SARS-CoV-2-IN-29 disodium
SARS-CoV-2-IN-29 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-29 disodium exhibits antiviral activity with IC50s of 1.5 μM and 1.6 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-29 disodium induces liposomal membrane disruption with an EC50 value of 3.0 μM.
For research use only. We do not sell to patients.
- Formula: C58H46Na2O8P2
- Molecular Weight:978.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 3.0 μM (viral liposome, SARS-CoV-2)[1]
SARS-CoV-2-IN-29 (CP024) disodium inhibits SARS-CoV-2 (IC50=1.6 μM) with low cytotoxicity (Caco2 cells, CC50=77.4 μM)[1].
SARS-CoV-2-IN-29 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 1.5 μM[1].
SARS-CoV-2-IN-29 disodium suppresses varies enveloped viruses activity with IC50s of 2.1 μM (influenza A virus, IAV), 2.1 μM (measles virus, MeV), 1.8 μM (herpes simplex viruses, HSV-1), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
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Concentration:0, 0.23, 0.93, 3.75, 15 μM
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Incubation Time:2 hours; determined infection rates on day 2
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Result:Inhibited SARS-CoV-2 infection activity to Caco2 cells.
Chemical Information
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Molecular Weight 978.91
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Formula C58H46Na2O8P2
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SMILES
CC(C=C1)=CC=C1COP(OC(C2=C3C4C5=CC(C6CC7C8=C6C=CC=C8)=C7C=C5C2C4)=C(C9C%10=C(C%11C9)C=C%12C(C%13C%14=C(C%12C%13)C=CC=C%14)=C%10)C%11=C3OP(OCC%15=CC=C(C=C%15)C)(O[Na])=O)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)