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Results for "

ATP synthase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ATP Synthase (23) GSK-3 (3) Acetyl-CoA synthetase (1) Adenosine Kinase (2) Adenylate Cyclase (1) Antibiotic (10) Apoptosis (7) Autophagy (5) Bacterial (16) Biochemical Assay Reagents (1) CDK (1) CXCR (1) Drug Intermediate (1) Endogenous Metabolite (6) Ferroptosis (4) Fungal (3) Glutathione Peroxidase (4) Guanylate Cyclase (1) HDAC (1) Isotope-Labeled Compounds (4) Keap1-Nrf2 (1) Mitochondrial Metabolism (2) Mitophagy (4) mTOR (4) NF-κB (1) NOD-like Receptor (NLR) (4) Oxidative Phosphorylation (2) P2X Receptor (1) PINK1/Parkin (4) Reactive Oxygen Species (ROS) (9) Reference Standards (6) Sodium Channel (4) Succinate Dehydrogenase (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (8) Infection (20) Inflammation/Immunology (9) Metabolic Disease (5) Neurological Disease (14)
Oligonucleotides:	Nucleotide Analogs (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: ATP Synthase PGE synthase Acetolactate Synthase (ALS) ATP-binding cassette (ABC) transporters ATP Citrate Lyase Thymidylate Synthase Cellulose Synthase GSK-3 Fatty Acid Synthase (FASN) Glucosylceramide Synthase (GCS) Cyclic GMP-AMP Synthase NO Synthase P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6782

Oligomycin Maximum Cited Publications 105 Publications Verification	Oxidative Phosphorylation ATP Synthase Fungal Antibiotic	Infection Cancer
Oligomycin, an antifungal antibiotic, is an inhibitor of H ⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells .

HY-14881

Bedaquiline 50+ Cited Publications TMC207; R207910	Bacterial Antibiotic	Infection
Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-15424

5-Iodotubercidin 10+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC₅₀ of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-14881A

Bedaquiline fumarate 50+ Cited Publications R403323; TMC207 fumarate; R207910 fumarate	Bacterial Antibiotic	Infection
Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.

HY-113914

9-ING-41 5+ Cited Publications Elraglusib	GSK-3 Apoptosis Autophagy	Cancer
9-ING-41 (Elraglusib) is a maleimide-based ATP-competitive and selective *glycogen synthase* kinase-3β (GSK-3β) inhibitor with an IC₅₀ of 0.71 μM. 9-ING-41 significantly leads to cell cycle arrest, autophagy and apoptosis** in cancer cells. 9-ING-41 has anticancer activity and has the potential for enhancing the antitumor effects of chemotherapeutic agents .

HY-59090

1-Azakenpaullone 3 Publications Verification 1-Akp	GSK-3	Neurological Disease Metabolic Disease
1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of *glycogen synthase* kinase-3 β (GSK-3β), with an IC₅₀** value of 18 nM .

HY-100542

D-α-Hydroxyglutaric acid disodium 4 Publications Verification Disodium (R)-2-hydroxyglutarate	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits **ATP synthase and inhibits mTOR** signaling .

HY-111651

Gboxin 4 Publications Verification	Oxidative Phosphorylation ATP Synthase Mitochondrial Metabolism	Cancer
Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F₀F₁ ATP synthase. Antitumour activity .

HY-113038

D-α-Hydroxyglutaric acid 4 Publications Verification (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits **ATP synthase and inhibits mTOR** signaling .

HY-17355A

Dexpramipexole dihydrochloride 2 Publications Verification (R)-Pramipexole dihydrochloride; R-(+)-Pramipexole dihydrochloride; KNS-760704 dihydrochloride	ATP Synthase Sodium Channel Glutathione Peroxidase NOD-like Receptor (NLR) Mitophagy Ferroptosis PINK1/Parkin Autophagy Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na_v1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more .

HY-11001

PHA-793887 4 Publications Verification	CDK Apoptosis	Cancer
PHA-793887 is a potent, ATP-competitive CDK inhibitor, can inhibit Cdk2, Cdk1, Cdk4, and Cdk9 with IC₅₀s of 8 nM, 60 nM, 62 nM and 138 nM, respectively, and also inhibits glycogen synthase kinase 3β with an IC₅₀ of 79 nM.

