Search Result

Results for "

MCP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (5) AMPK (1) ANGPTL (1) Antibiotic (2) Apoptosis (3) Arginase (2) Bacterial (6) Bcl-2 Family (1) BMX Kinase (1) Btk (1) Cannabinoid Receptor (1) CaSR (1) CCR (6) COX (2) Discoidin Domain Receptor (1) Drug Intermediate (2) Endogenous Metabolite (3) Epigenetic Reader Domain (6) ERK (2) FABP (1) Fluorescent Dye (1) Fungal (2) GSK-3 (1) HIF/HIF Prolyl-Hydroxylase (2) HIV (1) Hydroxycarboxylic Acid Receptor (HCAR) (1) IFNAR (1) IMPDH (1) Integrin (1) Interleukin Related (27) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Leukotriene Receptor (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) MDM-2/p53 (1) MMP (3) mRNA (1) NF-κB (15) NO Synthase (9) NOD-like Receptor (NLR) (3) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (2) Parasite (4) PI3K (3) PPAR (4) Prostaglandin Receptor (1) Protease Activated Receptor (PAR) (3) Pyruvate Kinase (2) Raf (1) Ras (1) Reactive Oxygen Species (ROS) (2) Reference Standards (8) SARS-CoV (1) Sirtuin (1) Small Interfering RNA (siRNA) (4) Src (1) STAT (3) Survivin (1) TGF-beta/Smad (3) Thrombin (2) TNF Receptor (18) Transmembrane Glycoprotein (1) TRP Channel (1) VEGFR (3) Virus Protease (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (10) Endocrinology (1) Infection (11) Inflammation/Immunology (56) Metabolic Disease (20) Neurological Disease (7)
Oligonucleotides:	Aptamers (1) Chemokine & Receptors (1) Rat Pre-designed siRNA Sets (1) mRNA (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125864

Fibrinogen (Bovine) 2 Publications Verification	Interleukin Related NF-κB	Inflammation/Immunology
Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines *MCP-1* and *MCP-1*. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

HY-13324

Bardoxolone methyl Maximum Cited Publications 41 Publications Verification RTA 402; NSC 713200; CDDO Methyl ester	Keap1-Nrf2 SARS-CoV Virus Protease	Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Bardoxolone (CDDO; RTA 401) methyl is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC₅₀ value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) .

HY-B0498

Bindarit Maximum Cited Publications 29 Publications Verification AF2838	CCR	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8*, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity .

HY-147429

Zosurabalpin Abx MCP; RG6006	Antibiotic Bacterial	Infection
Zosurabalpin is a polypeptide antibiotic targeting LPS transporter (LptB₂FGC complex), which can block the transport of LPS and lead to endotoxin accumulation in cells, and has shown excellent antibacterial activity against Carbapenem-resistant Acinetobacter baumanni (CRAB) .

HY-33037

Phenazine-1-carboxylic acid	Fungal	Infection Inflammation/Immunology Cancer
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation .

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and *MCP1. Astegolimab mitigates IL33-increased p-p65/p65* ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

HY-N3007

Naringenin chalcone 5+ Cited Publications	Drug Intermediate Apoptosis NO Synthase	Inflammation/Immunology Cancer
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of *MCP-1* and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties .

HY-112868B

ABH hydrochloride 1 Publications Verification	Arginase NO Synthase Integrin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
ABH (hydrochloride) is an orally active arginase inhibitor (K_i = 8.5 nM). ABH hydrochloride promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, VCAM-1, *MCP-1*). ABH hydrochloride improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis .

HY-N9914

D-Psicose D-Allulose	p38 MAPK NF-κB	Metabolic Disease
D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease .

HY-N0847

Micheliolide 5+ Cited Publications	NF-κB PI3K Akt TGF-beta/Smad	Inflammation/Immunology Cancer
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-N2572

Eupafolin Nepetin; 6-Methoxyluteolin	Interleukin Related	Neurological Disease Inflammation/Immunology Cancer
Eupafolin (Nepetin) (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Eupafolin inhibits IL-6, IL-8 and *MCP-1* secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells .

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, VCAM-1, *MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces p-AMPK* and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis .

HY-12642

Diethylcarbamazine citrate 1 Publications Verification	Parasite Bacterial TNF Receptor Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Diethylcarbamazine citrate is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine citrate reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine citrate reduces serum levels of leptin, TNF-α, IL-6, *MCP-1*, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine citrate enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine citrate can be used for the researches of bronchial asthma, insulin resistance and infection .

HY-114164G

Murine Thrombin 5+ Cited Publications	Thrombin Protease Activated Receptor (PAR) MMP VEGFR Epigenetic Reader Domain	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Murine Thrombin is a murine serine protease that plays a central role in blood coagulation. Murine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Murine Thrombin activates PAR1, induces the production of *MCP-1, MMP3* and VEGF in mouse intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Murine Thrombin activity increases significantly in paraoxon-induced status epilepticus .

HY-P990297

*Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)* 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human *CCL2/MCP-1* IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV .

HY-108323

CCR2 antagonist 4 5+ Cited Publications Teijin compound 1	CCR	Inflammation/Immunology
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC₅₀s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC₅₀ of 24 nM .

HY-103362

CCR2 antagonist 4 hydrochloride 5+ Cited Publications Teijin compound 1 hydrochloride	CCR	Inflammation/Immunology
CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC₅₀s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC₅₀ of 24 nM .

HY-103325

JTE-907	Cannabinoid Receptor TRP Channel Interleukin Related ANGPTL VEGFR	Metabolic Disease Inflammation/Immunology
JTE-907 is a selective and orally active cannabinoid CB2 receptor inverse agonist and exerts anti-inflammatory effects. JTE-907 upregulates IL-6, *MCP-1, IL-1β, VEGF, ANGPTL4, and TRPV1* in mature adipocytes. JTE-907 downregulates CB1, *MCP-1, and IL-1β* in preadipocytes. JTE-907 inhibits ear swelling in mice. JTE-907 reverses the protective effects of CB2 agonists and Anandamide (HY-10863) against cytokine-evoked colonic mucosal damage. JTE-907 can be used for the research of allergic dermatitis, obesity, and colitis .

HY-110217

BMS-566419	IMPDH	Inflammation/Immunology
BMS-566419 is an orally active IMPDH inhibitor with an IC₅₀ of 91 nM against human IMPDH I and 68 nM against human IMPDH II. BMS-566419 exerts anti-heart transplant rejection and anti-renal fibrosis effects, and inhibits the expression of *MCP-1, TGF-β1* as well as antibody production. BMS-566419 can be used in research on renal fibrosis and organ transplantation .

HY-125740

Malvidin-3-glucoside chloride Malvidin-3-O-glucoside chloride; Oenin chloride	NF-κB TNF Receptor NO Synthase Interleukin Related	Inflammation/Immunology
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as *MCP-1, ICAM-1, and IL-6*, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36	CCR	Inflammation/Immunology Cancer
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice .

HY-123673

MCP110 2 Publications Verification	Ras Raf	Cancer
MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors .

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced *IL‑6/MCP‑1* and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

HY-P5523A

iE-DAP dihydrochloride	NOD-like Receptor (NLR) NF-κB Interleukin Related	Metabolic Disease
iE-DAP dihydrochloride is a Nod1 agonist. iE-DAP dihydrochloride activates NOD1, which in turn activates the NF-κB signaling pathway and MLCK signaling pathway, inducing cellular inflammatory responses and tight junction disruption. iE-DAP dihydrochloride downregulates the expression of ZO-1 and Occludin genes. iE-DAP dihydrochloride increases the secretion of IL-6, GRO-α, *MCP-1, IL-8* and MIP-1β in term human trophoblast cell cultures. iE-DAP dihydrochloride triggers preterm birth in pregnant mice, reduces fetal body weight, and induces fetal inflammation. iE-DAP dihydrochloride can be used in studies related to mastitis and preterm birth .

HY-139481

TL-895 1 Publications Verification	Btk BMX Kinase Interleukin Related TNF Receptor	Neurological Disease Inflammation/Immunology Cancer
TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor. TL-895 is active against recombinant BTK (average IC₅₀: 1.5 nM) and inhibits only three additional kinases BLK, BMX (IC₅₀ = 1.6 nM) and TXK with IC₅₀ within tenfold of BTK activity. TL-895 inhibits BTK auto-phosphorylation at the Y223 phosphorylation site (IC₅₀: 1-10 nM). The TL-895 effectively inhibits the production of inflammatory factors such as IL-8, IL-1β, *MCP-1* and TNF-α by monocytes or macrophages, and reduces the chemotactic migration of MF cells towards SDF-1. TL-895 is used be for studies of chronic lymphocytic leukemia (CLL), myelofibrosis (MF), and B-cell malignancies .

HY-N1940

β-Anhydroicaritin 3 Publications Verification Cycloicaritin	Interleukin Related TNF Receptor MMP	Inflammation/Immunology Cancer
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-12642A

Diethylcarbamazine 1 Publications Verification	Parasite Bacterial TNF Receptor Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
Diethylcarbamazine is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine reduces serum levels of leptin, TNF-α, IL-6, *MCP-1*, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine can be used for the researches of bronchial asthma, insulin resistance and infection .

HY-138623

GSK789	Epigenetic Reader Domain TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
GSK789 is a selective inhibitor of BET BD1. GSK789 inhibits the growth of leukemia cell lines. GSK789 inhibits LPS-stimulated production of *MCP-1, TNFα* and IL-6 in human whole blood. GSK789 exhibits antiproliferative, anti-inflammatory and immunomodulatory activities. GSK789 can be used in research related to cancers such as leukemia, as well as inflammatory and immune diseases .

HY-156025

HCAR2 agonist 1	Hydroxycarboxylic Acid Receptor (HCAR)	Inflammation/Immunology
HCAR2 agonist 1 (Compound 9n) is a G_i protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the G_i protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis .

HY-N9914R

D-Psicose (Standard) D-Allulose (Standard)	Reference Standards p38 MAPK NF-κB	Metabolic Disease
D-Psicose (Standard) is the analytical standard of D-Psicose (HY-N9914). This product is intended for research and analytical applications. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease .

HY-125726

Sulfo galactosylceramide (3'-sulfo)Galβ-Cer(d18:1/24:1); N-Nervonoyl Sulfatide; C24:1 Sulfatide	Nuclear Factor of activated T Cells (NFAT)	Inflammation/Immunology
Sulfo galactosylceramide (N-Nervonoyl Sulfatide; C24:1 Sulfatide) is a glycolipid and the major sulfolipid species in mature myelin. Sulfo galactosylceramide interacts with C-type lectins and immunoglobulin-like receptors, with the highest affinity for LMIR5. Sulfo galactosylceramide induces MCP-1 production by basophils but not mast cells, and increases NFAT activation via LMIR5. Sulfo galactosylceramide alleviates symptoms and improves survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE), and reduces inflammatory lesions and the number of infiltrating mononuclear cells in the lumbar spinal cord of EAE mice.

HY-158990

GE1111	Mas-related G-protein-coupled Receptor (MRGPR) Interleukin Related TNF Receptor Akt ERK	Inflammation/Immunology
GE1111 is a MRGPRX2 antagonist (IC₅₀ = 9.4 μM). GE1111 inhibits MRGPRX2/MRGPRB2-mediated mast cell activation. GE1111 reduces the expressions of TSLP, IL-13, *MCP-1, TNF-α, IL-1β* and periostin, maintains the expression levels of claudin 1 and involucrin, restores the phagocytic activity of macrophages, and attenuates the activation of STIM1 and phosphorylated AKT. GE1111 exerts anti-inflammatory and anti-allergic effects in multiple animal models. GE1111 is applicable to the research related to rosacea, atopic dermatitis and ulcerative colitis .

HY-N7064

Iminostilbene	Pyruvate Kinase COX STAT TNF Receptor NO Synthase Interleukin Related HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease Inflammation/Immunology
Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and *MCP-1*, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases .

HY-164082

Methyl clofenapate Clofenapate methyl ester; MCP	PPAR	Metabolic Disease Cancer
Methyl clofenapate (Clofenapate methyl ester; MCP) is a peroxisome proliferator, which can induce hypolipidemia, peroxisome proliferation, and hepatocarcinogenesis .

HY-125864D

Rabbit Fibrinogen	Interleukin Related NF-κB	Cardiovascular Disease
Rabbit Fibrinogen is a native fibrinogen from rabbit plasma. Fibrinogen is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines *MCP-1* and *MCP-1*. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

HY-173463

Sirtuin modulator 8	Sirtuin	Metabolic Disease Inflammation/Immunology
Sirtuin modulator 8 is a sirtuin modulator that can activate Sirtuin activity. Sirtuin modulator 8 significantly downregulates the expression of monocyte chemoattractant protein-1 (MCP-1) and upregulates the expression of fibroblast growth factor 21 (FGF21). Sirtuin modulator 8 regulates the expression of inflammation- and metabolism-related genes, showing potential for studying metabolic diseases (such as diabetes, obesity) and inflammatory diseases .

HY-P5523

iE-DAP	NOD-like Receptor (NLR) NF-κB Interleukin Related	Metabolic Disease
iE-DAP is a Nod1 agonist. iE-DAP activates NOD1, which in turn activates the NF-κB signaling pathway and MLCK signaling pathway, inducing cellular inflammatory responses and tight junction disruption. iE-DAP downregulates the expression of ZO-1 and Occludin genes. iE-DAP increases the secretion of IL-6, GRO-α, *MCP-1, IL-8* and MIP-1β in term human trophoblast cell cultures. iE-DAP triggers preterm birth in pregnant mice, reduces fetal body weight, and induces fetal inflammation. iE-DAP is applicable to research related to mastitis and preterm birth .

