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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
15+pgdh+inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "15+pgdh+inhibitor" in MCE Product Catalog:
Art. -Nr.: HY-174990
CAS. Nr.: 2927452-83-1
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Forschungsgebiete:
HW201877 is a potent and orally active 15-prostaglandin dehydrogenase (15-PGDH) inhibitor with an IC50 of 3.6 nM. HW201877 demonstrates robust cellular efficacy in elevating PGE2 levels in A549 cells and exhibits remarkable efficacy in animal models of tissue injury and fibrosis. HW201877 can be used for the study of inflammatory bowel disease (IBD), idiopathic pulmonary fibrosis (IPF) and Crohn’s disease (CD) .
Art. -Nr.: HY-176803
CAS. Nr.: 2673403-86-4
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MF-DH-300 is a 15-PGDH inhibitor that can be applicable to the research of muscle disorders such as spinal muscular atrophy (SMA).
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ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways .
Art. -Nr.: HY-119973
CAS. Nr.: 78028-01-0
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CAY10397 is a selective and orally active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor. CAY10397 can inhibit 15-PGDH-dependent endogenous metabolite production. CAY10397 blocks the selenium-dependent protective in inflammation. CAY10397 can be used for the research of colitis .
Art. -Nr.: HY-178113
CAS. Nr.: 1537192-10-1
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15-PGDH-IN-4 (Compound 40) is a 15-PGDH inhibitor with an IC50 of 1.2 nM against h15-PGDH. 15-PGDH-IN-4 functionally inhibits the activity of 15-PGDH. 15-PGDH-IN-4 can be used in the research of colitis .
Art. -Nr.: HY-116198
CAS. Nr.: 1221413-57-5
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15-PGDH-IN-2 (Compound 2) is a 15-PGDH inhibitor with an IC50 value of 0.274 nM. 15-PGDH-IN-2 can be used in research on hair loss, bone formation, gastric ulcer healing, and dermal wound healing .
Art. -Nr.: HY-174990A
CAS. Nr.: 2927452-82-0
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Forschungsgebiete:
HW201877 enantiomer is the enantiomer of HW201877 (HY-174990) and is 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with an IC50 of 12.2 nM. HW201877 enantiomer can be used for the research of inflammatory bowel disease, idiopathic pulmonary fibrosis, ulcerative colitis, and Crohn's disease .
Art. -Nr.: HY-183433
CAS. Nr.: 99435-38-8
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Ph CL 28A is a prostaglandin 15-hydroxydehydrogenase (15-PGDH) inhibitor. Ph CL 28A increases the output of PGE2, PGF2α and endogenous arachidonic acid-derived PGI2 in isolated rat lungs, reduces the output of TxB2 and LTC4 in isolated rat hearts, and exhibits protective effects in rat models of inflammation and gastric mucosal injury. Ph CL 28A can be used in research related to acute inflammation and gastric ulcers .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