HY-N6784

Oligomycin B	ATP Synthase Bacterial Apoptosis Antibiotic	Infection Neurological Disease
Oligomycin B is an antibiotic that acts as a non-selective inhibitor of **ATP Synthase. Oligomycin B increases mitochondrial membrane potential. Oligomycin B induces apoptosis** and necrosis. Oligomycin B impairs the motility of Plasmopara viticola zoospores and induces their lysis. Oligomycin B inhibits Magnaporthe oryzae (wheat blast fungus) and suppresses the development of wheat blast. Oligomycin B reduces hyphal growth and spore germination of Botrytis cinerea, and protects Arabidopsis thaliana against Botrytis cinerea infection. Oligomycin B exacerbates cytotoxic brain edema in rats with cerebral cortical contusion, increases intracranial pressure and brain water content, and aggravates mitochondrial damage in these rats. Oligomycin B is used in studies related to grape downy mildew, traumatic brain injury, wheat blast, and gray mold .

HY-113273A

Diadenosine pentaphosphate pentasodium	P2X Receptor	Neurological Disease
Diadenosine pentaphosphate pentasodium is an agonist and negative modulator of the P2X1 receptor, an endogenous vasoactive purine dinucleotide that can be isolated from platelets. Diadenosine pentaphosphate pentasodium mediates negative regulation of dendrite growth and number by activating homologous and heterologous P2X1 receptors, which triggers a transient and moderate increase in intracellular calcium levels within dendritic growth cones. Diadenosine pentaphosphate pentasodium is widely present in secretory vesicles such as platelets, chromaffin cells and brain synaptosomes, and exhibits selective activity on dendrite growth of cultured hippocampal neurons, inhibiting only dendrite growth without affecting axon growth. Diadenosine pentaphosphate pentasodium has a weaker ability to compete with RcCHAD for binding to polyP than short-chain polyPs .

HY-N125722

Venturicidin A Aabomycin A1	ATP Synthase Antibiotic	Infection
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-17355B

Dexpramipexole 2 Publications Verification (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704	PINK1/Parkin Glutathione Peroxidase Sodium Channel ATP Synthase NOD-like Receptor (NLR) Mitophagy Ferroptosis Autophagy Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Dexpramipexole ((R)-Pramipexole) is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na_v1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more .

HY-128866

TBAJ-876	Bacterial	Infection
TBAJ-876 is an orally active diarylquinoline anti-Mycobacterium agent. TBAJ-876 regulates energy metabolism by targeting the c and ε subunits of Mycobacterium tuberculosis F-ATP synthase, exerts bactericidal activity against replicating Mycobacterium tuberculosis, and retains activity against strains carrying the Rv0678 mutation. TBAJ-876 undergoes N-demethylation in vivo to form its major active metabolite TBAJ-876-M3, which has lower lipophilicity and hERG potassium channel binding affinity. TBAJ-876 is well tolerated in BALB/c mice and significantly reduces the colony-forming units of Mycobacterium tuberculosis in the lungs. In addition, TBAJ-876 exhibits inhibitory activity against Mycobacterium abscessus, reduces bacterial loads in the lungs and spleens of infected mice, and shows no antagonistic effect when used in combination with common antibiotics. TBAJ-876 can be used in studies related to tuberculosis and Mycobacterium abscessus pulmonary diseases .

HY-14881AR

Bedaquiline fumarate (Standard) R403323 (Standard); TMC207 fumarate (Standard); R207910 fumarate (Standard)	Reference Standards Bacterial Antibiotic	Infection
Bedaquiline (fumarate) (Standard) is the analytical standard of Bedaquiline (fumarate). This product is intended for research and analytical applications. Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.

HY-118960

BMS-199264 hydrochloride	ATP Synthase	Cardiovascular Disease
BMS-199264 hydrochloride is an inhibitor of *F1F0 ATP* hydrolase (IC₅₀*=0.5 μM) without inhibitory effect on F1F0 ATP* synthase. BMS-199264 hydrochloride selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 hydrochloride also enhances the recovery of contractile function following reperfusion .

HY-W010918R

Adenosine 5'-diphosphate (Standard) Adenosine diphosphate (Standard); ADP (Standard)	Reference Standards Endogenous Metabolite	Others
Adenosine 5'-diphosphate (Standard) is the analytical standard of Adenosine 5'-diphosphate. This product is intended for research and analytical applications. Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors. In Vitro: Adenosine 5'-diphosphate consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells. Adenosine 5'-diphosphate is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.

