Search Result

Results for "

BGC-823

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (2) Akt (2) Apoptosis (12) Atg7 (1) Autophagy (4) Bacterial (1) Bcl-2 Family (1) DNA/RNA Synthesis (1) Dopamine Receptor (2) Drug Derivative (3) EGFR (1) Histone Demethylase (1) Histone Methyltransferase (1) Interleukin Related (1) mAChR (1) MMP (1) NF-κB (2) PAK (1) PARP (1) PD-1/PD-L1 (1) PI3K (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) STAT (3) TRP Channel (1) TrxR (2) Wnt (1) YAP (2) β-catenin (1)
By Research Areas:	Cancer (32) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (2)

By Targets:

5-HT Receptor (2)

Adrenergic Receptor (2)

Akt (2)

Apoptosis (12)

Atg7 (1)

Autophagy (4)

Bacterial (1)

Bcl-2 Family (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (2)

Drug Derivative (3)

EGFR (1)

Histone Demethylase (1)

Histone Methyltransferase (1)

Interleukin Related (1)

mAChR (1)

MMP (1)

NF-κB (2)

PAK (1)

PARP (1)

PD-1/PD-L1 (1)

PI3K (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

STAT (3)

TRP Channel (1)

TrxR (2)

Wnt (1)

YAP (2)

β-catenin (1)

By Research Areas:

Cancer (32)

Cardiovascular Disease (1)

Infection (1)

Inflammation/Immunology (5)

Metabolic Disease (1)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14543

Sertindole 3 Publications Verification Lu 23-174	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy	Neurological Disease Cancer
Sertindole (Lu 23-174) is an orally active 5-HT_2A, 5-HT_2C, dopamine D₂, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

HY-100958

4-DAMP 4 Publications Verification 4-DAMP methiodide	mAChR Apoptosis MMP EGFR Interleukin Related	Inflammation/Immunology Cancer
4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion .

HY-N0279

Cardamonin 15+ Cited Publications Cardamomin; Alpinetin chalcone	NF-κB STAT Wnt β-catenin Bcl-2 Family Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Cardamonin can be found from cardamom, and can target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities .

HY-P1727

Super-TDU 5+ Cited Publications	YAP	Cancer
Super-TDU is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU suppresses tumor growth in gastric cancer mouse model .

HY-N4148

Purpureaside C	DNA/RNA Synthesis Apoptosis Bacterial	Infection Inflammation/Immunology Cancer
Purpureaside C, phenolic glycoside, is a minichromosome maintenance complex component 6 (MCM6) inhibitor. Purpureaside C binds to the ATP-pocket of MCM6, suppresses MCM6 protein expression in gastric cancer cells. Purpureaside C suppresses gastric cancer cell growth and induces apoptosis. Purpureaside C exerts antibacterial activity and proinflammatory activity. Purpureaside C can be used for the researches of gastric cancer, bacterial infection and inflammation .

HY-168608

TRPM7-IN-1	TRP Channel Apoptosis PI3K Akt	Cancer
TRPM7-IN-1 (compound SUD), a benzoylurea derivative, is an effective TRPM7 inhibitor. TRPM7-IN-1 induces cell cycle arrest and apoptosis, decreases the migration of MCF-7 and BGC-823 cells. TRPM7-IN-1 decreases vimentin expression and increases E-cadherin expression. TRPM7-IN-1 potentially reduces the TRPM7-like current and decreases TRPM7 expression through the PI3K/Akt signaling pathway. TRPM7-IN-1 is a potential agent to suppress the metastasis of breast and gastric cancer by inhibiting TRPM7 expression and function .

HY-149390

TrxR1-IN-1	TrxR	Cancer
TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor (IC₅₀: 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC₅₀s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical .

HY-155115

LSD1-IN-27 1 Publications Verification	Histone Demethylase PD-1/PD-L1	Cancer
LSD1-IN-27 is an orally active LSD1 inhibitor (IC₅₀: 13 nM). LSD1-IN-27 inhibits the stemness and migration of gastric cancer cells. LSD1-IN-27 also reduces the expression of PD-L1 in BGC-823 and MFC cells. LSD1-IN-27 can enhance T cell immune response in gastric cancer .

