Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
84 Results for "
single-stranded
" in MedChemExpress (MCE) Product Catalog:
Products (84)
84 Results for "single-stranded" in MCE Product Catalog:
Cat. No.: HY-110137R
CAS No.: 55368-40-6
Synonyms: DB75 dihydrochloride (Standard); NSC 305831 dihydrochloride (Standard)
Research Areas:
Furamidine (dihydrochloride) (Standard) is the analytical standard of Furamidine (dihydrochloride). This product is intended for research and analytical applications. Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine dihydrochloride is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 283 μM, and >400 μM, respectively). Furamidine dihydrochloride is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine dihydrochloride is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine dihydrochloride is also an antiparasite agent .
Cat. No.: HY-P11652
CAS No.: 857267-11-9
Target:
Research Areas:
Cat. No.: HY-P72074
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: AICDA; CDA2; Activation Induced Cytidine Deaminase; ARP2; AID; HEL-S-284; single-stranded DNA Cytosine Deaminase; Integrated Into Burkitt'S Lymphoma Cell Line Ramos; Activation-Induced Cytidine Deaminase; Epididymis Secretory Protein Li 284; Cytidine Amin
Species:
Mouse
Source:
E. coli
Cat. No.: HY-E70608
Target:
Research Areas:
PcrA spirase is an ATP-driven 3′ to 5′ helicase responsible for unwinding double-stranded DNA (dsDNA). PcrA spirase binds to dsDNA and unwinds it into two single-stranded DNAs (ssDNA).
Cat. No.: HY-P72080
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: APOBEC3A; A3A; Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3A; Probable DNA DC->DU-Editing Enzyme APOBEC-3A; PHRBN; single-stranded DNA Cytosine Deaminase; ARP3; APOBEC3A Transcript Variant 3; Apolipoprotein B MRNA Editing Enzyme, Catalytic Pol
Species:
Human
Source:
E. coli
Cat. No.: HY-148826A
Synonyms: ARC 183 sodium; BC 007 sodium
Target:
Research Areas:
Rovunaptabin sodium (ARC 183 sodium) is a DNA aptamer, which is a single-stranded DNA molecule consisting of 15 deoxynucleotides that forms well-defined three-dimensional configuration, allowing it to bind to thrombin with high affinity and specificity.
Cat. No.: HY-188056
CAS No.: 121714-70-3
Research Areas:
Biotin-11-UTP is a biotinylated uridine triphosphate that can be incorporated into short RNA strands via co-transcription with T7 RNA polymerase, and is used for synthesizing labeling reagents and detection markers. After binding to streptavidin, Biotin-11-UTP generates characteristic downward ionic current peaks during nanopore translocation, which allows the differentiation between modified and unmodified RNA. Biotin-11-UTP enables site-specific labeling of short RNA, and is suitable for single-molecule solid-state nanopore sensing detection. Biotin-11-UTP can serve as a raw material for synthesizing biotinylated single-stranded RNA probes, which is applied to rotavirus nucleic acid detection; it can also label single-stranded RNA probes targeting and immobilizing 28S ribosomal RNA in leukemia cells. Biotin-11-UTP can alter the electrophoretic mobility of transcribed RNA in agarose gels, and can be used to monitor the biotinylation degree of RNA probes .
Cat. No.: HY-P85588
Synonyms: Dmrpa1; Drosophila Replication Protein A; DRPA; DSSB; HSSB; Human single stranded DNA binding protein; MST075; MSTP075; p70; REPA 1; REPA1; Replication factor A; Replication factor A protein 1; Replication protein A 70 kDa DNA-binding subunit; Replication protein A 70kDa DNA binding subunit; Replication protein A1; 70kD; Replication protein A1; 70kD; Replication protein A1 70kDa; Replication protein A1; RF A; RF-A protein 1; RFA; RFA1_HUMAN; RP A; RP-A p70; RPA 1; RPA 70; RPA; RPA1; single stranded binding protein 70; single stranded DNA binding protein; single-stranded DNA-binding protein; Ssb70.
Cat. No.: HY-171171
CAS No.: 2649242-85-1
Target:
Research Areas:
NERx 329 is a replication protein A (RPA) inhibitor with an IC50 of 4.9 μM. NERx 329 blocks the interaction between RPA and single-stranded DNA, and induces functional RPA depletion, loss of single-stranded DNA gap protection, chromosome fragmentation and cell death. NERx 329 inhibits the DNA damage response signaling pathway, exhibits broad single-agent anticancer activity, and enhances the activity of DNA-damaging agents. NERx 329 can be used in research related to brca1-deficient breast cancer, non-small cell lung cancer, and brca1-deficient ovarian cancer .