HY-W587827

Thiamine triphosphoric acid ester Thiamine triphosphate	Endogenous Metabolite	Metabolic Disease
Thiamine triphosphoric acid ester (Thiamine triphosphate) is a neuroactive compound and a triphosphate derivative of vitamin thiamine. Thiamine triphosphoric acid ester exists in microorganisms, animal organs and plants. In E. coli, Thiamine triphosphoric acid ester is transiently produced under amino acid deficiency, while in mammalian cells, it is continuously produced at a low rate. Thiamine triphosphoric acid ester can be synthesized by two distinct enzymes (cytosolic AK1 and FoF1-ATP synthase in brain mitochondria). Thiamine triphosphoric acid ester plays a fundamental role in cellular metabolism or cellular signal transduction .

HY-112715

ATP synthase inhibitor 1	ATP Synthase	Cardiovascular Disease
ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F₁/F_O-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels .

HY-14881R

Bedaquiline (Standard) TMC207 (Standard); R207910 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Bedaquiline (Standard) is the analytical standard of Bedaquiline. This product is intended for research and analytical applications. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-14881S1

(Rac)-Bedaquiline-d6	Isotope-Labeled Compounds Bacterial Antibiotic	Others
(Rac)-Bedaquiline-d6 is the deuterium labeled Bedaquiline (HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-162142

BB2-50F	Bacterial Succinate Dehydrogenase Reactive Oxygen Species (ROS)	Infection
BB2-50F is an antimicrobial agent and succinate dehydrogenase and *F1Fo-ATP* synthase inhibitor. BB2-50F induces ROS. BB2-50F inhibits succinate oxidation and reduces tricarboxylic acid (TCA) cycle activity. BB2-50F inhibits the growth of Mycobacterium tuberculosis H37Rv and its auxotrophic, attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with an MIC of 8 μM .

HY-W654003

D-α-Hydroxyglutaric acid-d5 disodium Disodium (R)-2-hydroxyglutarate-d₅	Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
D-α-Hydroxyglutaric acid-d₅ disodium (Disodium (R)-2-hydroxyglutarate-d₅) is the deuterium labeled D-α-Hydroxyglutaric acid disodium (HY-100542). D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-146388

*Mtb ATP* synthase-IN-1**	Bacterial ATP Synthase	Infection
Mtb ATP synthase-IN-1 (compound 6ab) is a potent **Mycobacterium tuberculosis (Mtb) ATP synthase** inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC₅₀ > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium .

HY-15424R

5-Iodotubercidin (Standard) NSC 113939 (Standard); 5-ITu (Standard)	Adenosine Kinase Reference Standards	Cancer
5-Iodotubercidin (Standard) is the analytical standard of 5-Iodotubercidin. This product is intended for research and analytical applications. 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-N12486

Isofalcarintriol	Keap1-Nrf2 ATP Synthase	Metabolic Disease
Isofalcarintriol is a NRF2 activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-17355BS

Dexpramipexole-d3 dihydrochloride (R)-Pramipexole-d₃ dihydrochloride; R-(+)-Pramipexole-d₃ dihydrochloride; KNS-760704-d₃ dihydrochloride	Isotope-Labeled Compounds ATP Synthase Sodium Channel Glutathione Peroxidase NOD-like Receptor (NLR) Mitophagy Ferroptosis PINK1/Parkin Autophagy Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Dexpramipexole-d₃ ((R)-Pramipexole-d₃) dihydrochloride is the deuterium labeled Dexpramipexole. Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na_v1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.

HY-125637

Venturicidin B Aabomycin A2	Antibiotic Fungal ATP Synthase	Infection
Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP *synthase* complex .

HY-175412

DDTAC Dodecylmercapto-S-(poly(tris(hydroxymethyl)acrylamidomethane); H12-TAC	Biochemical Assay Reagents	Others
DDTAC (H12-TAC) is a detergent that can extract and solubilize membrane proteins. DDTAC has a thio dodecanoyl chain linked to a polar group made of Tris polyalcoholic moieties and can be utilized in extracting yeast ATP synthase from mitochondrial membranes .