HY-163924

Apoptosis inducer 25	Apoptosis	Cancer
Apoptosis inducer 25 (Compound 4H) inhibits the proliferation of cell BGC-823 with IC₅₀ of 0.37 μM. Apoptosis inducer 25 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 25 exhibits good pharmacokinetic properties in rats .

HY-N16377

1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione	Others	Cancer
1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione (Compound 2) is an anthraquinone analog. 1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione can be isolated from soil Actinomycete Streptomyces. 1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione has potent cytotoxicity against HepG2, A875, BGC-823 and MCF-7 cells with IC₅₀s of 2.29, 4.90, 0.99 and 1.66 μg/mL, respectively. 1-Butyl-3,5,8-trihydroxy-9,10-anthracenedione has an antitumor activity .

HY-124398

GL-1196	PAK	Cancer
GL-1196 is an inhibitor of PAK4. GL-1196 can suppress the proliferation and invasion of gastric cancer cells. GL-1196 inhibits PAK4-mediated signaling pathways. GL-1196 can hinder the proliferation of human gastric cancer cells through suppressing PAK4/c-Src/EGFR/CyclinD1 and CDK4/6. GL-1196 can reduce filamentous pseudopodia formation and induce filamentous pseudopodia formation and promote cell elongation in SGC7901 and BGC823 cells. GL-1196 can be studied in anti-cancer research .

HY-175542

KB-15	STAT Apoptosis Reactive Oxygen Species (ROS) PARP	Cancer
KB-15 is a STAT3 inhibitor. KB-15 exhibits potent anti-proliferative activity against AGS gastric cancer cells (IC₅₀ = 0.29 μM) and BGC-823 gastric cancer cells (IC₅₀ = 0.65 μM). KB-15 exerts anti-tumor effects by inhibiting STAT3 phosphorylation, downregulating HO-1 expression, and promoting intracellular ROS accumulation. KB-15 induces G0/G1 phase cell cycle arrest and apoptosis, as well as suppresses colony formation and migration of gastric cancer cells. KB-15 demonstrates excellent anti-tumor efficacy in BGC-823 subcutaneous xenograft model. KB-15 can be used for the study of gastric cancer .

HY-163923

Apoptosis inducer 24	Apoptosis	Cancer
Apoptosis inducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with IC₅₀ of 1.2-4.8 μM. Apoptosis inducer 24 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 24 exhibits antitumor efficacy in mice, without significant toxicity (LD₅₀ is 91.2 mg/kg) .

HY-N12033

4'-Demethylpodophyllotoxone	Others	Cancer
4'-Demethylpodophyllotoxone is an intermediate product of the biotransformation of Alternaria alternata S-f6. After 4'-Demethylpodophyllotoxone is modified with 4-(2,3,5,6-tetramethylpyrazine-1) (4-TMP), the resulting novel compound can strongly inhibit the growth of human gastric cancer cell line (BGC-823) .

HY-N11957

Angeloylbinankadsurin A	Others	Inflammation/Immunology
Angeloylbinankadsurin A (compound 7) is an anti-rheumatoid arthritis (RA) agent that can be isolated from EtOAc and CH2Cl2 extracts of Black Tiger Beard. Angeloylbinankadsurin A exhibits inhibitory activity on RA-FLS cells (IC₅₀=11.70 μM). Angeloylbinankadsurin A is slightly toxic to human cancer cell lines (Hela and BGC-823) (IC₅₀=19.9 μM, 21.93 μM) .

HY-152228

SMYD3-IN-2	Histone Methyltransferase Autophagy	Cancer
SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC₅₀ values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer .

HY-120914

TrxR1-IN-B19 GO-Y015	TrxR Apoptosis	Cancer
TrxR1-IN-B19 (GO-Y015) (Compound B19) is a Curcumin (HY-N0005) derivative and colvalent TrxR1 inhibitor. TrxR1-IN-B19 inhibits TrxR1 enzyme activity to elevate oxidative stress, and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis .

HY-N16393

(-)-Mitorubrinol Mitorubrinol	Others	Cancer
(-)-Mitorubrinol is found in the marine-derived Penicillium purpurogenum G59 strain induced by diethyl sulfate (DES). (-)-Mitorubrinol exhibits inhibitory effects on K562, HL-60, HeLa, and BGC-823 cancer cell lines .

HY-147682

NF-κB-IN-5	NF-κB Apoptosis	Cancer
NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC₅₀ values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase .

HY-177967

Antitumor agent-209	Drug Derivative	Cancer
Antitumor agent-209 (Compound 10g), a quinolone derivative, is an antitumor agent. Antitumor agent-209 can inhibit proliferation of HCT-116, RKO, DLD1, HepG2, BGC-823, NCI-H1650 and SK-OV-3 cells with IC₅₀ values of 0.37, 0.58, 0.81, 0.79, 0.89, 0.78 and 0.89 μM .

HY-W098807

4-Chloro-7-ethoxyquinoline	Drug Derivative	Cancer
4-Chloro-7-ethoxyquinoline (Compound 9a), a quinolone derivative, is an anticancer agent. 4-Chloro-7-ethoxyquinoline can inhibit proliferation of HCT-116, RKO, DLD1, HepG2, BGC-823, NCI-H1650 and SK-OV-3 cells with IC₅₀ values of 3.16, 3.87, 2.75, 2.66, 3.91, 3.34 and 3.46μM .

HY-161351

STAT3/AKT-IN-1	Akt STAT Apoptosis	Cancer
STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells .

HY-P1727A

Super-TDU TFA	YAP	Cancer
Super-TDU TFA is a specific YAP antagonist targeting YAP-TEADs interaction. Super-TDU TFA suppresses tumor growth in gastric cancer mouse model .

HY-N16669

Cathyanin B	Others	Cancer
Cathyanin B (Compound 7) is a flavonoid found in Morus cathayana. Cathyanin B can be used for the research of cancer, such as lung cancer .

HY-N16667

Cathyanin C	Others	Cancer
Cathyanin C (Compound 8) is a flavonoid found in Morus cathayana. Cathyanin C can be used for the research of cancer .

HY-146046

Antitumor agent-56	Apoptosis	Inflammation/Immunology Cancer
Antitumor agent-56 (Compound 33) is a triptolide derivative with antitumor, anti-inflammatory and NO release activities. Antitumor agent-56 significantly inhibits the growth of melanoma. Antitumor agent-56 is orally active .

HY-173133

Antitumor agent-199	Autophagy Atg7	Cancer
Antitumor agent-199 (Compound 4b) is an antitumor agent. Antitumor agent-199 exhibits significant antiproliferative activity against multiple tumor cell lines. Antitumor agent-199 can induce autophagy in cancer cells via the ATG5/ATG7 pathway and can be used in the study of cancer .

HY-14543R

Sertindole (Standard) Lu 23-174 (Standard)	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy Reference Standards	Neurological Disease Cancer
Sertindole (Standard) is the analytical standard of Sertindole. This product is intended for research and analytical applications. Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

HY-N17466

(7S,7′R,8S,8′S)-neo-Olivil	Others	Cancer
(7S,7′R,8S,8′S)-neo-Olivil is a lignan present in the rhizome of Iris tectorum. (7S,7′R,8S,8′S)-neo-Olivil shows no significant cytotoxicity against human tumor cells at a concentration of 10 μM .

HY-N18174

Glaucogenin E	Others	Others
Glaucogenin E is a C₂₁ steroid sapogenin found in rhizomes of Cynanchum stauntonii (Decne.) Schltr. ex Levl. Glaucogenin E shows no cytotoxic activity against human cancer cells .

HY-N18229

Hirundoside A	Others	Cancer
Hirundoside A is a steroidal glycoside found in the roots of Cynanchum stauntonii .

HY-N17995

GypenosideZ-3	Others	Cancer
GypenosideZ-3 is a dammarane triterpene glycoside found in the roots of Machilus yaoshansis .

HY-N16869

Plantagiolide B	Drug Derivative	Others
Plantagiolide B is a natural steroid.

HY-182260

Apoptotic agent-5	Apoptosis	Cancer
Apoptotic agent-5 is an apoptosis inducer that releases large amounts of nitric oxide to induce cell apoptosis. Apoptotic agent-5 can be used in research related to triple-negative breast cancer .

HY-N18228

Stauntoside Ⅱ	Others	Cancer
Stauntoside Ⅱ is a 14,15-secopregnane-type C21 steroidal glycoside found in the roots of Cynanchum stauntonii. Stauntoside Ⅱ does not exhibit cytotoxic activity against human colon, hepatoma, gastric, lung, and ovarian cancer cells .

Cat. No.	Product Name	Target	Research Area