Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Auristatin F
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Auristatin F" in MCE Product Catalog:
Target:
Research Areas:
Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .
8
8 Cited Publications
Synonyms: Maleimidocaproyl monomethylAuristatin F
Research Areas:
McMMAF (Maleimidocaproyl monomethylauristatin F) is an active molecule linker for ADC, made by coupling the powerful microtubule inhibitor Monomethyl auristatin F (MMAF) (HY-15579) with the protecting group maleimidocaproyl. McMMAF can be conjugated with anti-BCMA antibodies to form J6M0-mcMMAF, promoting apoptosis and inhibiting tumor growth .
1
1 Cited Publications
Cat. No.: HY-79256
CAS No.: 863971-12-4
Synonyms: Monomethyl Auristatin F methyl ester
Target:
Research Areas:
MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4 -) cell lines, respectively.
Cat. No.: HY-128711
Purity: 98.02%
Target:
Research Areas:
MAL-di-EG-Val-Cit-PAB-MMAF consists the ADCs linker (MAL-di-EG-Val-Cit-PAB) and potent tubulin polymerization blocker (MMAF, Monomethyl auristatin F) .
Cat. No.: HY-171544
Synonyms: AGS-16M8F
Cat. No.: HY-W190923
CAS No.: 2353409-70-6
Target:
Research Areas:
MMAF-methyl ester is a methylated derivative of the tubulin inhibitor MMAF (HY-15579), and serves as a pharmaceutical intermediate for the development of antibody-drug conjugates (ADCs) and small-molecule drug conjugates (SMDCs) .
Cat. No.: HY-177541
CAS No.: 2669084-60-8
Research Areas:
Ledadotin is a drug-linker conjugate for ADC. Ledadotin consists of a Microtubule inhibitor (Auristatin F-hydroxypropylamide) (HY-P5191) and a linker (BCN-PEG2-Gly-NH-tri(βAla-GGGG-Ser(mPEG8)-βAla-γGlu-Ala)) (HY-177562). Ledadotin can be used for synthesis of ADC Emiltatug ledadotin (HY-177542) .
Cat. No.: HY-15583S
Purity: 99.82%
Cat. No.: HY-W142140
CAS No.: 2566-32-7
Synonyms: N-Methylvaline
Target:
Research Areas:
Cat. No.: HY-162068
CAS No.: 2375388-36-4
Target:
Research Areas:
Auristatin23, a conjugate of Auristatin F (HY-15583), is a cytotoxin. Auristatin23 exhibit cytotoxic activities towards targeted cells, including abnormal cells such as cancer cells, that are MDR+ .
Cat. No.: HY-W142140A
Synonyms: N-Methylvaline hydrochloride
Target:
Research Areas:
N-Methyl-DL-valine (N-Methylvaline) hydrochloride is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine hydrochloride involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability .
Cat. No.: HY-P81057
Synonyms: MonomethylAuristatin F, Monomethyl Auristatin F, 745017-94-1
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