HY-162804

ATP synthase inhibitor 3	Bacterial ATP Synthase	Infection
ATP synthase inhibitor 3 (compound PT6) is an orally active inhibitor of mycobacterial F-ATP synthase (IC₅₀=0.788 μM). ATP synthase inhibitor 3 inhibits the growth of Mycobacterium tuberculosis H37Rv strain (ATCC-27294) in vitro and depletes intracellular ATP levels at an IC₅₀ value of 30μM .

HY-118960A

BMS-199264	ATP Synthase	Cardiovascular Disease
BMS-199264 is an inhibitor of *F1F0 ATP* hydrolase (IC₅₀*=0.5 μM) without inhibitory effect on F1F0 ATP* synthase. BMS-199264 selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 also enhances the recovery of contractile function following reperfusion .

HY-150983

ATP synthase inhibitor 2	ATP Synthase Bacterial	Infection
ATP synthase inhibitor 2 is a Pseudomonas aeruginosa (PA) **ATP synthase inhibitor (IC₅₀*=10 μg/mL). ATP* synthase inhibitor 2 can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .

HY-150983A

ATP synthase inhibitor 2 TFA	ATP Synthase Bacterial	Infection
ATP synthase inhibitor 2 (Compound 22) TFA is a Pseudomonas aeruginosa (PA) **ATP synthase inhibitor (IC₅₀*=10 μg/mL). ATP* synthase inhibitor 2 TFA can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .

HY-172959

mPTP-IN-1	Mitochondrial Metabolism	Cardiovascular Disease
mPTP-IN-1 (Compound 14e) is a mitochondrial permeability transition pore (mPTP) inhibitor. mPTP-IN-1 blocks calcium-induced mPTP opening by targeting the C subunit of ATP synthase. mPTP-IN-1 can be used to study myocardial ischemia/reperfusion injury (IRI) .

HY-14881B

(Rac)-Bedaquiline (Rac)-TMC207; (Rac)-R207910	Bacterial	Infection
(Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-N12486A

(3S,8R,9R)-Isofalcarintriol	Others	Neurological Disease Metabolic Disease Cancer
(3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging .

HY-155754

3′-Acetate-ATP	ATP Synthase	Others
3’-Acetate-ATP, an ATP analogue, is ATP acetylation product with an maxima uv absorption at 259 nm in water at neutral pH. 3’-Acetate-ATP exerts a blocking effect on nucleic acid polymerization .

HY-134141

5-Octyl hydrogen L-glutamate	Drug Intermediate	Metabolic Disease
5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate) .

HY-162028

GaMF1.39	Bacterial	Infection
GaMF1.39 is an antimycobacterial compound, targeting the F-ATP synthase subunit γ. GaMF1.39 displays enhanced anti-tuberculosis activity in combination with ETC inhibitors .

HY-14881S2

Bedaquiline impurity 2-d6	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-161667

GSK-3β/HDAC-IN-1	GSK-3 HDAC	Neurological Disease
GSK-3β/HDAC-IN-1 (Compd 4) is a brain-penetrant and first in class dual non-ATP-competitive Glycogen Synthase Kinase 3β/Histone Deacetylases (GSK-3β/HDACs) Inhibitor with IC₅₀s of 0.142, 0.03 and 0.045 μM against GSK-3β, HDAC2 and HDAC6, respectively. GSK-3β/HDAC-IN-1 can be used for Alzheimer’s disease research .

HY-W779800

D-α-Hydroxyglutaric acid-13C5 disodium	Isotope-Labeled Compounds Endogenous Metabolite Reactive Oxygen Species (ROS) mTOR ATP Synthase	Neurological Disease
D-α-Hydroxyglutaric acid- ¹³C₅ disodium is the ¹³C-labeled D-α-Hydroxyglutaric acid (HY-113038). D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-100542R

D-α-Hydroxyglutaric acid disodium (Standard) Disodium (R)-2-hydroxyglutarate (Standard)	Reference Standards Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-17355AR

Dexpramipexole dihydrochloride (Standard) (R)-Pramipexole dihydrochloride (Standard); R-(+)-Pramipexole dihydrochloride (Standard); KNS-760704 dihydrochloride (Standard)	Reference Standards ATP Synthase Sodium Channel Glutathione Peroxidase NOD-like Receptor (NLR) Mitophagy Ferroptosis PINK1/Parkin Autophagy Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Dexpramipexole ((R)-Pramipexole) dihydrochloride (Standard) is the analytical standard of Dexpramipexole (dihydrochloride). This product is intended for research and analytical applications. Dexpramipexole dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na_v1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.

