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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
57 Results for "
KDM4
" in MedChemExpress (MCE) Product Catalog:
Products (57)
57 Results for "KDM4" in MCE Product Catalog:
Cat. No.: HY-RS07214
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KDM4B Human Pre-designed siRNA Set A contains three designed siRNAs for KDM4B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07215
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KDM4C Human Pre-designed siRNA Set A contains three designed siRNAs for KDM4C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07216
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KDM4D Human Pre-designed siRNA Set A contains three designed siRNAs for KDM4D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07217
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KDM4E Human Pre-designed siRNA Set A contains three designed siRNAs for KDM4E gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W013381
CAS No.: 50530-12-6
Synonyms: Decanoic acid, 10-bromo-
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10-Bromodecanoic acid (Decanoic acid, 10-bromo-) is a linker that can be used in the synthesis of PROTACs, such as PROTAC KDM4 degrader-1 (HY-173135) .
Cat. No.: HY-148807A
CAS No.: 2908753-10-4
Synonyms: QC8222; TACH 101
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Zavondemstat (QC8222; TACH 101) L-lysine is an orally active pan-KDM4 inhibitor, with a IC50 ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat L-lysine induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat L-lysine suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat L-lysine can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .
Cat. No.: HY-148807B
Purity: 97.51%
Synonyms: (S)-QC8222 free base; (S)-TACH 101 free base
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(S)-Zavondemstat is the S-enantiomer of Zavondemstat (HY-148807). Zavondemstat is an inhibitor of histone lysine demethylase 4D (KDM4D) with antineoplastic activity [1] .
Cat. No.: HY-119730
CAS No.: 1428962-73-5
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Tripartin is an inhibitor of histone demethylase. Tripartin inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells .
Cat. No.: HY-148807C
CAS No.: 2908753-07-9
Synonyms: QC8222 sodium; TACH 101 sodium
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Zavondemstat (QC8222; TACH 101) sodium is an orally active pan-KDM4 inhibitor, with a IC50 ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat sodium induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat sodium suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat sodium can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer .
Cat. No.: HY-157408
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KDM4D-IN-3 (compound 1) is a small-molecule epigenetic inhibitor target at KDM4D with an IC50 value of 4.8 μM .
Cat. No.: HY-126207
CAS No.: 726201-10-1
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CBN209350 is a selective KDM4 inhibitor with an IC50 of 4 μM. CBN209350 exerts antiproliferative effects on prostate cancer cells. CBN209350 can be used for the research of prostate cancer .
Cat. No.: HY-RS17467
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Kdm4a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm4a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23925
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Kdm4a Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm4a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20046
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Kdm4d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm4d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23577
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Kdm4b Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm4b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26549
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Kdm4d Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm4d gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-104048R
CAS No.: 1851373-36-8
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QC6352 (Standard) is the analytical standard of QC6352 (HY-104048). This product is intended for research and analytical applications. QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC50s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC50 of 750 nM (KDM5B) .
Cat. No.: HY-100760S
CAS No.: 2300178-70-3
Synonyms: Xanthothricin-13C4; Toxoflavine-13C4; PKF-118-310-13C4
Cat. No.: HY-100760R
CAS No.: 84-82-2
Synonyms: Xanthothricin (Standard); Toxoflavine (Standard); PKF-118-310 (Standard)
Toxoflavin (Standard) is the analytical standard of Toxoflavin. This product is intended for research and analytical applications. Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor and antibiotic activity[1][2].
Cat. No.: HY-116796
CAS No.: 23705-85-3
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KDM4C-IN-2 is a histone lysine demethylase KDM4C (JMJD2C) inhibitor with an IC50 of 147 μM and a Ki of 51 μM. KDM4C-IN-2 can be used for the research of cancer, such as prostate and breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
