester Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Biological Activity
Purity & Documentation
Customer Review

Description

IC₅₀ & Target

VHL

Molecular Weight

725.89

Formula

C₃₇H₅₁N₅O₈S

Appearance

Solid

Color

White to off-white

SMILES

CC(C)([C@H](NC(CCCCCCCCC(ON1C(CCC1=O)=O)=O)=O)C(N2[C@@H](C[C@H](C2)O)C(N[C@@H](C)C3=CC=C(C=C3)C4=C(N=CS4)C)=O)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (68.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3776 mL	6.8881 mL	13.7762 mL
5 mM	0.2755 mL	1.3776 mL	2.7552 mL
10 mM	0.1378 mL	0.6888 mL	1.3776 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (245 KB) SDS (252 KB)

COA (252 KB) HNMR (315 KB) RP-HPLC (158 KB) LCMS (230 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3776 mL	6.8881 mL	13.7762 mL	34.4405 mL
	5 mM	0.2755 mL	1.3776 mL	2.7552 mL	6.8881 mL
	10 mM	0.1378 mL	0.6888 mL	1.3776 mL	3.4440 mL
	15 mM	0.0918 mL	0.4592 mL	0.9184 mL	2.2960 mL
	20 mM	0.0689 mL	0.3444 mL	0.6888 mL	1.7220 mL
	25 mM	0.0551 mL	0.2755 mL	0.5510 mL	1.3776 mL
	30 mM	0.0459 mL	0.2296 mL	0.4592 mL	1.1480 mL
	40 mM	0.0344 mL	0.1722 mL	0.3444 mL	0.8610 mL
	50 mM	0.0276 mL	0.1378 mL	0.2755 mL	0.6888 mL
	60 mM	0.0230 mL	0.1148 mL	0.2296 mL	0.5740 mL