HY-180149

PRP020	ATP Synthase Bacterial	Infection
PRP020 is a potent and specific inhibitor of mycobacterial **ATP synthase. PRP020 does not inhibit acidification driven by succinate. PRP020 exihibits MIC₉₅** against M. tuberculosis of 2 μM, and it remains active against most drug-resistant mutant strains. PRP020 is highly safe and can be used in anti-tuberculosis research .

HY-183249

*Ac-CoA Synthase-IN-2*	Acetyl-CoA synthetase Fungal	Infection
Ac-CoA Synthase-IN-2 is an Ac-CoA Synthase (ACS) inhibitor and antifungal agent. Ac-CoA Synthase-IN-2 binds in the ATP/acetyl-AMP pocket of fungal and human ACS enzymes to exert competitive inhibition with ATP, and inhibits Cryptococcus neoformans CnKbc1-mediated acetoacetate-to-aceto-acetyl CoA conversion. Ac-CoA Synthase-IN-2 can be used for the research of fungal infections .

HY-183551

Antitubercular agent-59		Infection
Antitubercular agent-59 is an orally active antitubercular agent with an IC₅₀ of 51 nM against Mycobacterium tuberculosis H37Rv. Antitubercular agent-59 inhibits growth of Bedaquiline (HY-14881)-resistant Rv0678^G12C mutant strains. Antitubercular agent-59 exerts bactericidal activity in chronic tuberculosis mouse models with 1-Aminobenzotriazole (HY-103389) coadministration .

HY-147129

cGAS-IN-9	Guanylate Cyclase Adenylate Cyclase CXCR NF-κB	Inflammation/Immunology
cGAS-IN-9 is a cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) inhibitor, with IC₅₀ values of 27.5 nM and 5.15 μM against human and murine cGAS, respectively. cGAS-IN-9 shows weak inhibitory activity against human soluble adenylate cyclase, with an IC₅₀ of 26.4 μM. cGAS-IN-9 inhibits dsDNA-induced expression of IFNB1 and CXCL10, as well as activation of the NF-κB pathway, in human immune cells. cGAS-IN-9 can be used in research related to cGAS-dependent inflammatory diseases .

Cat. No.	Product Name

HY-L089

Mitochondria-Targeted Compound Library

1,100 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 1,100 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6782

Oligomycin Maximum Cited Publications 105 Publications Verification	Infection Microorganisms Antifungal Macrolide Antibiotics Classification of Application Fields Antibiotics Disease Research Anticancer Disease Research Fields Source Classification	Oxidative Phosphorylation ATP Synthase Fungal Antibiotic
Oligomycin, an antifungal antibiotic, is an inhibitor of H ⁺-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells .

HY-100542

D-α-Hydroxyglutaric acid disodium 4 Publications Verification Disodium (R)-2-hydroxyglutarate	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits **ATP synthase and inhibits mTOR** signaling .

HY-113038

D-α-Hydroxyglutaric acid 4 Publications Verification (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid	Classification of Application Fields Neurological Disease Anti-aging Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer Source Classification	Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits **ATP synthase and inhibits mTOR** signaling .

HY-N6784

Oligomycin B	Structural Classification Microorganisms Antifungal Macrolide Antibiotics Antibiotics Disease Research Source Classification	ATP Synthase Bacterial Apoptosis Antibiotic
Oligomycin B is an antibiotic that acts as a non-selective inhibitor of **ATP Synthase. Oligomycin B increases mitochondrial membrane potential. Oligomycin B induces apoptosis** and necrosis. Oligomycin B impairs the motility of Plasmopara viticola zoospores and induces their lysis. Oligomycin B inhibits Magnaporthe oryzae (wheat blast fungus) and suppresses the development of wheat blast. Oligomycin B reduces hyphal growth and spore germination of Botrytis cinerea, and protects Arabidopsis thaliana against Botrytis cinerea infection. Oligomycin B exacerbates cytotoxic brain edema in rats with cerebral cortical contusion, increases intracranial pressure and brain water content, and aggravates mitochondrial damage in these rats. Oligomycin B is used in studies related to grape downy mildew, traumatic brain injury, wheat blast, and gray mold .

