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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
2-Aminobenzothiazole
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "2-Aminobenzothiazole" in MCE Product Catalog:
Cat. No.: HY-W017424
CAS No.: 136-95-8
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2-Aminobenzothiazole acts as a caspase 3/7 activator, an anticancer cytotoxic agent, and also exhibits neurotoxicity. 2-Aminobenzothiazole drives the apoptotic pathway by activating caspase 3/7, induces mitochondrial inner membrane depolarization, and triggers both early and late apoptosis via a caspase-dependent pathway. In zebrafish models, 2-Aminobenzothiazole induces oxidative damage in brain tissues and inhibits genes related to GABA and 5-HT synthesis pathways. Long-term exposure to 2-Aminobenzothiazole impairs motor ability, social behavior, anxiety-like state and cognitive function. 2-Aminobenzothiazole can be used in studies of human laryngeal carcinoma and related neurotoxicity [2].
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14 Publications Verification
Synonyms: HOE 140 acetate
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4 Cited Publications
Cat. No.: HY-P2336A
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1 Cited Publications
Category:
Natural Products Animals Marine natural products Other marine organisms Disease Research Fields Cancer
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Cat. No.: HY-P4070
CAS No.: 1188379-43-2
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Cat. No.: HY-P5362
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Cat. No.: HY-W017424R
CAS No.: 136-95-8
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2-Aminobenzothiazole (Standard) is the analytical standard of 2-Aminobenzothiazole. This product is intended for research and analytical applications. 2-Aminobenzothiazole acts as a caspase 3/7 activator, an anticancer cytotoxic agent, and also exhibits neurotoxicity. 2-Aminobenzothiazole drives the apoptotic pathway by activating caspase 3/7, induces mitochondrial inner membrane depolarization, and triggers both early and late apoptosis via a caspase-dependent pathway. In zebrafish models, 2-Aminobenzothiazole induces oxidative damage in brain tissues and inhibits genes related to GABA and 5-HT synthesis pathways. Long-term exposure to 2-Aminobenzothiazole impairs motor ability, social behavior, anxiety-like state and cognitive function. 2-Aminobenzothiazole can be used in studies of human laryngeal carcinoma and related neurotoxicity [2] .
Cat. No.: HY-P10341
CAS No.: 1345835-12-2
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Cat. No.: HY-W018454
CAS No.: 111865-47-5
Cat. No.: HY-P11004
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Cat. No.: HY-P10472
CAS No.: 134457-28-6
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Cat. No.: HY-P4757
CAS No.: 108081-77-2
Cat. No.: HY-P11243
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Cat. No.: HY-P2434
CAS No.: 846569-60-6
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Cat. No.: HY-P5362A
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Cat. No.: HY-105168
CAS No.: 157380-72-8
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Cat. No.: HY-155007
Purity: 99.77%
DNA gyrase B-IN-2 (Compound E) is a 2-aminobenzothiazole-based DNA gyrase B inhibitor with promising activity against ESKAPE bacterial pathogens. DNA gyrase B-IN-2 showed low nanomolar inhibition of DNA gyrase (IC50 < 10 nM) and broad-spectrum antibacterial activity against pathogens belonging to the ESKAPE group, with the minimum inhibitory concentration < 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against Gram-negative E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.DNA gyrase B-IN-2 can be used for the research of infection .
Cat. No.: HY-P2075
CAS No.: 126784-34-7
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Cat. No.: HY-P10876
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Cat. No.: HY-P11901
KH-1 is a KRAS G12D/HDAC2 dual-target inhibitor with Kd values of 11.63 nM and 20.17 nM, respectively. KH-1 induces pancreatic cell apoptosis, cell cycle arrest, and inhibits cell proliferation, invasion and migration, as well as suppresses tumor growth in pancreatic cancer xenograft models. KH-1 can be used for the research of pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
