99435-38-8
Chemical Structure
Ph CL 28A
- CAS No.: 99435-38-8
- Formula:C18H16N2O7
- Molecular Weight:372.33
InChIKey: LNEKRQNMORYHDX-FMQUCBEESA-N
SMILES: O=C(CC1=CC(/N=N/C2=CC(C(OC)=O)=CC(C(OC)=O)=C2)=CC=C1O)O
Biological Activity: Ph CL 28A is a prostaglandin dehydrogenase (PGDH) inhibitor. Ph CL 28A increases the output of PGE2, PGF2α and endogenous arachidonic acid-derived PGI2 in isolated rat lungs, reduces the output of TxB2 and LTC4 in isolated rat hearts, and exhibits protective effects in rat models of inflammation and gastric mucosal injury. Ph CL 28A can be used in research related to acute inflammation and gastric ulcers[3][5].
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Ph CL 28A | Ph CL 28A is a prostaglandin dehydrogenase (PGDH) inhibitor. Ph CL 28A increases the output of PGE2, PGF2α and endogenous arachidonic acid-derived PGI2 in isolated rat lungs, reduces the output of TxB2 and LTC4 in isolated rat hearts, and exhibits protective effects in rat models of inflammation and gastric mucosal injury. Ph CL 28A can be used in research related to acute inflammation and gastric ulcers. | |||||||||||||||||||||
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- [3]. Santana AC, et al. Anti-inflammatory activities of Ph CL28A in rats in vivo. European journal of pharmacology. 1993 Feb 09;231(2):237-42. [Content Brief]
- [5]. Berry CN, et al. Sulphasalazine and PhCL28A inhibit the formation of ethanol- and phenylbutazone-induced rat gastric ulcers: lack of involvement of endogenous prostaglandins?. British journal of pharmacology. 1988 Mar;93(3):465-72. [Content Brief]
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