HY-N125722

Venturicidin A Aabomycin A1	Infection Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	ATP Synthase Antibiotic
Venturicidin A (Aabomycin A1), from actinomycetes, is a membrane-active natural product inhibitor of ATP synthase. Venturicidin A potentiates the aminoglycoside antibiotic gentamicin against multidrug-resistant clinical isolates of Staphylococcus, Enterococcus, and Pseudomonas aeruginosa. Venturicidin A shows noticeable toxicity toward human embryonic-kidney (HEK)cells with an IC50 of 31 μg/mL.

HY-W010918R

Adenosine 5'-diphosphate (Standard) Adenosine diphosphate (Standard); ADP (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
Adenosine 5'-diphosphate (Standard) is the analytical standard of Adenosine 5'-diphosphate. This product is intended for research and analytical applications. Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P_2T-purinoceptors. In Vitro: Adenosine 5'-diphosphate consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ATP is an important energy transfer molecule in cells. Adenosine 5'-diphosphate is utilized in a wide number of cellular processes, including respiration, biosynthetic reactions, motility, and cell division.

HY-N12486

Isofalcarintriol	Natural Products Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Plants Umbelliferae Source Classification	Keap1-Nrf2 ATP Synthase
Isofalcarintriol is a NRF2 activator and selective inhibitor of the mitochondrial ATP synthase. Isofalcarintriol can be used for aging study .

HY-N12486A

(3S,8R,9R)-Isofalcarintriol	Natural Products Artemisia granatensis boiss Umbelliferae Plants Source Classification	Others
(3S,8R,9R)-Isofalcarintriol is a natural polyacetylene compound found in carrot root parts. (3S,8R,9R)-Isofalcarintriol is a potent longevity promoter that improves glucose metabolism and has anti-tumor activity. (3S,8R,9R)-Isofalcarintriol can affect cellular respiration, interact with the α subunit of mitochondrial ATP synthase, and promote mitochondrial biogenesis. (3S,8R,9R)-Isofalcarintriol can be used in the study of neurodegenerative diseases, metabolic diseases, and aging .

HY-100542R

D-α-Hydroxyglutaric acid disodium (Standard) Disodium (R)-2-hydroxyglutarate (Standard)	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Reactive Oxygen Species (ROS) ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of D-α-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

Species:	Human (9) Mouse (1) Bovine (1)
Tag:	SUMO (3) His (11) Myc (1)
Source:	E. coli Cell-free (2) P. pastoris (1) Sf9 insect cells (1) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72097

	ATP5D Protein, Human (His-SUMO) ATP synthase subunit delta; mitochondrial ; ATP synthase subunit delta; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; delta subunit; ATP5D; ATPD_HUMAN; F ATPase delta subunit ; F-ATPase delta subunit; Mitochondrial ATP synthase complex delta subunit precusor ; Mitochondrial ATP synthase delta subunit	Human	E. coli
	ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His-SUMO) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P72098

	ATP5D Protein, Human (His) ATP synthase subunit delta; mitochondrial ; ATP synthase subunit delta; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; delta subunit; ATP5D; ATPD_HUMAN; F ATPase delta subunit ; F-ATPase delta subunit; Mitochondrial ATP synthase complex delta subunit precusor ; Mitochondrial ATP synthase delta subunit	Human	E. coli
	ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-10*His labeled tag.

HY-P72095

	ATP5F1A Protein, Human (His) ATP synthase alpha chain; ATP synthase alpha chain; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle; ; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; alpha subunit; ATP5A; ATP5a1; ATP5AL2; ATPA_HUMAN; ATPM; hATP1; HEL-S-123m; MC5DN4; mitochondrial;	Human	E. coli
	ATP5F1A is an important component of mitochondrial ATP synthase (complex V) that coordinates ATP production from ADP by utilizing the transmembrane proton gradient. As part of the F-type ATPase, the α and β subunits of ATP5F1A form the catalytic core to achieve ATP hydrolysis. ATP5F1A Protein, Human (His) is the recombinant human-derived ATP5F1A protein, expressed by E. coli , with N-6*His labeled tag.

