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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
LATS
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "LATS" in MCE Product Catalog:
Cat. No.: HY-N3999
CAS No.: 1609278-97-8
Synonyms: ESK246
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Cat. No.: HY-164401
CAS No.: 1802735-28-9
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QBS10072S is a LAT1-selective substrate with blood-brain barrier permeability that inhibits tumor growth. QBS10072S enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces interstrand DNA cross-linking and cell apoptosis, and reduces leptomeningeal dissemination. QBS10072S can be used in studies related to glioblastoma multiforme, diffuse intrinsic pontine glioma, triple-negative breast cancer brain metastases, and aggressive T-cell lymphoma .
Cat. No.: HY-120139A
CAS No.: 2994330-89-9
(R)-KMH-233 is the isomer of KMH-233 (HY-120139), and can be used as an experimental control. KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC50=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) .
Cat. No.: HY-108540R
CAS No.: 20448-79-7
Synonyms: 2-Amino-2-norbornanecarboxylic acid (Standard); LAT1-IN-1 (Standard)
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BCH (Standard) is the analytical standard of BCH. This product is intended for research and analytical applications. BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis .
Cat. No.: HY-P990610
Cat. No.: HY-147165A
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VT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-RS07538
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LATS1 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07539
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LATS2 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18181
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Lats2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23797
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Lats1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lats1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24655
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Lats2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07536
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LAT Human Pre-designed siRNA Set A contains three designed siRNAs for LAT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16816
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Lat Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lat gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07537
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LAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for LAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS21361
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Lat2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-129934S
Synonyms: Lat-NEt-d4
Cat. No.: HY-129934
CAS No.: 607351-44-0
Synonyms: Lat-NEt
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Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
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Cat. No.: HY-138489R
CAS No.: 1424635-83-5
Synonyms: LATS-IN-1 (Standard)
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TRULI (Standard) is the analytical standard of TRULI (HY-138489). This product is intended for research and analytical applications. TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 Kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues .
Cat. No.: HY-RS17343
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Lats1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lats1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