Cat. No.: HY-P705531
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RPA1; single-stranded DNA-Binding Protein; Replication Protein A1; Replication Protein A1, 70kDa; REPA1; RF-A Protein 1; RPA70; RP-A P70; Replication Protein A 70 KDa DNA-Binding Subunit; Replication Protein A1 (70kD); Replication Factor A Protein 1; PFBM
Species:
Human
Source:
E. coli
Cat. No.: HY-E70900
Target:
Research Areas:
Topoisomerase II β, Human (EC 5.99.1.3) is a nuclear enzyme that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I, which makes single-stranded cuts in DNA, and type II enzymes, which cut and pass double-stranded DNA.
Cat. No.: HY-E70901
Target:
Research Areas:
Topoisomerase II α, Human (EC 5.99.1.3) is a nuclear enzyme that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I, which makes single-stranded cuts in DNA, and type II enzymes, which cut and pass double-stranded DNA.
Cat. No.: HY-E70902
Target:
Research Areas:
Topoisomerase II, Yeast (EC 5.99.1.3) is a nuclear enzyme that play essential roles in DNA replication, transcription, chromosome segregation, and recombination. All cells have two major forms of topoisomerases: type I, which makes single-stranded cuts in DNA, and type II enzymes, which cut and pass double-stranded DNA.
Cat. No.: HY-E70904
Target:
Research Areas:
Terminal Transferase, Calf (EC 2.7.7.31) is a template independent polymerase that catalyzes the addition of deoxynucleotides to the 3' hydroxyl terminus of DNA molecules. Protruding, recessed or blunt-ended double or single-stranded DNA molecules serve as a substrate for Terminal Transferase. Terminal Transferase does not have 5' or 3' exonuclease activity. The addition of Co 2+ in the reacton makes tailing more efficient.
Cat. No.: HY-D3082
CAS No.: 2222720-58-1
Target:
Research Areas:
Probe L is an AIE-based dual-sensing fluorescent probe for the detection of Zn 2+ and single-stranded DNA (ssDNA). Coordination of Probe L with Zn 2+ restricts intramolecular rotation and triggers ESIPT, turning on fluorescence at 490 nm. Upon further binding of the Probe L-Zn 2+ complex to ssDNA, enhanced emission is generated at 550 nm. Ex/Em = 365/490 nm (Zn 2+); Ex/Em = 365/550 nm (ssDNA) .
Cat. No.: HY-189061
Target:
Research Areas:
Topoisomerase IN-7 is a bacterial topoisomerase inhibitor, with an IC50 value of 47 nM against Staphylococcus aureus DNA gyrase, 85 nM against Escherichia coli DNA gyrase, and 1 nM against Escherichia coli topoisomerase IV. Topoisomerase IN-7 inhibits the supercoiling activity of DNA gyrase, suppresses the relaxation activity of topoisomerase IV, stabilizes single-stranded DNA cleavage complexes, inhibits biofilm formation of specific bacteria, stimulates biofilm formation of methicillin-resistant Staphylococcus aureus, and exhibits bactericidal activity. Topoisomerase IN-7 is selective for bacterial topoisomerases over human topoisomerase IIα, shows moderate cytotoxicity, and inhibits the hERG potassium channel. Topoisomerase IN-7 can be used in studies of bacterial infections .
Cat. No.: HY-100758R
CAS No.: 883003-62-1
Target:
Research Areas:
FUBP1-IN-1 (Standard) is the analytical standard of FUBP1-IN-1 (HY-100758). This product is intended for research and analytical applications. FUBP1-IN-1 is a potent FUSE binding protein 1 (FUBP1) inhibitor which interferes with the binding of FUBP1 to its single stranded target DNA FUSE sequence , with an IC50 value of 11.0 μM .
Cat. No.: HY-D3364
Research Areas:
RL480 is a green-emitting RNA fluorescent dye used for selective RNA labeling and imaging. RL480 contains an acylimidazole reactive group that undergoes selective acylation with the 2′-OH group of RNA ribose, and restricts intramolecular rotation through covalent binding to relieve the TICT quenching effect, thereby generating a fluorescence enhancement signal. RL480 enables selective fluorescent labeling of RNA over DNA, and is applicable to RNA gel detection, real-time RNA synthesis monitoring and live-cell RNA imaging. The detection wavelengths are Ex/Em = 480 nm/514 nm .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