HY-P72096

	ATP5F1A Protein, Human (His-SUMO) ATP synthase alpha chain; ATP synthase alpha chain; mitochondrial; ATP synthase subunit alpha; ATP synthase subunit alpha mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; 1; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 1; cardiac muscle; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; non-cardiac muscle-like 2; ATP sythase F1 ATPase; alpha subunit; ATP5A; ATP5a1; ATP5AL2; ATPA_HUMAN; ATPM; Epididymis secretory sperm binding protein Li 123m; hATP1; HEL-S-123m; MC5DN4; mitochondrial; Mitochondrial ATP synthetase; Mitochondrial ATP synthetase oligomycin resistant; Modifier of Min 2; Modifier of Min 2 mouse homolog; Modifier of Min 2; mouse; homolog of; MOM2; OMR; ORM; OTTHUMP00000163475	Human	E. coli
	ATP5F1A is an important component of mitochondrial ATP synthase (complex V) that coordinates ATP production from ADP by utilizing the transmembrane proton gradient. As part of the F-type ATPase, the α and β subunits of ATP5F1A form the catalytic core to achieve ATP hydrolysis. ATP5F1A Protein, Human (His-SUMO) is the recombinant human-derived ATP5F1A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P702220

	ATP5J2 Protein, Human (Cell-Free, His) ATP synthase subunit f, mitochondrial; ATP synthase membrane subunit f	Human	E. coli Cell-free
	ATP5J2 protein is a component of mitochondrial membrane ATP synthase (complex V), which uses the proton gradient established by the respiratory chain electron transport complex to help ADP synthesize ATP. ATP5J2 is located in the F(0) domain as a small subunit and cooperates with subunit a in the membrane. ATP5J2 Protein, Human (Cell-Free, His) is the recombinant human-derived ATP5J2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P71550

	ATP5MG Protein, Bovine (Myc, His) ATP5MG; ATP5LATP synthase subunit g; mitochondrial; ATPase subunit g; ATP synthase membrane subunit g	Bovine	E. coli
	ATP5MG Protein, an essential part of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. Positioned within the F(0) domain as a minor subunit alongside subunit a, ATP5MG collaborates with various subunits in the overall F-type ATPase complex, including CF(1) and CF(0), to ensure efficient ATP synthesis. ATP5MG Protein, Bovine (Myc, His) is the recombinant bovine-derived ATP5MG protein, expressed by E. coli , with N-His, C-Myc labeled tag.

HY-P72070

	ACLY Protein, Human (His-SUMO) 1 Publications Verification ACL; Acly; ACLY_HUMAN; ATP citrate pro-S; lyase; ATP citrate lyase; ATP citrate synthase; ATP-citrate pro-S-; -lyase; ATP-citrate synthase; ATPcitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773	Human	E. coli
	ACLY Protein, Human (His-SUMO) is an important enzyme in the cholesterol biosynthetic pathway. ACLY produces acetyl-CoA (AcCoA) from mitochondrial citrate for cholesterol and fatty acid biosynthesis.

HY-P705696

	ACLY Protein, Human (Sf9, His) ACL; Acly; ACLY_HUMAN; ATP citrate pro-S; lyase; ATP citrate lyase; ATP citrate synthase; ATP-citrate pro-S-; -lyase; ATP-citrate synthase; ATPcitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773	Human	Sf9 insect cells
	ACLY Protein, Human (Sf9, His) is an important enzyme in the cholesterol biosynthetic pathway. ACLY produces acetyl-CoA (AcCoA) from mitochondrial citrate for cholesterol and fatty acid biosynthesis.

HY-P704166

	ATP6 Protein, Human (His) MT-ATP6; ATP6; ATPASE6; MTATP6; ATP synthase subunit a; F-ATPase protein 6	Human	E. coli
	ATP6 Protein, Human (His) is the recombinant human-derived ATP6 protein, expressed by E. coli, with N-10*His tag.

HY-P71716

	ATP5F1B Protein, Human (P.pastoris, His) ATP 5B; ATP synthase H+ transporting mitochondrial F1 complex beta polypeptide; ATPB; ATPB_HUMAN; ATPMB; ATPSB	Human	P. pastoris
	ATP5F1B protein is an important component of mitochondrial membrane ATP synthase (complex V). ATP5F1B Protein, Human (P.pastoris, His) is the recombinant human-derived ATP5F1B protein, expressed by P. pastoris , with N-His labeled tag.

