2. Others Metabolic Enzyme/Protease
  3. Drug Isomer 15-PGDH
  4. HW201877 enantiomer

HW201877 enantiomer is the enantiomer of HW201877 (HY-174990) and is 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with an IC50 of 12.2 nM. HW201877 enantiomer can be used for the research of inflammatory bowel disease, idiopathic pulmonary fibrosis, ulcerative colitis, and Crohn's disease.

For research use only. We do not sell to patients.

HW201877 enantiomer

HW201877 enantiomer Chemical Structure

CAS No. : 2927452-82-0

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HW201877 enantiomer Related Antibodies

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Description

HW201877 enantiomer is the enantiomer of HW201877 (HY-174990) and is 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with an IC50 of 12.2 nM. HW201877 enantiomer can be used for the research of inflammatory bowel disease, idiopathic pulmonary fibrosis, ulcerative colitis, and Crohn's disease[1].

In Vitro

HW201877 enantiomer (Compound 25 A) exhibits an IC50 of 12.2 nM against 15-PGDH[1].
HW201877 enantiomer dose not elevate prostaglandin E2 (PGE2) levels in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HW201877 enantiomer Related Antibodies
Molecular Weight

440.45

Formula

C22H22F2N6O2
CAS No.
SMILES

O=C1N2C=CC(N3C[C@H](C4)[C@H]4C5=CC(C(N6CCC(F)(CC6)F)=O)=CN=C35)=CC2=NN1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HW201877 enantiomer Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HW201877 enantiomer2927452-82-0 Drug Isomer15-PGDH15-Hydroxyprostaglandin dehydrogenaserodent pulmonary fibrosis modelsTyr15115-hydroxyprostaglandin dehydrogenasePhe185Tyr217Ser138prostaglandin E2murine ulcerative colitis modelsA549 cellsInhibitorinhibitorinhibit

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HW201877 enantiomer
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