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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
123 Results for "
Integrase
" in MedChemExpress (MCE) Product Catalog:
Products (123)
123 Results for "Integrase" in MCE Product Catalog:
Cat. No.: HY-123066A
CAS No.: 1263143-51-6
Target:
Research Areas:
(E)-DIDS monohydrate sodium is the E-isomer of DIDS monohydrate sodium (HY-123066). DIDS is a hRAD51 inhibitor with an IC50 value of 90 μM. DIDS exhibits significant inhibitory activity against HIV-1 integrase with an IC50 value of 5 μM .
Cat. No.: HY-10522R
CAS No.: 957890-42-5
Synonyms: CX05168 (Standard); CX04328 (Standard)
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Research Areas:
LEDGIN6 (Standard) is the analytical standard of LEDGIN6 (HY-10522). This product is intended for research and analytical applications. LEDGIN6 (CX05168) is a quinoline-based protein-protein interaction inhibitor of LEDGF/p75 and HIV integrase .
Cat. No.: HY-N16888
CAS No.: 450407-31-5
Target:
Cat. No.: HY-100083R
CAS No.: 1335210-23-5
Target:
Research Areas:
Dolutegravir intermediate-1 (Standard) is the analytical standard of Dolutegravir intermediate-1 (HY-100083). This product is intended for research and analytical applications. Dolutegravir intermediate-1 is a synthetic intermediate of Dolutegravir extracted from patent WO 2016125192 A2. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-1 infection.
Cat. No.: HY-14740R
CAS No.: 697761-98-1
Synonyms: GS-9137 (Standard); JTK-303 (Standard); D06677 (Standard)
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Research Areas:
Elvitegravir (Standard) is the analytical standard of Elvitegravir. This product is intended for research and analytical applications. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
Cat. No.: HY-14740S2
Synonyms: GS-9137-13C6 ; JTK-303-13C6 ; D06677-13C6
Cat. No.: HY-150080
CAS No.: 1803444-21-4
Synonyms: BMS-986180
Target:
Research Areas:
GSK3739936 (BMS-986180) is a potent HIV-1 allosteric integrase inhibitor with an IC50 value of 11.1 nM and an EC50 value of 1.7 nM. GSK3739936 is also a weak CYP inhibitor (IC50>24.3 μM). GSK3739936 shows favorable pharmacokinetic property in preclinical species with rapid absorption, low to moderate clearance and excellent oral bioavailability .
Cat. No.: HY-N11288
CAS No.: 1015171-69-3
Target:
Cat. No.: HY-14740S1
Synonyms: GS-9137-d6; JTK-303-d6; D06677-d6
Cat. No.: HY-14740S3
CAS No.: 1131640-69-1
Synonyms: GS-9137-d5; JTK-303-d5; D06677-d5
Cat. No.: HY-N16050
CAS No.: 1015171-68-2
Synonyms: Ethyl salvionolate A
Cat. No.: HY-P85958
Synonyms: BAF47, INI1, SNF5L1, SMARCB1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, BRG1-associated factor 47, Integrase interactor 1 protein, SNF5 homolog, hSNF5
Cat. No.: HY-N6711
CAS No.: 57749-43-6
Cat. No.: HY-15592R
CAS No.: 1051375-10-0
Synonyms: GSK-1265744 (Standard); S/GSK1265744 (Standard)
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Research Areas:
Cabotegravir (Standard) is the analytical standard of Cabotegravir. This product is intended for research and analytical applications. Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC50 values of 2.5 nM, 0.41 μM and 0.81 μM for HIVADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .
Cat. No.: HY-15592S4
Synonyms: GSK-1265744-d6; S/GSK1265744-d6
Cat. No.: HY-183157
CAS No.: 2366269-07-8
HIV-1-IN-93 is a HIV-1 RNase H inhibitor with an IC50 of 6.09 μM. HIV-1-IN-93 shows low cytotoxicity and can be used in studies related to HIV-1 infection .
Cat. No.: HY-185449
CAS No.: 1909302-89-1
Research Areas:
HIV RT-IN-2 is a HIV reverse transcriptase inhibitor with an IC50 value of 1.2 μM for HIV-1 RT RNA-dependent DNA polymerase. HIV RT-IN-2 potently inhibits all three modes of HIV-1 RT-associated RNase H activity (internal, 3'-DNA directed, 5'-RNA directed cleavage) and inhibits HIV-1 replication. HIV RT-IN-2 can be used for the research of HIV-1 infection .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
