1. Anti-infection
  2. SARS-CoV
  3. SARS-CoV-2-IN-30 disodium

SARS-CoV-2-IN-30 disodium 

Cat. No.: HY-151278A
Handling Instructions

SARS-CoV-2-IN-30 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-30 disodium exhibits antiviral activity with IC50s of 0.6 μM and 6.9 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-30 disodium induces liposomal membrane disruption with an EC50 value of 6.9 μM.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-30 disodium Chemical Structure

SARS-CoV-2-IN-30 disodium Chemical Structure

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Description

SARS-CoV-2-IN-30 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-30 disodium exhibits antiviral activity with IC50s of 0.6 μM and 6.9 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-30 disodium induces liposomal membrane disruption with an EC50 value of 6.9 μM[1].

IC50 & Target

IC50: 6.9 μM (viral liposome, SARS-CoV-2)[1]

In Vitro

SARS-CoV-2-IN-30 (CP025) disodium inhibits SARS-CoV-2 (IC50=6.9 μM) with few cytotoxicity (Caco2 cells, CC50=106.1 μM)[1].
SARS-CoV-2-IN-30 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 0.6 μM[1].
SARS-CoV-2-IN-30 disodium suppresses varies enveloped viruses activity with IC50s of 6.1 μM (respiratory syncytial virus, RSV), 3.2 μM (influenza A virus, IAV), 7.0 μM (measles virus, MeV), 1.1 μM (herpes simplex viruses, HSV-1), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
Concentration: 0, 0.23, 0.93, 3.75, 15 μM
Incubation Time: 2 hours; determined infection rates on day 2
Result: Inhibited SARS-CoV-2 infection activity to Caco2 cells.
In Vivo

SARS-CoV-2-IN-30 (CP025) disodium (150 μM, 50 μL; intranasal route; for 2-5 d) shows antiviral activity in vivo against respiratory syncytial virus (RSV) and SARS-CoV-2 in BALB/cJ mice or K18-hACE2 mice, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Respiratory syncytial virus (RSV) infection of BALB/cJ mice and SARS-CoV-2 infection of K18-hACE2 mice[1]
Dosage: 150 μM, 50 μL
Administration: Intranasal route; single dose; sacrificed BALB/cJ mice on day 5; treated K18-hACE2 mice once again after 7 h and sacrificed mice on day 2
Result: Reduced viral load in the lungs of SARS-CoV-2-infected mice.
Completely abolished SARS-CoV-2 infection of all tested mice without changing body weight of mice.
Molecular Weight

1006.96

Formula

C60H50Na2O8P2

SMILES

CCC(C=C1)=CC=C1COP(OC(C2=C3C4C5=CC(C6CC7C8=C6C=CC=C8)=C7C=C5C2C4)=C(C9C%10=C(C%11C9)C=C%12C(C%13C%14=C(C%12C%13)C=CC=C%14)=C%10)C%11=C3OP(OCC%15=CC=C(C=C%15)CC)(O[Na])=O)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Product Name:
SARS-CoV-2-IN-30 disodium
Cat. No.:
HY-151278A
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