99435-38-8
99435-38-8
Chemical Structure
Ph CL 28A
- CAS No.: 99435-38-8
- Formula:C18H16N2O7
- Molecular Weight:372.33
InChIKey: LNEKRQNMORYHDX-FMQUCBEESA-N
SMILES: O=C(CC1=CC(/N=N/C2=CC(C(OC)=O)=CC(C(OC)=O)=C2)=CC=C1O)O
Biological Activity: Ph CL 28A is a prostaglandin 15-hydroxydehydrogenase (15-PGDH) inhibitor. Ph CL 28A increases the output of PGE2, PGF2α and endogenous arachidonic acid-derived PGI2 in isolated rat lungs, reduces the output of TxB2 and LTC4 in isolated rat hearts, and exhibits protective effects in rat models of inflammation and gastric mucosal injury. Ph CL 28A can be used in research related to acute inflammation and gastric ulcers[1][2][3][4][5].
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Ph CL 28A | Ph CL 28A is a prostaglandin 15-hydroxydehydrogenase (15-PGDH) inhibitor. Ph CL 28A increases the output of PGE2, PGF2α and endogenous arachidonic acid-derived PGI2 in isolated rat lungs, reduces the output of TxB2 and LTC4 in isolated rat hearts, and exhibits protective effects in rat models of inflammation and gastric mucosal injury. Ph CL 28A can be used in research related to acute inflammation and gastric ulcers. | |||||||||||||||||||||
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References
- [1]. Berry CN, et al. Highly potent inhibition of prostaglandin 15-hydroxydehydrogenase in-vitro and of prostaglandin inactivation in perfused lung by the new azobenzene analogue, Ph CL 28A. The Journal of pharmacy and pharmacology. 1985 Sep;37(9):622-8. [Content Brief]
- [2]. Nakamura M, et al. Effects of Ph CL 28A on eicosanoid synthesis in rat isolated hearts. Prostaglandins. 1991 Oct;42(4):303-12. [Content Brief]
- [3]. Santana AC, et al. Anti-inflammatory activities of Ph CL28A in rats in vivo. European journal of pharmacology. 1993 Feb 09;231(2):237-42. [Content Brief]
- [4]. Bakhle YS, et al. Inhibitors of prostaglandin dehydrogenase (Ph CL 28A and Ph CK 61A) increase output of prostaglandins from rat isolated lung. British journal of pharmacology. 1987 Sep;92(1):189-96. [Content Brief]
- [5]. Berry CN, et al. Sulphasalazine and PhCL28A inhibit the formation of ethanol- and phenylbutazone-induced rat gastric ulcers: lack of involvement of endogenous prostaglandins?. British journal of pharmacology. 1988 Mar;93(3):465-72. [Content Brief]