HY-RS02249

CD46 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CD46 Human Pre-designed siRNA Set A contains three designed siRNAs for CD46 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD46 Human Pre-designed siRNA Set A CD46 Human Pre-designed siRNA Set A

HY-114164F

Canine Thrombin	Thrombin Protease Activated Receptor (PAR) MMP VEGFR Epigenetic Reader Domain	Cardiovascular Disease
Canine Thrombin is a Canine serine protease that plays a central role in blood coagulation. Canine Thrombin stimulates macrophages to polarize into a unique phenotype characterized by anti-inflammatory and pro-repair properties. Canine Thrombin activates PAR1, induces the production of *MCP-1, MMP3* and VEGF in intervertebral discs, and causes degradation of the cartilage matrix and destruction of intervertebral disc structure. Canine Thrombin activity increases significantly in paraoxon-induced status epilepticus .

HY-125740R

Malvidin-3-glucoside chloride (Standard) Malvidin-3-O-glucoside chloride (Standard); Oenin chloride (Standard)	Reference Standards Interleukin Related NO Synthase NF-κB TNF Receptor	Metabolic Disease Inflammation/Immunology
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride (Standard) is the analytical standard of Malvidin-3-glucoside chloride (HY-125740). This product is intended for research and analytical applications. Malvidin-3-glucoside chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as *MCP-1, ICAM-1, and IL-6*, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .

HY-RS17880

Cd46 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Cd46 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd46 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cd46 Mouse Pre-designed siRNA Set A Cd46 Mouse Pre-designed siRNA Set A

HY-N3007R

Naringenin chalcone (Standard)	Reference Standards Drug Intermediate Apoptosis NO Synthase	Inflammation/Immunology
Naringenin chalcone (Standard) is an analytical standard of Naringenin chalcone. This product is intended for research and analytical applications. Naringenin chalcone is an orally active intermediate in the biosynthesis of flavonols. Naringenin chalcone induces apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties.

HY-179009

NOD2 agonist 4	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
NOD2 agonist 4 (Compound 12b) is a potent NOD2 agonist with an EC₅₀ of 44.1 nM. NOD2 agonist 4 induces cytokine production (MCP-1, IL-6 and IL-8) in peripheral blood mononuclear cells (PBMCs), both alone and in combination with Lipopolysaccharide (LPS) (HY-D1056). NOD2 agonist 4 can be used for the studies of NOD2-targeted immunomodulator or vaccine adjuvant .

HY-147429A

Zosurabalpin TFA Abx MCP TFA; RG6006 TFA	Antibiotic Bacterial	Infection
Zosurabalpin TFA is a tethered macrocyclic peptide antibiotic, acting specifically on A. baumannii. Zosurabalpin TFA inhibits lipopolysaccharide-transport .

HY-124665

LMP-420	TNF Receptor Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
LMP-420 is a selective tumor necrosis factor-α (TNF-α) inhibitor. LMP-420 reduces the release of pro-inflammatory cytokines (e.g., IL-1β, IL-2), inducing the expression of anti-inflammatory cytokine IL-10 and anti-apoptotic molecules SOCS-1 and Mn-SOD. LMP-420 also downregulates chemokines (e.g., IP-10, MCP-1) to reduce immune cell infiltration. LMP-420 is promising for research of type 1 diabetes mellitus, inflammatory diseases (e.g., colitis), and HIV-Mycobacterium tuberculosis coinfection .

HY-19020

FK-664	Leukotriene Receptor	Cardiovascular Disease
FK-664 is a leukotriene inhibitor. FK-664 enhances ventricular contractility and shortens the time to peak tension in cardiac cells. FK-664 reduces mean circulating pressure (MCP) in a canine model of heart failure. FK-664 can be used in research on cardiovascular diseases such as heart failure .

HY-D1419

mCP-BP-SFAC	Fluorescent Dye	Others
mCP-BP-SFAC is a luminogenic molecule. mCP-BP-SFAC exhibits strong sky-blue delayed fluorescence in neat films, with photoluminescence (PL) peaks at ~483 nm and delayed fluorescence lifetimes of 5.4 to 5.7 μs .

HY-120544

BAY-386	Protease Activated Receptor (PAR)	Inflammation/Immunology
BAY-386, a chemical probe, is a PAR-1 antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC .

HY-118312

CAY10657	NF-κB	Inflammation/Immunology
CAY10657 is an inhibitor for NF-κB pathway. CAY10657 downregulates expressions of proinflammatory cytokine (IL-6) and chemokine (MCP-1), and thus exhibits anti-inflammatory efficacy against meningitis induced by Streptococcus suis .

HY-RS01882

CAPG Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CAPG Human Pre-designed siRNA Set A contains three designed siRNAs for CAPG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CAPG Human Pre-designed siRNA Set A CAPG Human Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-125864

Fibrinogen (Bovine)

2 Publications Verification

Biochemical Assay Reagents

Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

HY-N9914

D-Psicose D-Allulose	Biochemical Assay Reagents
D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease .

HY-N9914R

D-Psicose (Standard)

D-Allulose (Standard)

Biochemical Assay Reagents

D-Psicose (Standard) is the analytical standard of D-Psicose (HY-N9914). This product is intended for research and analytical applications. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease .

Cat. No.	Product Name	Target	Research Area

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, VCAM-1, *MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces p-AMPK* and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis .

HY-12557

γ-Glutamylvaline γ-Glu-Val	Endogenous Metabolite CaSR Wnt TNF Receptor Interleukin Related PPAR β-catenin	Inflammation/Immunology
γ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced *IL‑6/MCP‑1* and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation .

HY-P5523A

iE-DAP dihydrochloride	NOD-like Receptor (NLR) NF-κB Interleukin Related	Metabolic Disease
iE-DAP dihydrochloride is a Nod1 agonist. iE-DAP dihydrochloride activates NOD1, which in turn activates the NF-κB signaling pathway and MLCK signaling pathway, inducing cellular inflammatory responses and tight junction disruption. iE-DAP dihydrochloride downregulates the expression of ZO-1 and Occludin genes. iE-DAP dihydrochloride increases the secretion of IL-6, GRO-α, *MCP-1, IL-8* and MIP-1β in term human trophoblast cell cultures. iE-DAP dihydrochloride triggers preterm birth in pregnant mice, reduces fetal body weight, and induces fetal inflammation. iE-DAP dihydrochloride can be used in studies related to mastitis and preterm birth .

