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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8555 Results for "
binding
" in MedChemExpress (MCE) Product Catalog:
Products (8555)
8555 Results for "binding" in MCE Product Catalog:
Cat. No.: HY-P75295
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DLL1; Delta-Like Ligand 1; Delta Like Canonical Notch Ligand 1; Delta-Like Protein; Drosophila Delta Homolog 1; DELTA1; Delta-Like Protein 1; NEDBAS; H-Delta-1; Delta1; Epididymis Secretory Sperm binding Protein; Delta; Delta (Drosophila)-Like 1; DL1; Del
Species:
Rat
Source:
HEK293
Cat. No.: HY-P75399
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD52; Cambridge Pathology 1 Antigen; Prev. CDW52; CDW52 Antigen (CAMPATH-1 Antigen); HE5; CD52 Antigen; CAMPATH-1 Antigen; CD52 Protein; EDDM5; HEL-S-171mP; Human Epididymis-Specific Protein 5; CDw52; CD52 Antigen (CAMPATH-1 Antigen); He5; Epididymal Secretory Protein E5; CD52 Molecule; Epididymis Secretory Sperm binding Protein Li 171mP
Species:
Human
Source:
HEK293
Cat. No.: HY-P75471
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BNIP3L; NIP3L; BCL2 Interacting Protein 3 Like; BCL2/Adenovirus E1B 19-Kd Protein-Interacting Protein 3a; BNIP3a; BCL2/Adenovirus E1B 19kDa Interacting Protein 3-Like; Nix; Adenovirus E1B19k-binding Protein B5; BCL2/Adenovirus E1B 19 KDa Protein-Interacti
Species:
Human
Source:
E. coli
Cat. No.: HY-P76690
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RAET1E; NKG2D Ligand 4; Retinoic Acid Early Transcript 1E; NKG2DL4; ULBP4; N2DL-4; LETAL; RAET1E Protein; BA350J20.7; RAET1E2; Lymphocyte Effector Toxicity Activation Ligand; N2DL4; RAE-1-Like Transcript 4; RL-4; UL16-binding Protein 4
Species:
Human
Source:
HEK293
Cat. No.: HY-P76691
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: RAET1E; NKG2D Ligand 4; Retinoic Acid Early Transcript 1E; NKG2DL4; ULBP4; N2DL-4; LETAL; RAET1E Protein; BA350J20.7; RAET1E2; Lymphocyte Effector Toxicity Activation Ligand; N2DL4; RAE-1-Like Transcript 4; RL-4; UL16-binding Protein 4
Species:
Human
Source:
HEK293
Cat. No.: HY-P81161
Synonyms: Apoptotic cysteine protease; Apoptotic protease Mch 5; C/EBP alpha; CAP4; Caspase 8 precursor; CCAAT Enhancer binding Protein alpha; CEBP; CEBP A; CEBP alpha; CEBPA; FADD homologous ICE/CED 3 like protease; FADD like ICE; FLICE; ICE like apoptotic protease 5; ICE8; MACH; MCH5; MORT1 associated CED 3 homolog; CEBP α, CEBP-α.
