β-Lactoglobulin
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β-Lactoglobulin, a major whey protein, is a small globular protein from the lipocalin family. β-Lactoglobulin is an important source of the essential and branched-chain amino acids (leucine, isoleucine, and valine). β-Lactoglobulin shows antioxidant properties, because it contains two disulfide bonds and one free thiol group. β-Lactoglobulin is a ligand transport agent. β-Lactoglobulin is one of the major allergens in milk and can be utilized in the research for developing safe hypoallergenic dairy products.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 9045-23-2
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Lipocalin Family Isoforms
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Biological Activity
Heat treatment of bovine milk antigen bovine β-Lactoglobulin generates ligands for RAGE, Gal-3, CD-36 and SR-AI as a result of structural changes and glycation. Glycated BLG is less sensitive to digestion and maintains its binding to RAGE and Gal-3. Post-digestion retained immunogenicity of glycated BLG may be mediated via RAGE as a signaling pathway, and via Gal-3 facilitating internalization[1].
β-Lactoglobulin possesses antioxidant properties, because it contains two disulfide bonds (Cys-66 to Cys-160, Cys-106 to Cys-119) and one free thiol group (Cys-121)[2].
Structurally, β-Lactoglobulin has unique features, i.e. a rigid β-barrel core surrounded by one long and several short α-helices with two disulfide (SS) bonds and one free cysteinyl thiol (SH) buried in the core. There are two variants of β-Lactoglobulin (BLG). Variant A (BLGA) has Asp64 and Val118 in place of Gly64 and Ala118 of another variant, B (BLGB). These variants are in equilibrium with a hetero- or homo-dimer under physiological conditions[3].
β-Lactoglobulin is the building block of amyloid fibrils and has a variety of applications, including stabilizing gels or emulsions[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9045-23-2
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Appearance Solid
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Color White to off-white
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SMILES
[b-Lactoglobulin]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
H2O : ≥ 5 mg/mL
* "≥" means soluble, but saturation unknown.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Teodorowicz M, et al. Enhanced Uptake of Processed Bovine β-Lactoglobulin by Antigen Presenting Cells: Identification of Receptors and Implications for Allergenicity. Mol Nutr Food Res. 2021;65(8):e2000834. [Content Brief]
[2]. Gołębiowski A, et al. Isolation and Self-Association Studies of Beta-Lactoglobulin. Int J Mol Sci. 2020;21(24):9711. Published 2020 Dec 19. [Content Brief]
[3]. Iwaoka M, et al. Oxidative folding pathways of bovine milk β-lactoglobulin with odd cysteine residues. FEBS Open Bio. 2019;9(8):1379-1391. [Content Brief]
[4]. Uttinger MJ, et al. Measurement of length distribution of beta-lactoglobulin fibrils by multiwavelength analytical ultracentrifugation. Eur Biophys J. 2020;49(8):745-760. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Lactoglobulin Related Classifications
Cat. No.: HY-NP008
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- β-Lactoglobulin
- 9045-23-2
- Lipocalin Family
- secretion
- signal sequence
- hydrophobic hole
- betaI-strand
- N- and C-terminal regions
- CD
- recombinant
- SDS/PAGE
- pico- to nanosecond time scale
- indirect Fourier transformation
- betaF
- Saccharomyces cerevisiae
- protein
- bovine beta-lactoglobulin A
- native PAGE
- \u03b2-lactoglobulin
- fluorescence spectroscopy
- glycation of β-lactoglobulin
- small-angle neutron scattering
- N-terminal sequencing
- Beta-lactoglobulin
- pH
- β-sheet protein
- disulphide bonds
- aggregation of β-lactoglobulin
- aggregation
- betaH strands
- oligomeric forms
- beta-lactoglobulin
- N-terminal methionine
- folding of β-lactoglobulin
- disulfide bond rearrangement
- non-native helix formation
- eight-stranded continuous antiparallel beta-barrel
- betaG
- loops
- NaCl concentration
- digestion of β-lactoglobulin
- monomeric native state
- Ligand binding
- denaturation
- yeast
- dynamics
- kinetic model
- major alpha-helix
- loop EF
- scattered light intensity
- association
- β-lactoglobulin (β-LG)
- Kluyveromyces lactis
- expression
- X-ray dimeric structure
- protein polymer particles
- Protein stability
- solution structure
- Inhibitor
- inhibitor
- inhibit