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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
β-sheet
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "β-sheet" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P3343A
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1
1 Cited Publications
Cat. No.: HY-P3343
CAS No.: 142154-55-0
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Cat. No.: HY-19621
CAS No.: 62054-67-5
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THS-044 is a modulator of the formation of the HIF2α/ARNT heterodimer. THS-044 binding stabilizes the HIF2α PAS-B folded state (KD = 2 μM), for regulating HIF2 activity in endogenous and pathological settings, and does not bind to HIF1α or ARNT PAS-B. THS-044 can be used for the study of diseases related to hypoxia .
Cat. No.: HY-P10294
CAS No.: 593266-60-5
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Cat. No.: HY-P1047
CAS No.: 182912-74-9
Synonyms: [Pro18, Asp21] β-Amyloid (17-21)
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Cat. No.: HY-P99899
CAS No.: 2052591-32-7
Synonyms: PR-1498487
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Cat. No.: HY-137557
CAS No.: 1565797-16-1
Synonyms: APN1607; PM-PBB3
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Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used for the detection of Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-sheet of paired helical filaments (PHFs) and straight filaments (SFs) of tau protein, as well as in the C-shaped cavity of SFs. In addition, APN-1607 binds to intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART) and posterior cortical atrophy (PCA). Florzolotau shows promise for PET imaging studies of neurological disorders, particularly tau proteinopathies .
Cat. No.: HY-P3688A
Synonyms: Aβ (1-38) TFA; Aβ38 TFA
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Cat. No.: HY-P2632
CAS No.: 289042-25-7
Synonyms: RADA16
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Cat. No.: HY-N8671
CAS No.: 256520-90-8
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Cat. No.: HY-P5905
Synonyms: Citrullinated Aβ (1-42); Citrullinated Aβ42
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Synonyms: 3-Phenylpropiophenone; β-Phenylpropiophenone
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Dihydrochalcone (3-Phenylpropiophenone) is a Aβ aggregation inhibitor. Dihydrochalcone destabilizes Aβ17-42 protofibrils by disrupting the β-sheet of β1 region. Dihydrochalcone destabilizes both U-shaped Aβ40/Aβ42 protofibrils and S-shaped Aβ42 protofibrils by binding to the protofibril cavity. Dihydrochalcone is the main component of daemonorops draco tree .
Cat. No.: HY-P10578
CAS No.: 906357-94-6
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Cat. No.: HY-W835959
CAS No.: 2361566-66-5
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ACI-3024 is an an orally active and highly selective Tau protein aggregation inhibitor. ACI-3024 decrease the β-sheet content and seeding properties of pathological Tau from different Tauopathies, leading to a significant rescue of the Tau-induced neurodegeneration and neuroinflammation in a cellular model. ACI-3024 is promising for research of neurodegenerative diseases .
Cat. No.: HY-P5917A
Synonyms: Vaejovis mexicanus peptide 24 TFA
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Cat. No.: HY-P4882
CAS No.: 183449-57-2
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Cat. No.: HY-P6299
CAS No.: 944792-75-0
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Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