Cat. No.: HY-P702668
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CSNK1A1; CKIalpha; Casein Kinase 1 Alpha 1; Epididymis Secretory Sperm binding Protein Li 77p; CK1; Non-Specific Serine/Threonine Protein Kinase; Casein Kinase I Isoform Alpha; Down-Regulated In Lung Cancer; CK1a; Casein Kinase 1, Alpha 1; CKIa; HEL-S-77p
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P72970A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DLL1; Delta-Like Ligand 1; Delta Like Canonical Notch Ligand 1; Delta-Like Protein; Drosophila Delta Homolog 1; DELTA1; Delta-Like Protein 1; NEDBAS; H-Delta-1; Delta1; Epididymis Secretory Sperm binding Protein; Delta; Delta (Drosophila)-Like 1; DL1; Del
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P7890A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CFH; H Factor 1 (Complement); Prev. HF1; Adrenomedullin binding Protein; Prev. HF2; Beta-1-H-Globulin; Prev. HF; Factor H-Like 1; ARMS1; H Factor 1; ARMD4; Factor H; FHL1; AHUS1; HUS; AMBP1; Age-Related Maculopathy Susceptibility 1; CFHL3; H Factor 2 (Com
Species:
Human
Source:
HEK293
Cat. No.: HY-P705141
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DLL1; Delta-Like Ligand 1; Delta Like Canonical Notch Ligand 1; Delta-Like Protein; Drosophila Delta Homolog 1; DELTA1; Delta-Like Protein 1; NEDBAS; H-Delta-1; Delta1; Epididymis Secretory Sperm binding Protein; Delta; Delta (Drosophila)-Like 1; DL1; Del
Species:
Human
Source:
HEK293
Cat. No.: HY-P705504
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DLL1; Delta-Like Ligand 1; Delta Like Canonical Notch Ligand 1; Delta-Like Protein; Drosophila Delta Homolog 1; DELTA1; Delta-Like Protein 1; NEDBAS; H-Delta-1; Delta1; Epididymis Secretory Sperm binding Protein; Delta; Delta (Drosophila)-Like 1; DL1; Del
Species:
Human
Source:
HEK293
Cat. No.: HY-P705629
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CUL2; CUL-2; Cullin 2; Testis Secretory Sperm-binding Protein Li 238E; Cullin-2; RBX1; E3 Ubiquitin-Protein Ligase RBX1; Ring-Box 1; RING Finger Protein 75; RNF75; RING-Box Protein 1; ROC1; Ring-Box 1, E3 Ubiquitin Protein Ligase; Regulator Of Cullins 1;
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P86737A
Synonyms: STAT3(phospho Y705); p-STAT3(phospho Y705); phospho-Stat3(pTyr705); STAT3(phospho-Tyr705); p-STAT3(Tyr705); phosphorylated Stat3(pTyr705); p-Stat3; Acute Phase Response Factor; APRF; DNA binding protein APRF; FLJ20882; MGC16063; Signal Transductor and Activator of Transcription 3; STAT 3; STAT3_HUMAN.
Cat. No.: HY-P810987
Synonyms: EDJ, ERJ3, HDJ9, PSEC0121, UNQ537/PRO1080, DNAJB11, DnaJ homolog subfamily B member 11, APOBEC1-binding protein 2, DnaJ protein homolog 9, ER-associated DNAJ, ER-associated Hsp40 co-chaperone, Endoplasmic reticulum DNA J domain-containing protein 3, HEDJ, Human DnaJ protein 9, PWP1-interacting protein 4, ABBP-2, ER-resident protein ERdj3, ERdj3, ERj3p, hDj-9
Cat. No.: HY-118156
CAS No.: 155238-60-1
L-699333 is a 5-lipoxygenase (5-LO) inhibitor belonging to the thieno[2,3,4-cd]indole class. This compound has a 2-ethoxybutyric acid side chain and is a potent inhibitor of the biosynthesis of 5-HPETE and LTB4 produced from human 5-LO, with ICm values of 22 nM, 7 nM, and 3.8 pM for human neutrophils and whole blood, respectively. L-699333 has shown anti-inflammatory and antiasthmatic effects in a variety of animal models, including rat pleurisy models, antigen-induced wheezing models, and awake macaque and sheep asthma models. Its inhibition of 5-LO is highly selective, with higher ICm values or stronger competitive inhibition in FLAP binding assays compared to inhibition of human 15-LO, porcine 12-LO, and ram epididymal cyclooxygenase. The racemic enantiomer 14g of L-699333 is the most potent enantiomer to date, with inhibitory effects similar to those of the known MK-0591, which has been shown in clinical trials to inhibit the biochemical effects of LTB4 biosynthesis in vitro and LTE4 excretion in urine.
Cat. No.: HY-137055
CAS No.: 1171824-96-6
PF-3774076 is a highly central nervous system (CNS) penetrant, potent, and selective human α1A-adrenoceptor partial agonist. It exhibits good potency and selectivity in multiple binding and functional assays. PF-3774076 increases peak urethral pressure in anesthetized female dogs in a dose-dependent manner via a central mechanism. PF-3774076 affects both the proximal and distal portions of the urethra in vivo. These properties suggest that PF-3774076 may have significant benefit in the treatment of stress urinary incontinence (SUI) as a CNS-penetrant α1A receptor partial agonist. However, despite its partial agonism and selectivity for α1A receptors, PF-3774076 failed to provide adequate safety differences in in vivo models of cardiovascular function. This may be due to the simultaneous activation of both peripheral and central α1A receptors. These data suggest that while central α1A partial agonists may have significant benefit in the treatment of SUI, this class of agents may have difficulty achieving the desired urethral selectivity without affecting cardiovascular function.