HY-P5523

iE-DAP	NOD-like Receptor (NLR) NF-κB Interleukin Related	Metabolic Disease
iE-DAP is a Nod1 agonist. iE-DAP activates NOD1, which in turn activates the NF-κB signaling pathway and MLCK signaling pathway, inducing cellular inflammatory responses and tight junction disruption. iE-DAP downregulates the expression of ZO-1 and Occludin genes. iE-DAP increases the secretion of IL-6, GRO-α, *MCP-1, IL-8* and MIP-1β in term human trophoblast cell cultures. iE-DAP triggers preterm birth in pregnant mice, reduces fetal body weight, and induces fetal inflammation. iE-DAP is applicable to research related to mastitis and preterm birth .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99444

Astegolimab 2 Publications Verification MSTT 1041A; RG 6149	Interleukin Related MDM-2/p53 NF-κB	Cardiovascular Disease Inflammation/Immunology
Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody. Astegolimab blocks IL-33 signaling by targeting the IL-33 receptor ST2. Astegolimab reduces p53 expression, mitigates IL33-upregulated SASP factors such as IL1α, IL6 and *MCP1. Astegolimab mitigates IL33-increased p-p65/p65* ratio. Astegolimab blocks CM-induced neutrophil extracellular trap (NET) formation. Astegolimab is used in chronic obstructive pulmonary disease (COPD) and myocardial research .

HY-P990297

*Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5)* 1 Publications Verification	CCR HIV	Infection Inflammation/Immunology Cancer
Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) is an anti-mouse/rat/human *CCL2/MCP-1* IgG monoclonal antibody. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reverse the immunosuppressive microenvironment by blocking the CCL2 signaling pathway. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can reduce the secretion of IFN-γ and the infiltration of macrophages. CCL2/MCP-1 Antibody (2H5) can reduce the amount of HIV virus by increasing the proportion of T cells. Anti-Mouse/Rat/Human CCL2/MCP-1 Antibody (2H5) can be used for researches on inflammation conditions, virus infection and cancer such as inflammatory bowel disease (IBD), hepatocellular carcinoma (HCC) and HIV .

HY-P991426

MB-314	Transmembrane Glycoprotein IFNAR TNF Receptor	Cancer
MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0498

Bindarit Maximum Cited Publications 29 Publications Verification AF2838	Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Umbelliferae Plants Disease Research Fields Echinacea angustifolia DC. Endocrinology Source Classification Cancer	CCR
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8*, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity .

HY-33037

Phenazine-1-carboxylic acid	Infection Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Marine natural products Disease Research Fields Source Classification	Fungal
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation .

HY-N3007

Naringenin chalcone 5+ Cited Publications	Structural Classification Classification of Application Fields Plants Endogenous metabolite Human Gut Microbiota Metabolites Chalcones Flavonoids other families Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Drug Intermediate Apoptosis NO Synthase
Naringenin chalcone is an orally active intermediate in flavonol biosynthesis. Naringenin chalcone induces Apoptosis. Naringenin chalcone inhibits the production of *MCP-1* and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties .

HY-N9914

D-Psicose D-Allulose	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	p38 MAPK NF-κB
D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease .

HY-N0847

Micheliolide 5+ Cited Publications	Other Monoterpenes other families Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Source Classification	NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-N2572

Eupafolin Nepetin; 6-Methoxyluteolin	Structural Classification Classification of Application Fields Flavones Plants Compositae Flavonoids Lespedeza juncea (L. f.) Pers. Labiatae Cassia Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification	Interleukin Related
Eupafolin (Nepetin) (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Eupafolin inhibits IL-6, IL-8 and *MCP-1* secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells .

HY-125740

Malvidin-3-glucoside chloride Malvidin-3-O-glucoside chloride; Oenin chloride	Classification of Application Fields Vitis vinifera cv. Zalema Plants Vitaceae Anthocyans Flavonoids Sunscreen Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Source Classification	NF-κB TNF Receptor NO Synthase Interleukin Related
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as *MCP-1, ICAM-1, and IL-6*, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .

HY-N1940

β-Anhydroicaritin 3 Publications Verification Cycloicaritin	Flavonols Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-N9914R

D-Psicose (Standard) D-Allulose (Standard)	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards p38 MAPK NF-κB
D-Psicose (Standard) is the analytical standard of D-Psicose (HY-N9914). This product is intended for research and analytical applications. D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and *MCP-1* expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease .

HY-125740R

Malvidin-3-glucoside chloride (Standard) Malvidin-3-O-glucoside chloride (Standard); Oenin chloride (Standard)	Structural Classification Anthocyans Flavonoids Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae Source Classification	Reference Standards Interleukin Related NO Synthase NF-κB TNF Receptor
Malvidin-3-glucoside (Malvidin-3-O-glucoside; Oenin) chloride (Standard) is the analytical standard of Malvidin-3-glucoside chloride (HY-125740). This product is intended for research and analytical applications. Malvidin-3-glucoside chloride is an orally active inhibitor of the NF-κB pathway, which blocks inflammatory responses induced by TNF-α, reduces IκB-α degradation and p65 nuclear translocation, and upregulates endothelial nitric oxide synthase eNOS to increase NO production. Malvidin-3-glucoside chloride exerts anti-inflammatory and antioxidant effects by inhibiting pro-inflammatory molecules such as *MCP-1, ICAM-1, and IL-6*, and regulating intestinal microorganisms and metabolites, while protecting endothelial cells and improving intestinal microecological dysbiosis under inflammatory conditions. Malvidin-3-glucoside chloride can be used to study chronic inflammatory-related diseases such as atherosclerosis and inflammatory bowel disease, and has the potential to prevent vascular inflammation and improve intestinal health .

HY-N3007R

Naringenin chalcone (Standard)	Structural Classification Human Gut Microbiota Metabolites Chalcones Flavonoids other families Phenols Polyphenols Plants Endogenous metabolite Source Classification	Reference Standards Drug Intermediate Apoptosis NO Synthase
Naringenin chalcone (Standard) is an analytical standard of Naringenin chalcone. This product is intended for research and analytical applications. Naringenin chalcone is an orally active intermediate in the biosynthesis of flavonols. Naringenin chalcone induces apoptosis. Naringenin chalcone inhibits the production of MCP-1 and NO. Naringenin chalcone exhibits anticancer activity against glioblastoma. Naringenin chalcone has anti-inflammatory and anti-allergic properties.

HY-N2572R

Eupafolin (Standard) Nepetin (Standard); 6-Methoxyluteolin (Standard)	Structural Classification Flavonoids Lespedeza juncea (L. f.) Pers. Flavones Labiatae Cassia Phenols Polyphenols Plants Compositae Source Classification	Reference Standards Interleukin Related
Eupafolin (Standard) is the analytical standard of Eupafolin. This product is intended for research and analytical applications. Eupafolin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Eupafolin inhibits IL-6, IL-8 and MCP-1 secretion with IC₅₀ values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells .

HY-33037R

Phenazine-1-carboxylic acid (Standard)	Alkaloids Structural Classification Microorganisms Other Alkaloids Marine natural products Source Classification	Reference Standards Fungal
Phenazine-1-carboxylic acid (Standard) is the analytical standard of Phenazine-1-carboxylic acid. This product is intended for research and analytical applications. Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4].

