289042-25-7
Chemical Structure
RAD16-I
Synonym(s): RADA16
- CAS No.: 289042-25-7
- Formula:C66H113N29O25
- Molecular Weight:1712.78
InChIKey: MXRLSGRWOVUTRA-UNPFZTJUSA-N
SMILES: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Biological Activity: RAD16-I (RADA16) is a non-directed self-assembling peptide hydrogel. Under physiological conditions, RAD16-I spontaneously forms a three-dimensional nanofiber network that mimics the extracellular matrix, and possesses excellent properties such as high water content, biocompatibility and degradability. RAD16-I serves as an ideal scaffold for three-dimensional cell culture. RAD16-I not only maintains cell viability and induces self-organization, but also supports cell adhesion, proliferation, differentiation and insulin secretion, effectively stabilizes islet clusters and promotes directed differentiation of the cardiac lineage. RAD16-I can construct a cell-friendly nano-microenvironment for research related to diseases such as myocardial infarction and diabetes[1][2][3].
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RAD16-I | RAD16-I (RADA16) is a non-directed self-assembling peptide hydrogel. Under physiological conditions, RAD16-I spontaneously forms a three-dimensional nanofiber network that mimics the extracellular matrix, and possesses excellent properties such as high water content, biocompatibility and degradability. RAD16-I serves as an ideal scaffold for three-dimensional cell culture. RAD16-I not only maintains cell viability and induces self-organization, but also supports cell adhesion, proliferation, differentiation and insulin secretion, effectively stabilizes islet clusters and promotes directed differentiation of the cardiac lineage. RAD16-I can construct a cell-friendly nano-microenvironment for research related to diseases such as myocardial infarction and diabetes. | |||||||||||||||||||||
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- [1]. Castells-Sala C, et al. Three-Dimensional Cultures of Human Subcutaneous Adipose Tissue-Derived Progenitor Cells Based on RAD16-I Self-Assembling Peptide. Tissue Eng Part C Methods. 2016;22(2):113-124. [Content Brief]
- [2]. Sanchez B, et al. Towards on line monitoring the evolution of the myocardium infarction scar with an implantable electrical impedance spectrum monitoring system. Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:3223-3226. [Content Brief]
- [3]. Aloy-Reverté C, et al. Use of RGD-Functionalized Sandwich Cultures to Promote Redifferentiation of Human Pancreatic Beta Cells After In Vitro Expansion. Tissue Eng Part A. 2018;24(5-6):394-406. [Content Brief]
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