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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
Atg5 Inhibitors
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "Atg5 Inhibitors" in MCE Product Catalog:
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Target:
Research Areas:
Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .
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Category:
Flavonols Flavonoids Myrtaceae Phenols Polyphenols Plants Disease Research Fields Syzygium aromaticum Cancer
Target:
Cat. No.: HY-W018791R
CAS No.: 73536-69-3
Synonyms: DDB (Standard)
Research Areas:
Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .
Cat. No.: HY-183848
CAS No.: 2841473-98-9
ATG5/TECAIR-IN-4 is an ATG5-targeting autophagy inhibitor. ATG5/TECAIR-IN-4 exhibits weak autophagy inhibitory activity. ATG5/TECAIR-IN-4 could be used in cancer-related research .
Cat. No.: HY-183826
CAS No.: 2841473-91-2
ATG5 PPI-IN-4 is an autophagy inhibitor targeting ATG5, with an IC50 of 12.78 μM against ATG5-ATG16L1 and an IC50 of 12.00 μM against ATG5-TECAIR. ATG5 PPI-IN-4 blocks the protein interactions between ATG5 and ATG16L1, as well as between ATG5 and TECAIR, disrupts the assembly of the ATG12-ATG5-ATG16L1 ternary complex, inhibits the lipidation modification of LC3/ATG8, and ultimately downregulates cellular autophagy levels. ATG5 PPI-IN-4 can be used in autophagy-related research, such as studies on infection and cancer .
Cat. No.: HY-183737
CAS No.: 2841473-83-2
ATG5/TECAIR-IN-1 is a ATG5-TECAIR interaction inhibitor with an IC50 of 20.79 μM. ATG5/TECAIR-IN-1 inhibits autophagy. TG5/TECAIR-IN-1 is applicable to research on modulating protein-protein interactions to intervene in autophagy-related diseases, such as infectious diseases and cancers .
Cat. No.: HY-170594
CAS No.: 3105301-97-8
Antitumor agent-192 (Compound 2f) is a β-carboline antitumor agent. Antitumor agent-192 induces autophagy in HCT116 cells via the ATG5/ATG7 pathway. Antitumor agent-192 has an IC50 of less than 5 μM for human tumor cell lines and significantly inhibits tumor development and reduces tumor weight in a mouse colorectal cancer model transplanted with allografts [1].
Cat. No.: HY-157548
Antitumor agent-133 (compound 4d) is a bis-isatin derivative, with activities against Huh1 (IC50=17.13 μM) and Huh7 (IC50=8.27 μM). Antitumor agent-133 induces cell autophagy and inhibits tumor growth through regulation of LC3BII, ATG5 and p62 proteins .
Cat. No.: HY-183827
CAS No.: 2841473-97-8
ATG5 PPI-IN-5 is a Autophagy-Related ATG5 protein-protein interaction inhibitor and autophagy inhibitor. The IC50 values of ATG5 PPI-IN-5 for the interactions of ATG5-ATG16L1 and ATG5-TECAIR are >33 μM .
Cat. No.: HY-183828
CAS No.: 2841473-95-6
ATG5/TECAIR-IN-2 is an ATG5 inhibitor with target IC50 values >33 μM.ATG5/TECAIR-IN-2 disrupts protein-protein interactions between ATG5 and ATG16L1, and between ATG5 and TECAIR.ATG5/TECAIR-IN-2 inhibits autophagy in mammalian cells .
Cat. No.: HY-183829
CAS No.: 2841473-79-6
ATG5/TECAIR-IN-3 is a ATG5 inhibitor with autophagy inhibitory activity. ATG5/TECAIR-IN-3 selectively inhibits the ATG5-TECAIR interaction (IC50=31.24 μM) and shows no activity against the ATG5-ATG16L1 interaction .
Cat. No.: HY-183867
CAS No.: 2841473-87-6
ATG5 PPI-IN-6 is an inhibitor of ATG5 interactions with other proteins, with an IC50 value of 26.92 μM against ATG5-ATG16L1 and 16.34 μM against ATG5-TECAIR. ATG5 PPI-IN-6 inhibits Autophagy in cells .
Cat. No.: HY-183731
CAS No.: 2841473-89-8
ATG5 PPI-IN-1 is a ATG5 protein-protein interaction inhibitor, with an IC50 of 27.43 μM for the ATG5-ATG16L1 interaction and an IC50 of 14.88 μM for the ATG5-TECAIR interaction .
Cat. No.: HY-183732
CAS No.: 2841473-85-4
ATG5 PPI-IN-2 is a selective inhibitor of ATG5-TECAIR protein-protein interaction, with a IC50 of 19.16 μM. ATG5 PPI-IN-2 also acts as an Autophagy inhibitor .
Cat. No.: HY-183835
CAS No.: 2841473-75-2
Autophagy-IN-10 is an Autophagy inhibitor and an inhibitor of ATG5 interaction with other proteins, with an IC50 value of 2.29 μM against ATG5-ATG16L1 and an IC50 value of 3.68 μM against ATG5-TECAIR .
Cat. No.: HY-183833
CAS No.: 2841473-77-4
Autophagy-IN-9 is a ATG5 inhibitor with an IC50 of 21.29 μM against ATG5-TECAIR. Autophagy-IN-9 blocks the binding of ATG5 to the hot-spot amino acid residues of TECAIR protein, disrupts the assembly of ATG5-related ternary complexes, inhibits autophagosome formation, and thereby downregulates cellular autophagy levels. Autophagy-IN-9 can be used in autophagy-related research, such as studies on infection .
Cat. No.: HY-183838
CAS No.: 2841473-96-7
Autophagy-IN-11 is an ATG5-targeting autophage inhibitor. Autophagy-IN-11 disrupts protein-protein interactions between ATG5 and ATG16L1, and between ATG5 and TECAIR. Autophagy-IN-11 can be used for cancer research .
Cat. No.: HY-W768347
Synonyms: Xylite-13C5
Cat. No.: HY-183736
CAS No.: 2841473-93-4
Autophagy-IN-12 is a Autophagy inhibitor. Autophagy-IN-12 exhibits an IC50 value of >33 μM against the protein-protein interactions of ATG5-ATG16L1 and ATG5-TECAIR .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
