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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
33 Results for "
PI4K
" in MedChemExpress (MCE) Product Catalog:
Products (33)
33 Results for "PI4K" in MCE Product Catalog:
Cat. No.: HY-L009
3,998 compounds
Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.
Kinase inhibitor library designed by MCE contains 3,998 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.
Cat. No.: HY-L009M
270 compounds
Kinases is a class of enzymes that adds chemicals called phosphates to other molecules, such as sugars or proteins. Protein phosphorylation serves as a critical regulatory mechanism for numerous cellular processes including cell division, metabolism, and signal transduction, with approximately 50% of cellular functions in humans being regulated by kinase activity. In drug discovery, kinases represent a major category of therapeutic targets, and kinase inhibitors constitute an important class of pharmaceuticals that block the activity of specific disease-associated enzymes, particularly in cancer and inflammatory disorders. Small molecule kinase inhibitors represent one of the fastest-growing drug categories, having received U.S. Food and Drug Administration (FDA) approval for both oncological and non-oncological indications. As of September 2023, over 70 FDA-approved small molecule kinase inhibitors are commercially available.
The MCE Kinase Inhibitor Library Mini contains 270 kinase inhibitors primarily targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.), and carbohydrate kinases. This collection includes 1-3 highly specific representative compounds per target, optimized for screening of kinase-related drug targets in pharmaceutical research.
Cat. No.: HY-106005R
CAS No.: 1314883-11-8
Target:
Research Areas:
MMV390048 (Standard) is the analytical standard of MMV390048 (HY-106005). This product is intended for research and analytical applications. MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent .
Cat. No.: HY-N19772
CAS No.: 137319-26-7
Category:
Target:
Cat. No.: HY-103583R
CAS No.: 1610610-48-4
Target:
Research Areas:
KDU731 (Standard) is the analytical standard of KDU731 (HY-103583). This product is intended for research and analytical applications. KDU731, an orally active C. parvum PI4K inhibitor with an IC50 value of 25 nM, blocks Cryptosporidium infection in vitro and in vivo . KDU731 is a promising agent candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety .
Cat. No.: HY-12016R
CAS No.: 587871-26-9
Target:
Research Areas:
KU-55933 (Standard) is the analytical standard of KU-55933 (HY-12016). This product is intended for research and analytical applications. KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 12.9 and 2.2 nM, respectively, and is highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.
Cat. No.: HY-RS27086
Target:
Research Areas:
Pi4k2a Rat Pre-designed siRNA Set A contains three designed siRNAs for Pi4k2a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20189
Target:
Research Areas:
Pi4k2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pi4k2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26693
Target:
Research Areas:
Pi4k2b Rat Pre-designed siRNA Set A contains three designed siRNAs for Pi4k2b gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-18746
CAS No.: 1513879-18-9
KAI-407 is an orally active inhibitor of Plasmodium PI4K kinase, which can broadly inhibit multiple stages of the parasite lifecycle. KAI-407 exhibits EC50s of for the blood stage of malignant Plasmodium of 81 nM; for the liver schizonts of P. yoelii of 88 nM; and IC50s for the liver schizonts and dormant bodies of P. cynomolgi of 0.64 μM and 0.69 μM respectively. KAI-407 can prevent Plasmodium berghei infection 100%. KAI-407 can be used for the study of vivax malaria .
Cat. No.: HY-P701742
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PI4KB; Phosphatidylinositol 4-Kinase, Wortmannin-Sensitive; Prev. PIK4CB; PI4KIIIBETA; PI4K-BETA; PI4K-Beta; PI4K92; PI4KBETA; Phosphatidylinositol 4-Kinase, Catalytic, Beta; PI4Kbeta; PtdIns 4-Kinase Beta; DFNA87; PI4KIII; PI4K92; NPIK; Phosphatidylinosi
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703335
Synonyms: PI4K2A; Phosphatidylinositol 4-Kinase Type 2-Alpha; Phosphatidylinositol 4-Kinase Type 2 Alpha; DKFZP761G1923; PI4KII; Phosphatidylinositol 4-Kinase Type II (PI4KII); PIK42A; NEDMSB; Phosphatidylinositol 4-Kinase Type II-Alpha
Species:
Human
Source:
E. coli
Cat. No.: HY-P703333
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PI4K2B; PI4KII-BETA; Phosphatidylinositol 4-Kinase Type 2 Beta; FLJ11105; PI4KIIB; Phosphatidylinositol 4-Kinase Type-II Beta; PIK42B; Phosphatidylinositol 4-Kinase Type II-Beta; Phosphatidylinositol 4-Kinase Type 2-Beta; Phosphatidylinositol 4-Kinase Typ
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
