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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
30 Results for "
KPC
" in MedChemExpress (MCE) Product Catalog:
Products (30)
30 Results for "KPC" in MCE Product Catalog:
Cat. No.: HY-W923278
CAS No.: 73547-70-3
Synonyms: GR20263 dihydrochloride
Target:
Research Areas:
Ceftazidime (GR20263) dihydrochloride is a cephalosporin β-lactam antibiotic. Ceftazidime dihydrochloride exhibits activity against susceptible Enterobacteriaceae, multidrug-resistant Gram-negative bacteria, Pseudomonas aeruginosa, and bacteria producing Ambler class A, C, and some class D β-lactamases, but shows no activity against microorganisms producing metallo-β-lactamases. Ceftazidime dihydrochloride reduces bacterial loads in mouse models of splenic, hepatic, and thigh infections, but has low efficacy against ESBL- and KPC-producing Enterobacteriaceae. Ceftazidime dihydrochloride can be used in research related to complicated urinary tract infections, complicated intra-abdominal infections, hospital-acquired pneumonia, carbapenemase-producing Klebsiella pneumoniae infections, carbapenem-resistant Enterobacterales infections, and severe Gram-negative bacterial infections .
Cat. No.: HY-109008R
CAS No.: 1452458-86-4
Synonyms: OP0595 free acid (Standard)
Research Areas:
Nacubactam (Standard) is the analytical standard of Nacubactam (HY-109008). This product is intended for research and analytical applications. Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and C β-lactamases. Nacubactam acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs. Nacubactam potentiates the antimicrobial activities of Piperacillin (HY-B1923), Cefepime (HY-B0692), and Meropenem (HY-13678) against CTX-M-15-positive Escherichia coli and KPC-positive Klebsiella pneumoniae .
Cat. No.: HY-P700392
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBAC1; UBA Domain Containing 1; UBADC1; GBDR1; KPC2; Ubiquitin-Associated Domain-Containing Protein 1; Kip1 Ubiquitination-Promoting Complex Protein 2; Glialblastoma Cell Differentiation-Related Protein 1; Kip1 Ubiquitination-Promoting Complex Subunit 2;
Species:
Human
Source:
E. coli
Cat. No.: HY-189234
Target:
Research Areas:
SAIT-PDZ-5179 is a small-molecule inhibitor of GIPC1 that directly binds to the PDZ domain of GIPC1 with a KD of 943 nM. SAIT-PDZ-5179 reduces the levels of GIPC1-associated signaling proteins and cell viability in pancreatic ductal adenocarcinoma models. SAIT-PDZ-5179 is used for studies on the GIPC1 signaling pathway and pancreatic ductal adenocarcinoma .
Cat. No.: HY-183786
Target:
Research Areas:
Anticancer agent 327, a fluorescent Andrographolide (HY-N0191) derivative, is an NF-κB p50 inhibitor. Anticancer agent 327 covalently binds to the p50 subunit of NF-κB. Anticancer agent 327 reduces levels of multiple oncogenic p53 proteins via the autophagy/lysosome pathway. Anticancer agent 327 can be used for the research of pancreatic ductal adenocarcinoma (Ex/Em = 488/515 nm)[1].
Cat. No.: HY-P11849
Research Areas:
Cat. No.: HY-186001
CAS No.: 2922732-38-3
Synonyms: RM-044
RMC-9945 (RM-044) is a selective, covalent, and orally active RAS (ON) G12D inhibitor. RMC-9945 enhances the transcriptional activity of β-Catenin/TCF. RMC-9945 induces cell state transition, forcing metastatic colorectal cancer cells to switch from the Emp1 + state to the Lgr5 + stem cell-like state. RMC-9945 achieves durable disease control in preclinical models of colorectal cancer with early liver metastasis, but shows reduced activity in late-stage metastasis models. RMC-9945 can be used in research related to metastatic colorectal cancer and pancreatic ductal adenocarcinoma .
Cat. No.: HY-111521R
CAS No.: 2031124-72-6
Synonyms: Carbavance (Standard)
Research Areas:
Meropenem-vaborbactam (Standard) is the analytical standard of Meropenem-vaborbactam (HY-111521). This product is intended for research and analytical applications. Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC50 of 0.5 μg/mL and an MIC90 of 8 μg/mL .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