Cat. No.: HY-141878A
CAS No.: 2767983-77-5
Target:
Research Areas:
di-Ellipticine-RIBOTAC TFA is a RNase recruiting chimera (RIBOTAC) degrader, capable of specifically binding and degrading expanded G4C2 RNA repeat (r(G4C2) exp). di-Ellipticine-RIBOTAC TFA selectively binds the three-dimensional (3D) structure formed by r(G4C2) exp and that recruits an endogenous ribonuclease (RNase) to cleave r(G4C2) exp. di-Ellipticine-RIBOTAC TFA selectively degrades the mutant chromosome 9 open reading frame 72 (C9orf72) allele and reduces quantities of toxic dipeptide repeat proteins (DPRs) translated from r(G4C2) exp. di-Ellipticine-RIBOTAC TFA significantly improves the pathological phenotype of amyotrophic lateral sclerosis/ frontotemporal dementia (c9ALS/FTD) in cells and mouse models. di-Ellipticine-RIBOTAC TFA can be used for the study of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) .
Cat. No.: HY-162275
CAS No.: 861224-48-8
Research Areas:
JMJD1C-IN-1 is an orally active and selective inhibitor of JMJD1C (IC50 = 0.59 μM, Kd = 1.96 μM). JMJD1C-IN-1 inhibits the binding of JMJD1C to H3K9me2 peptide substrate in the HTRF assay (IC50 = 1.47 μM). JMJD1C-IN-1 disrupts intratumoral regulatory T (Treg) cell fitness by dual mechanisms: promoting H3K9me2 accumulation to downregulate PD1 expression and reducing STAT3 demethylation to enhance STAT3 activation. JMJD1C-IN-1 demonstrates dose-dependent antitumor efficacy in multiple mouse tumor models (MCA205 fibrosarcoma, B16-F10 melanoma, LLC lung cancer, Hepa1-6 hepatocellular carcinoma, CT26 colorectal cancer). JMJD1C-IN-1 can be used for the study of tumor immunotherapy by selectively targeting intratumoral Treg cells .
Cat. No.: HY-179560
Research Areas:
PMV6-PEG4-BI2536 is an RIPTAC-like bifunctional molecule that promotes the formation of the p53 Y220C-PLK1 ternary complex (EC50 = 1.4 μM). PMV6-PEG4-BI2536 causes PLK1 mislocalization and inhibits PLK1 activity, inducing G2/M phase arrest and apoptosis in p53 Y220C-mutant cells, while sparing cells with wild-type TP53. PMV6-PEG4-BI2536 can be used in research on uterine, gastric, pancreatic, prostate, and breast cancers harboring the p53 Y220C mutation. PMV6-PEG4-BI2536 is composed of PMV6 (a p53 Y220C mutant-binding ligand), PEG4 (a linker), and BI2536 (HY-159493) (a PLK inhibitor) .
Cat. No.: HY-182361
CAS No.: 3097515-05-1
NUAK1-IN-3 is a potent and selective NUAK1 inhibitor with an IC50 of 0.49 nM. NUAK1-IN-3 also inhibits NUAK2 and JAK3 with IC50 values of 265 and 225 nM. NUAK1-IN-3 engages Glu139 of NUAK1, forms a salt bridge between its bicyclic ring nitrogen and Asp142, and uses a fluorine atom to enhance hydrophobic binding interactions. NUAK1-IN-3 attenuates MYPT1 phosphorylation, suppresses the NUAK1-MYPT1 signaling axis, and inhibits proliferation, migration, and invasion of triple-negative breast cancer cells. NUAK1-IN-3 reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) marker alterations, downregulates Snail and N-cadherin, and upregulates E-cadherin in tumor tissues. NUAK1-IN-3 suppresses tumor growth in triple-negative breast cancer xenograft models. NUAK1-IN-3 can be used for the research of triple-negative breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
