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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
80S ribosome
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "80S ribosome" in MCE Product Catalog:
162
162 Publications Verification
Cat. No.: HY-18982
CAS No.: 22862-76-6
Synonyms: Flagecidin; Wuningmeisu C
9
9 Cited Publications
Cat. No.: HY-K1056
MCE G418 Selective Antibiotic, Sterile (50 mg/mL) is an aminoglycoside antibiotic produced by Micromonospora rhodorangea. It acts by binding to the 80S subunit of the bacterial ribosome, thus inhibiting protein synthesis in both prokaryotic and eukaryotic cells.
7
7 Cited Publications
Cat. No.: HY-120088
CAS No.: 1632250-49-7
Target:
Research Areas:
PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region .
2
2 Cited Publications
Synonyms: (-)-Cephaeline; NSC 32944 free base
Synonyms: PF-00932239
R-IMPP (PF-00932239) is a PCSK9 translation inhibitor and a selective 80S ribosome binder. R-IMPP inhibits the KRAS/MEK/ERK signaling cascade. R-IMPP reduces LPS-induced nuclear translocation of NFkB P65. R-IMPP increases LDL-R levels in cells, promotes LDL-C uptake, and does not alter the secretion of transferrin or albumin. R-IMPP inhibits the growth of colorectal cancer (CRC) cells, organoids and xenografts carrying APC/KRAS mutations, as well as the number and burden of spontaneous mouse tumors. R-IMPP can be used in research related to colorectal cancer with APC/KRAS mutations, hepatic ischemia-reperfusion injury and hypercholesterolemia .
Cat. No.: HY-18982R
CAS No.: 22862-76-6
Synonyms: Flagecidin (Standard); Wuningmeisu C (Standard)
Synonyms: (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride
Cat. No.: HY-101354A
CAS No.: 2173005-10-0
Synonyms: PF-00932239 hydrochloride
Research Areas:
R-IMPP hydrochloride (PF-00932239 hydrochloride) is a PCSK9 translation inhibitor and a selective 80S ribosome binder. R-IMPP hydrochloride inhibits the KRAS/MEK/ERK signaling cascade. R-IMPP hydrochloride reduces LPS-induced nuclear translocation of NFkB P65. R-IMPP hydrochloride increases LDL-R levels in cells, promotes LDL-C uptake, and does not alter the secretion of transferrin or albumin. R-IMPP hydrochloride inhibits the growth of colorectal cancer (CRC) cells, organoids and xenografts carrying APC/KRAS mutations, as well as the number and burden of spontaneous mouse tumors. R-IMPP hydrochloride can be used in research related to colorectal cancer with APC/KRAS mutations, hepatic ischemia-reperfusion injury and hypercholesterolemia .
Synonyms: (-)-Cephaeline dihydrobromide; NSC 32944 dihydrobromide
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
