3105301-97-8
3105301-97-8
Chemical Structure
Antitumor agent-192
- CAS. Nr.: 3105301-97-8
- Formula:C36H54N6
- Molecular Weight:570.85
InChIKey: VBDBETBLUUSEOJ-UHFFFAOYSA-N
SMILES: CCN(CCCNCC1=NC(CNCCCN(CC)CC)=CC2=C1N(CCCC3=CC=CC=C3)C4=CC=CC=C24)CC
Biological Activity: Antitumor agent-192 (Compound 2f) is a β-carboline antitumor agent. Antitumor agent-192 induces autophagy in HCT116 cells via the ATG5/ATG7 pathway. Antitumor agent-192 has an IC50 of less than 5 μM for human tumor cell lines and significantly inhibits tumor development and reduces tumor weight in a mouse colorectal cancer model transplanted with allografts[1].
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Antitumor agent-192 | Antitumor agent-192 (Compound 2f) is a β-carboline antitumor agent. Antitumor agent-192 induces autophagy in HCT116 cells via the ATG5/ATG7 pathway. Antitumor agent-192 has an IC50 of less than 5 μM for human tumor cell lines and significantly inhibits tumor development and reduces tumor weight in a mouse colorectal cancer model transplanted with allografts. | |||||||||||||||||||||
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