HY-P705540

	Atpsckmt Protein, Mouse (Cell-Free, His) ATP synthase subunit C lysine N-methyltransferase; Protein N-lysine methyltransferase FAM173B; mFam173b; Fam173b; EC:2.1.1.-	Mouse	E. coli Cell-free

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Cat. No.	Product Name	Chemical Structure

HY-14881S1

(Rac)-Bedaquiline-d6
(Rac)-Bedaquiline-d6 is the deuterium labeled Bedaquiline (HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-W654003

D-α-Hydroxyglutaric acid-d5 disodium

D-α-Hydroxyglutaric acid-d₅ disodium (Disodium (R)-2-hydroxyglutarate-d₅) is the deuterium labeled D-α-Hydroxyglutaric acid disodium (HY-100542). D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling .

HY-17355BS

Dexpramipexole-d3 dihydrochloride

Dexpramipexole-d₃ ((R)-Pramipexole-d₃) dihydrochloride is the deuterium labeled Dexpramipexole. Dexpramipexole ((R)-Pramipexole) dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na_v1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.

HY-14881S2

Bedaquiline impurity 2-d6
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-W779800

D-α-Hydroxyglutaric acid-13C5 disodium

D-α-Hydroxyglutaric acid- ¹³C₅ disodium is the ¹³C-labeled D-α-Hydroxyglutaric acid (HY-113038). D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling .

Host:	Mouse (3) Rabbit (10)
Reactivity:	Human (13) Rat (9) Mouse (6) Monkey (2)
Application:	IHC-P (7) ICC/IF (9) IP (3) IHC-F (2) WB (13) FC (2) ELISA (1)
Isotype:	IgG (10) IgG1 (1) IgG2a (2)
Conjugation:	Non-conjugated (13)
Clonality:	Monoclonal (8) Recombinant (6)
Modification:	Unmodified (8)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81888

	ATP Synthase C Antibody (YA1633) ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1	WB, ICC/IF	Human, Mouse, Rat
	ATP Synthase C Antibody (YA1633) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Synthase C.

HY-P82460

	ATP Synthase C Antibody (YA2205) ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1	WB, IHC-P, IP	Human, Rat
	ATP Synthase C Antibody (YA2205) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Synthase C.

HY-P81888A

	ATP Synthase C Antibody (YA1633)(PBS only) ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1	WB, ICC/IF	Human, Mouse, Rat
	ATP Synthase C Antibody (YA1633) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Synthase C.

HY-P82460A

	ATP Synthase C Antibody (YA2205)(PBS only) ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1	WB, IHC-P, IP	Human, Rat
	ATP Synthase C Antibody (YA2205) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP Synthase C.

HY-P86778

	ATP5F1 Antibody (YA6471) ATP synthase F(0) complex subunit B1, mitochondrial Curated ATP synthase peripheral stalk-membrane subunit b Curated ATP synthase proton-transporting mitochondrial F(0) complex subunit B1 ATP synthase subunit b (ATPase subunit b) ATP5PB ATP5F1	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	ATP5F1 Antibody (YA6471) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ATP5F1.

HY-P86400

	ATP5A Antibody (YA6092) ATP5A1; ATP5A; ATP5AL2; ATPM; ATP synthase subunit alpha; mitochondrial	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ATP5A Antibody (YA6092) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ATP5A.

HY-P80560

	ATP Citrate Lyase Antibody (YA829) ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme	WB, ICC/IF, FC	Human, Mouse, Monkey
	ATP Citrate Lyase Antibody (YA829) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P80560A

	ATP Citrate Lyase Antibody (YA829)(PBS only) ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme	WB, ICC/IF, FC	Human, Mouse, Monkey
	ATP Citrate Lyase Antibody (YA829) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ATP Citrate Lyase.

HY-P83293

	LIG1 Antibody (YA3038) LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	LIG1 Antibody (YA3038) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LIG1.

HY-P82045

	LIG1 Antibody (YA1790) LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1	WB, IHC-P, ICC/IF	Human, Rat
	LIG1 Antibody (YA1790) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LIG1.

HY-P82954

	DNA Ligase IV Antibody (YA2699) LIG4; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4	WB	Human
	DNA Ligase IV Antibody (YA2699) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNA Ligase IV.

HY-P83293A

	LIG1 Antibody (YA3038)(PBS only) LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	LIG1 Antibody (YA3038) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LIG1.

HY-P82954A

	DNA Ligase IV Antibody (YA2699)(PBS only) LIG4; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4	WB	Human
	DNA Ligase IV Antibody (YA2699) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to DNA Ligase IV.