HY-N0847R

Micheliolide (Standard)	Structural Classification Other Monoterpenes other families Terpenoids Plants Source Classification	Reference Standards NF-κB PI3K Akt TGF-beta/Smad
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .

HY-N17908

Viscumneoside V	Structural Classification Flavonols Flavonoids Viscum angulatum B.Heyne ex DC. Plants Source Classification Santalaceae	CCR
Viscumneoside V is a plant-derived anti-inflammatory agent present in Viscum album var. coloratum. Viscumneoside V inhibits the expression of *MCP-1* and promotes the production of RANTES in LPS-stimulated immune cells. Viscumneoside V can be used for research related to skin rashes .

HY-N17779

3-O-Caffeoyl-5-O-feruloylquinic acid	Structural Classification Simple Phenylpropanols Alfredia cernua (L.) Cass. Phenylpropanoids Umbelliferae Plants Source Classification	TNF Receptor Reactive Oxygen Species (ROS)
3-O-Caffeoyl-5-O-feruloylquinic acid is a quinic acid-based phenolic compound that can be isolated from Eryngium bourgatii. 3-O-Caffeoyl-5-O-feruloylquinic acid regulates free radical scavenging and inflammatory pathways, exerting antioxidant activity through electron transfer and hydrogen atom transfer mechanisms. It also inhibits TNF-α-induced reactive oxygen species (ROS) production and the production of monocyte chemoattractant protein-1 (MCP-1) and its transcripts in human umbilical vein endothelial cells (HUVECs).

HY-N10175

Berkeleyacetal C	Other Terpenoids Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase NF-κB ERK Interleukin Related TNF Receptor Reactive Oxygen Species (ROS)
keleyacetal C, a meroterpenoid compound with anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways. Berkeleyacetal C significantly inhibits the expression of iNOS and the following NO production by macrophages. Berkeleyacetal C inhibits expression and secretion of key pro-inflammatory factors and chemokines (TNF-α, IL-6, IL-1β, MIP-1α, and *MCP-1). Berkeleyacetal C also inhibits activation of neutrophils and reactive oxygen species (ROS)* production. Berkeleyacetal C can be used for the study of inflammatory disorders .

Species:	Human (19) Rat (3) Mouse (12) Cynomolgus (2) Pig (1) Canine (1)
Tag:	His (20) SUMO (1) Tag Free (15) Avi (2) Myc (1) Fc (2)
Source:	HEK293 (16) CHO (2) P. pastoris (1) Sf9 insect cells (2) E. coli (17)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75601

	CAPG Protein, Human Macrophage-capping protein; Actin regulatory protein CAP-G; CAPG; AFCP; MCP	Human	E. coli
	Macrophage-capping protein (CAPG), a ubiquitous actin-binding protein, belongs to the gelsolin/villin superfamily and is associated with cell motility. CAPG is a Ca²⁺-sensitive protein and plays a role in macrophage function and is involved in the process of metastasis by promoting the invasiveness of tumor cells. CAPG Protein, Human is the recombinant human-derived CAPG protein, expressed by E. coli , with tag free.

HY-P700681

	CD46 Protein, Cynomolgus (HEK293, His) TLX; CD46; MCP; MIC10; AHUS2; TRA2.10	Cynomolgus	HEK293
	CD46 protein is an important cofactor for complement factor I, a serine protease that protects autologous cells by cleaving deposited C3b and C4b. In addition to complement regulation, CD46 is involved in sperm-oocyte fusion during fertilization. CD46 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD46 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700680

	CD46 Protein, Canine (HEK293, His) TLX; CD46; MCP; MIC10; AHUS2; TRA2.10; Membrane cofactor; LOC609365	Canine	HEK293
	CD46 protein does not possess the conserved residue(s) necessary for propagating feature annotation. CD46 Protein, Canine (HEK293, His) is the recombinant canine-derived CD46 protein, expressed by HEK293 , with C-His labeled tag.

HY-P72723

	CD46 Protein, Human (HEK293, His) Membrane Cofactor Protein; TLX; CD46; MCP; MIC10	Human	HEK293
	CD46 protein is an important cofactor for complement factor I, a serine protease that protects autologous cells by cleaving deposited C3b and C4b. In addition to complement regulation, CD46 is involved in sperm-oocyte fusion during fertilization. CD46 Protein, Human (HEK293, His) is the recombinant human-derived CD46 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P700164AF

	*Animal-Free MCP-1/CCL2 Protein, Mouse (His)* Monocyte Chemotactic Protein-1; MCP-1; JE	Mouse	E. coli
	The MCP-1/CCL2 protein, as a CCR2 ligand, induces potent chemotactic responses and intracellular calcium mobilization in monocytes and basophils, without affecting neutrophils or eosinophils.It is critical for neuropathic pain and enhances NMDA-mediated synaptic transmission in neurons containing dopamine D1 and D2 receptors, possibly involving MAPK/ERK-dependent GRIN2B/NMDAR2B phosphorylation.Animal-Free MCP-1/CCL2 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMCP-1/CCL2 protein, expressed by E.coli , with N-His labeled tag.This product is for cell culture use only.

HY-P75923

	MCP-2/CCL8 Protein, Human (SUMO) C-C motif chemokine 8; MCP-2; SCYA10; SCYA8	Human	E. coli
	MCP-2/CCL8 Protein, Human (SUMO) is a CC chemokine that interacts with CCR1, CCR2B, CCR3, and CCR5 to mediate host inflammatory immune responses, tumorigenesis, and antiviral infections. MCP-2/CCL8 Protein, Human (SUMO) is a recombinant human MCP-2/CCL8 (Q24-P99) protein expressed by E. coli with a N-SUMO tag.

HY-P700034AF

	*Animal-Free MCP-1/CCL2 Protein, Human (His)* 3 Publications Verification C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	E. coli
	MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. Animal-Free MCP-1/CCL2 Protein, Human (His) is the recombinant human-derived animal-FreeMCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P700231AF

	*Animal-Free MCP-1/CCL2 Protein, Pig (His)* C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Pig	E. coli
	MCP-1/CCL2 protein acts as a ligand for CCR2, inducing chemotactic responses and calcium mobilization. It attracts monocytes and basophils but not neutrophils or eosinophils. Animal-Free MCP-1/CCL2 Protein, Pig (His) is the recombinant pig-derived animal-Free MCP-1/CCL2 protein, expressed by E. coli , with N-His labeled tag.This product is for cell culture use only.

