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Cat. No.: HY-151278A

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SARS-CoV-2-IN-30 disodium

SARS-CoV-2-IN-30 disodium is a two-armed diphosphate ester with benzene system and molecular tweezers. SARS-CoV-2-IN-30 disodium exhibits antiviral activity with IC₅₀s of 0.6 μM and 6.9 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-30 disodium induces liposomal membrane disruption with an EC₅₀ value of 6.9 μM.

For research use only. We do not sell to patients.

Formula: C₆₀H₅₀Na₂O₈P₂
Molecular Weight:1006.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

SARS-CoV-2-IN-30 disodium Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 6.9 μM (viral liposome, SARS-CoV-2)^[1]

In Vitro

SARS-CoV-2-IN-30 (CP025) disodium inhibits SARS-CoV-2 (IC₅₀=6.9 μM) with few cytotoxicity (Caco2 cells, CC₅₀=106.1 μM)^[1].
SARS-CoV-2-IN-30 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC₅₀ value of 0.6 μM^[1].
SARS-CoV-2-IN-30 disodium suppresses varies enveloped viruses activity with IC₅₀s of 6.1 μM (respiratory syncytial virus, RSV), 3.2 μM (influenza A virus, IAV), 7.0 μM (measles virus, MeV), 1.1 μM (herpes simplex viruses, HSV-1), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
Concentration:

0, 0.23, 0.93, 3.75, 15 μM
Incubation Time:

2 hours; determined infection rates on day 2
Result:

Inhibited SARS-CoV-2 infection activity to Caco2 cells.

In Vivo

SARS-CoV-2-IN-30 (CP025) disodium (150 μM, 50 μL; intranasal route; for 2-5 d) shows antiviral activity in vivo against respiratory syncytial virus (RSV) and SARS-CoV-2 in BALB/cJ mice or K18-hACE2 mice, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Respiratory syncytial virus (RSV) infection of BALB/cJ mice and SARS-CoV-2 infection of K18-hACE2 mice^[1]
Dosage:

150 μM, 50 μL
Administration:

Intranasal route; single dose; sacrificed BALB/cJ mice on day 5; treated K18-hACE2 mice once again after 7 h and sacrificed mice on day 2
Result:

Reduced viral load in the lungs of SARS-CoV-2-infected mice.
Completely abolished SARS-CoV-2 infection of all tested mice without changing body weight of mice.

Chemical Information

Molecular Weight 1006.96
Formula C₆₀H₅₀Na₂O₈P₂
SMILES

CCC(C=C1)=CC=C1COP(OC(C2=C3C4C5=CC(C6CC7C8=C6C=CC=C8)=C7C=C5C2C4)=C(C9C%10=C(C%11C9)C=C%12C(C%13C%14=C(C%12C%13)C=CC=C%14)=C%10)C%11=C3OP(OCC%15=CC=C(C=C%15)CC)(O[Na])=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tatjana Weil, et al. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022, XXXX, XXX, XXX-XXX.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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