2 Results for "

AKR1B10-IN-1

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "AKR1B10-IN-1" in MCE Product Catalog:

Cat. No.: HY-139696
CAS No.: 2136579-33-2
Purity:  ≥95.0%
Target:  

Aldose Reductase

Research Areas:  

Cancer

AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells .
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Cat. No.: HY-N21682
CAS No.: 31769-65-0
Adhumulone is an α-acid derived from hops and a selective AKR1B10 inhibitor, with IC50 values of 5.41-29.27 μM and Ki values of 3.27-16.79 μM against human AKR1B10. Adhumulone inhibits AKR1B10-mediated reduction of Farnesol (HY-Y0248A) as a competitive inhibitor, and it also suppresses the reduction of DL-Glyceraldehyde (HY-128748) and Farnesal substrates. Adhumulone is useful for research on ras-dependent malignancies .
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