HY-P700787

	MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Cynomolgus	HEK293
	MCP-1/CCL2 protein activates CCR2 and induces chemotaxis and calcium ion mobilization. It attracts monocytes and basophils, not neutrophils or eosinophils. It also contributes to neuropathic pain and enhances synaptic transmission in dopamine neurons. MCP-1/CCL2 exists as a monomer or homodimer and binds to endothelial cells through proteoglycans. It interacts with TNFAIP6 via its Link domain. MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MCP-1/CCL2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P704401

	MCP-1/CCL2 Protein, Human (HEK293, hFc) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 (human) acts as a ligand for CCR2, triggering a potent chemotactic response and intracellular calcium mobilization upon CCR2 binding. It specifically attracts monocytes and basophils while sparing neutrophils and eosinophils. MCP-1/CCL2 Protein, Human (HEK293, hFc) is the recombinant human-derived MCP-1/CCL2 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P78488

	MCP-1/CCL2 Protein, Human (HEK293, His-Avi) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (HEK293, His-Avi) is a recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P7243

	MCP-3/CCL7 Protein, Mouse 5 Publications Verification rMuMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA7	Mouse	E. coli
	MCP-3/CCL7 Protein, Mouse is a CC chemokine and elicitor that binds to CCR1, CCR2 and CCR3 to mediate antiviral, antibacterial, antitumor and other immune responses. MCP-3/CCL7 Protein, Mouse is a recombinant mouse MCP-3/CCL7 protein expressed by E.coilMCP-3/CCL7(Q24-P97).

HY-P7245

	MCP-4/CCL13 Protein, Human 1 Publications Verification rHuMCP-4/CCL13; C-C motif chemokine 13; MCP4; SCYA13	Human	E. coli
	MCP-4/CCL13 Protein, Human is a CC family chemokine with chemotactic effects on basophils, monocytes, macrophages, immature dendritic cells and T cells. CCL13 binds to CCR1, CCR2, CCR3, CCR5, and CCR11 chemokine receptors and is able to induce key immunomodulatory responses through its effects on regulatory muscle, epithelial, and endothelial cells. MCP-4/CCL13 Protein, Human is a recombinant human MCP-4/CCL13 (Q24-T98) protein expressed by E.coli.

HY-P7244

	MCP-3/CCL7 Protein, Rat rRtMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA7	Rat	E. coli
	MCP-3/CCL7 Protein, Rat is a CC chemokine and elicitor that binds to CCR1, CCR2 and CCR3 to mediate antiviral, antibacterial, antitumor and other immune responses. MCP-3/CCL7 Protein, Rat is a recombinant rat MCP-3/CCL7 protein expressed by E.coilMCP-3/CCL7 (Q24-P97).

HY-P74758

	MCP-1/CCL2 Protein, Mouse (sf9, His) C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (sf9, His) is a mouse MCP-1/CCL2 expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P78173

	MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2	Human	HEK293
	MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human MCP-1/CCL2 (Q24-T99) expressed by HEK293 with His and Avi tags at the C-terminus.

HY-P7237

	MCP-1/CCL2 Protein, Human Maximum Cited Publications 9 Publications Verification rHuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Human	E. coli
	MCP-1/CCL2 Protein, Human is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein MCP-1/CCL2 Protein, Human is a recombinant human MCP-1/CCL2(Q24-T99) expressed by E.coil.

HY-P7246

	MCP-5/CCL12 Protein, Mouse (CHO) rMuMCP-5/CCL12; C-C motif chemokine 12; MCP5; SCYA12	Mouse	CHO
	MCP-5/CCL12 protein, Mouse (CHO) is a potent monocyte-active chemokine that binds to the CCR2 chemokine receptor and is involved in allergic inflammation and host responses to pathogens. MCP-5/CCL12 protein, Mouse (CHO) is a recombinant mouse MCP-5/CCL12 (G23-G104) expressed by CHO.

HY-P76489

	MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	Sf9 insect cells
	MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (Biotinylated, sf9, His) is a biotinylated mouse MCP-1/CCL2 (M1-N148) expressed by Spodoptera frugiferda(Sf9) with a His tag at the C-terminus.

HY-P704781

	MCP-4/CCL13 Protein, Human (His) rHuMCP-4/CCL13; C-C motif chemokine 13; MCP4; SCYA13	Human	E. coli
	MCP-4/CCL13 Protein, Human (His) is the recombinant human-derived MCP-4/CCL13 protein, expressed by E. coli, with N-His tag.

HY-P7239

	MCP-2/CCL8 Protein, Mouse 2 Publications Verification rMuMCP-2/CCL8; C-C motif chemokine 8; MCP-2; SCYA10; SCYA8	Mouse	E. coli
	MCP-2/CCL8 Protein, Mouse is a CC chemokine that interacts with CCR1, CCR2B, CCR3, and CCR5 to mediate host inflammatory immune responses, tumorigenesis, and antiviral infections. MCP-2/CCL8 Protein, Mouse is a recombinant mouse MCP-2/CCL8 (G24-P97) protein expressed by E. coli.

HY-P7242

	MCP-3/CCL7 Protein, Human 2 Publications Verification rHuMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA6; SCYA7	Human	E. coli
	MCP-3/CCL7 Protein, Human is a CC chemokine and elicitor that binds to CCR1, CCR2 and CCR3 to mediate antiviral, antibacterial, antitumor and other immune responses. MCP-3/CCL7 Protein, Human is a recombinant human MCP-3/CCL7 protein expressed by E.coilMCP-3/CCL7 (Q24-L99).

HY-P7238

	MCP-2/CCL8 Protein, Human 1 Publications Verification rHuMCP-2/CCL8; C-C motif chemokine 8; MCP-2; SCYA10; SCYA8	Human	E. coli
	MCP-2/CCL8 Protein, Human is a CC chemokine that interacts with CCR1, CCR2B, CCR3, and CCR5 to mediate host inflammatory immune responses, tumorigenesis, and antiviral infections. MCP-2/CCL8 Protein, Human is a recombinant human MCP-2/CCL8 (Q24-P99) protein expressed by E. coli.

HY-P7240

	MCP-3/CCL7 Protein, Human (CHO) 1 Publications Verification rHuMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA6; SCYA7	Human	CHO
	MCP-3/CCL7 Protein, Human (CHO) is a CC chemokine and elicitor that binds to CCR1, CCR2 and CCR3 to mediate antiviral, antibacterial, antitumor and other immune responses. MCP-3/CCL7 Protein, Human (CHO) is a recombinant human MCP-3/CCL7 protein expressed by CHOMCP-3/CCL7 (Q24-L99).

HY-P7235

	MCP-1/CCL2 Protein, Mouse (HEK293) rMuMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293) is a mouse MCP-1/CCL2 (Q24-R96) expressed by HEK293.

HY-P700266

	MCP-5/CCL12 Protein, Mouse (P. pastoris, His) rMuMCP-5/CCL12; C-C motif chemokine 12; MCP5; SCYA12	Mouse	P. pastoris
	MCP-5/CCL12 protein promotes CCR2 chemokine receptor binding and contributes to physiological processes such as angiogenesis, inflammation, and monocyte chemotaxis.It is located extracellularly and is widely expressed in tissues such as the central nervous system.MCP-5/CCL12 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived MCP-5/CCL12 protein, expressed by P.pastoris , with C-His labeled tag.

HY-P704779

	MCP-2/CCL8 Protein, Human (His) rHuMCP-2/CCL8; C-C motif chemokine 8; MCP-2; SCYA10; SCYA8	Human	E. coli
	MCP-2/CCL8 Protein, Human (His) is the recombinant human-derived MCP-2/CCL8 protein, expressed by E. coli, with N-His tag.

HY-P7236

	MCP-1/CCL2 Protein, Rat (HEK293, C-His) 1 Publications Verification rRtMCP-1/CCL2; C-C motif chemokine 2; MCAF; MCP-1; SCYA2	Rat	HEK293
	MCP-1/CCL2 Protein, Rat (HEK293, His) is a small cytokine that belongs to the CC chemokine family.

HY-P704780

	MCP-3/CCL7 Protein, Human (HEK293, His) rHuMCP-3/CCL7; C-C motif chemokine 7; MCP3; SCYA6; SCYA7	Human	HEK293
	MCP-3/CCL7 Protein, Human (HEK293, His) is the recombinant human-derived MCP-3/CCL7 protein, expressed by HEK293, with C-His tag.

HY-P7771

	MCP-2/CCL8 Protein, Mouse (HEK293, His) rMuCCL8, His; C-C motif chemokine 8; Ccl8; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; MCP-2; Small-inducible cytokine A8; MCP2; Scya8	Mouse	HEK293
	MCP-2/CCL8 Protein, Mouse (HEK293, His) is a CC chemokine that interacts with CCR1, CCR2B, CCR3, and CCR5 to mediate host inflammatory immune responses, tumorigenesis, and antiviral infections. MCP-2/CCL8 Protein, Mouse (HEK293, His ) is a recombinant mouse MCP-2/CCL8 (E20-P97) protein expressed by HEK293 with a his tag.

HY-P71903

	MCP-5/CCL12 Protein, Rat C-C motif chemokine; CCL12	Rat	E. coli
	The MCP-5/CCL12 protein belongs to the intercrine beta family and is essential for chemokines involved in intercellular communication and immune responses. In this family, MCP-5/CCL12 may play a role in regulating inflammatory processes and cellular interactions. MCP-5/CCL12 Protein, Rat is the recombinant rat-derived MCP-5/CCL12 protein, expressed by E. coli , with tag free.

HY-P7770

	MCP-2/CCL8 Protein, Human (HEK293, His) 1 Publications Verification rHuCCL8, His; C-C Motif Chemokine 8; HC14; Monocyte Chemoattractant Protein 2; Monocyte Chemotactic Protein 2; MCP-2; Small-Inducible Cytokine A8; CCL8; MCP2; SCYA10; SCYA8	Human	HEK293
	MCP-2/CCL8 Protein, Human (HEK293, His) is a CC chemokine that interacts with CCR1, CCR2B, CCR3, and CCR5 to mediate host inflammatory immune responses, tumorigenesis, and antiviral infections. MCP-2/CCL8 Protein, Human (HEK293, His ) is a recombinant human MCP-2/CCL8 (Q24-P99) protein expressed by HEK293 with a his tag.

HY-P7764

	MCP-1/CCL2 Protein, Mouse Maximum Cited Publications 9 Publications Verification rMuCCL2; C-C motif chemokine 2; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; Ccl2; Scya2	Mouse	E. coli
	MCP-1/CCL2 Protein, Mouse is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse is a mouse MCP-1/CCL2 (Q24-R96) expressed by E.coil.

HY-P700541

	CCR2 Protein, Mouse (N-His, C-Myc) 1 Publications Verification CCR2; chemokine (C-C motif) receptor 2; CMKBR2; CC CKR 2; CD192; CKR2; FLJ78302; MCP 1 R; CCR2A; CCR2B; CKR2A; CKR2B; MCP-1-R; CC-CKR-2	Mouse	E. coli
	CCR2 protein is an important chemokine receptor that coordinates chemotaxis and migration by binding to CCL2, CCL7, and CCL12 and activating the PI3K cascade. In addition to chemokine signaling, CCR2 regulates T cell inflammatory cytokines, promotes Th17 cell generation, and promotes mature thymocyte output. CCR2 Protein, Mouse (N-His, C-Myc) is the recombinant mouse-derived CCR2 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P77589

	CCR2b Protein-VLP, Human (HEK293) C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2	Human	HEK293
	CCR2b Protein-VLP, Human (HEK293) is recommended for animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P77590

	CCR2b Protein-VLP, Human (Biotinylated, HEK293) C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2	Human	HEK293
	CCR2b Protein-VLP, Human (Biotinylated, HEK293) is recommended only for SPR analysis. HY-P77589 can be used in animal immunization, ELISA, PK assay. If VLP control is required, it is recommended HY-P702775. May have binding signals with Anti-His antibodies.

HY-P72757

	MCP-1/CCL2 Protein, Mouse (HEK293, His) C-C motif chemokine ligand 2; GDCF-2; HC11; HSMCR30; MCAF; SCYA2; SMC-CF	Mouse	HEK293
	MCP-1/CCL2 Protein, Mouse (HEK293, His) is a cytokine belonging to the CC chemokine family that interacts with the CCR2 chemokine receptor on the cell surface to mediate inflammatory immune responses, viral infections, and tumorigenesis. MCP-1/CCL2 Protein, Mouse (HEK293, His) is a mouse MCP-1/CCL2 expressed by HEK293 with a His tag at the C-terminus.

HY-P72020

	CD46 Protein, Human (HEK293, hFc) AHUS2; Antigen defined by monoclonal TRA 2 10; Antigen identified by monoclonal TRA 2 10; CD46; TRA2.10	Human	HEK293
	CD46 Protein serves as a cofactor for complement factor I, safeguarding cells against complement-induced harm. It aids in sperm-oocyte fusion and acts as a T-cell costimulatory factor, facilitating the formation of T-regulatory 1 cells. These cells secrete interleukin-10, suppressing immune responses and preventing autoimmunity. Pathogens can exploit CD46's immune regulation abilities to induce an immunosuppressive state in T-cells. CD46 Protein, Human (HEK293, hFc) is the recombinant human-derived CD46 protein, expressed by HEK293 , with C-hFc labeled tag.

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Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
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Appearance
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Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-W753956

Iminostilbene-d10

Iminostilbene-d₁₀ is the deuterium labeled Iminostilbene (HY-N7064). Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases .

Host:	Mouse (8) Rabbit (8)
Reactivity:	Human (16) Rat (7) Mouse (6) Monkey (2)
Application:	IHC-P (11) ICC/IF (8) IP (3) IHC-F (1) WB (14) FC (11) ELISA (12)
Isotype:	IgG,Kappa (1) IgG (7) IgG1 (8)
Conjugation:	Non-conjugated (16) Biotin (3)
Clonality:	Polyclonal (1) Monoclonal (9) Monoclonal Antibody (2) Recombinant (7)
Modification:	Unmodified (12)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84114

	CD46 Antibody (YA3811) MCP; TLX; AHUS2; MIC10; TRA2.10	IHC-P, FC, ELISA	Human
	CD46 Antibody (YA3811) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD46.

HY-P84115

	CD46 Antibody (YA3812) MCP; TLX; AHUS2; MIC10; TRA2.10	WB, ICC/IF, FC, ELISA	Human
	CD46 Antibody (YA3812) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD46.

HY-P84114A

	CD46 Antibody (YA3811)(PBS only) MCP; TLX; AHUS2; MIC10; TRA2.10	IHC-P, FC, ELISA	Human
	CD46 Antibody (YA3811) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD46.

HY-P84115A

	CD46 Antibody (YA3812)(PBS only) MCP; TLX; AHUS2; MIC10; TRA2.10	WB, ICC/IF, FC, ELISA	Human
	CD46 Antibody (YA3812) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD46.

HY-P84082

	MCP1 Antibody (YA3779) HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	MCP1 Antibody (YA3779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCP1.

HY-P84082A

	MCP1 Antibody (YA3779)(PBS only) HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30	WB, IHC-P, ICC/IF, FC, ELISA, ELISA	Human, Mouse, Rat, Monkey
	MCP1 Antibody (YA3779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCP1.

HY-P82731

	Actin Regulatory Protein CAPG Antibody (YA2476) AFCP; Capg; gCap39; HEL S 66; mbh1; MCP	WB	Human, Mouse, Rat
	Actin Regulatory Protein CAPG Antibody (YA2476) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Actin Regulatory Protein CAPG.

HY-P87858

	MCP-1 Antibody (YA7543)	WB, IHC-P, ICC/IF, IP, ELISA	Human
	MCP-1 Antibody (YA7543) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to MCP-1.

HY-P81884

	Mast Cell Chymase Antibody (YA1629) Chymase 1; Chymase; CMA1; CYH; CYM; MCP-5; MCP3P; MCPt5; MCT1; MMCP-5	WB, IHC-P	Human
	Mast Cell Chymase Antibody (YA1629) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mast Cell Chymase.

HY-P81788

	Mast Cell Tryptase Antibody (YA1533) TPS1; TPS2; TPSAB1; TPSB1; MCP 7; Mast cell protease 7; Tryptase alpha 1	WB, IHC-P, IP	Human, Mouse, Rat
	Mast Cell Tryptase Antibody (YA1533) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Mast Cell Tryptase.

HY-P81171

	MCP1 Antibody MCP-1/CCL2; C-C motif chemokine 2; CCL 2; CCL2; CCL2_HUMAN; Chemokine (C C motif) ligand 2; Chemokine C C motif ligand 2; Chemokine CC Motif Ligand 2; GDCF 2; GDCF 2 HC11; GDCF-2; GDCF2; HC11; HSMCR30; HSMCR30; JE; MCAF; MCP 1; MCP-1; MGC9434; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; SCYA2; Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je); Small inducible cytokine A2; Small inducible cytokine subfamily A (Cys Cys), member 2; Small inducible cytokine subfamily A Cys Cys member 2; Small-inducible cytokine A2; SMC CF; SMC-CF; SMCCF.	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Rat
	MCP1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to MCP1.

HY-P80385

	CCR2 Antibody (YA548) 1 Publications Verification C C chemokine receptor type 2 antibody; C C CKR 2 antibody; C-C chemokine receptor type 2 antibody; C-C CKR-2 antibody; CC chemokine receptor type 2 antibody; CC CKR 2 antibody; CC-CKR-2 antibody; CCCKR2 antibody; CCR 2 antibody; CCR-2 antibody; CCR1L antibody; CCR2 antibody; CCR2_HUMAN antibody; CCR2A antibody; CCR2B antibody; CCR5L antibody; CD192 antibody; CD192 antigen antibody; Chemokine C C motif receptor 2 antibody; Chemokine CC Motif Receptor 2 antibody; CKR 2 antibody; CKR2 antibody; CKR2A antibody; CKR2B antibody; CMKBR2 antibody; MCP 1 R antibody; MCP-1-R antibody; MCP1 RECEPTOR antibody; MCP1R antibody; Monocyte chemoattractant protein 1 receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody; Monocyte Chemotactic Protein 1 Receptor antibody	WB, IHC-P, IP, FC	Human, Mouse
	CCR2 Antibody (YA548) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CCR2.

HY-P84311

	CCR2 Antibody (YA4008) CCR2; CKR2; CCR-2; CCR2A; CCR2B; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2	WB, FC, ELISA	Human
	CCR2 Antibody (YA4008) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCR2.

HY-P84311A

	CCR2 Antibody (YA4008)(PBS only) CCR2; CKR2; CCR-2; CCR2A; CCR2B; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2	WB, FC, ELISA	Human
	CCR2 Antibody (YA4008) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCR2.

HY-P87017

	PSME2 Antibody (YA6710) 11S regulator complex beta subunit antibody; 11S regulator complex subunit beta antibody; Activator of multicatalytic protease subunit 2 antibody; Cell migration inducing protein 22 antibody; MCP activator 31 kD subunit antibody; PA28 beta antibody; PA28b antibody; PA28beta antibody; Proteasome (prosome macropain) activator subunit 2 (PA28 beta) antibody; Proteasome (prosome macropain) activator subunit 2 antibody; 11S regulator complex beta subunit antibody; 11S regulator complex subunit beta antibody; Activator of multicatalytic protease subunit 2 antibody; Cell migration inducing protein 22 antibody; MCP activator 31 kD subunit antibody; PA28 beta antibody; PA28b antibody; PA28beta antibody; Proteasome (prosome macropain) activator subunit 2 (PA28 beta) antibody; Proteasome (prosome macropain) activator subunit 2 antibody; Proteasome activator 28 beta antibody; Proteasome activator 28 subunit beta antibody; Proteasome activator complex subunit 2 antibody; Proteasome activator hPA28 subunit beta antibody; Proteasome activator subunit 2 antibody; PSME 2 antibody; PSME2 antibody; PSME2_HUMAN antibody; REG beta antibody; REG-beta antibody; REGbeta antibody;	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	PSME2 Antibody (YA6710) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSME2.

HY-P80064

	CD46 Antibody (YA532)	WB, ICC/IF, IHC-P	Human, Rat
	CD46 Antibody (YA532) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD46.

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Reactivity
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Free Sample	Yes No
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Cat. No.	Product Name		Classification

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36		Aptamers
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice .

HY-RS02249

CD46 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CD46 Human Pre-designed siRNA Set A contains three designed siRNAs for CD46 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17880

Cd46 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cd46 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cd46 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01882

CAPG Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CAPG Human Pre-designed siRNA Set A contains three designed siRNAs for CAPG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174744

Human CCR4 mRNA		mRNA Chemokine & Receptors
Human CCR4 mRNA encodes the human C-C motif chemokine receptor 4 (CCR4) protein, a member of G protein-coupled receptors family. CCR4 is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

HY-RS24349

Cd46 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cd46 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cd46 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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