2. NF-κB Apoptosis
  3. NF-κB Apoptosis
  4. NF-κB-IN-5

NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase.

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NF-κB-IN-5

NF-κB-IN-5 Chemical Structure

CAS No. : 2425675-52-9

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NF-κB-IN-5 Related Antibodies

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Description

NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase[1].

Cellular Effect
Cell Line Type Value Description References
BGC-823 IC50
2.02 μM
Compound: 4d
Antiproliferation activity against human BGC823 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Antiproliferation activity against human BGC823 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 32546298]
HCT-116 IC50
5.35 μM
Compound: 4d
Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Antiproliferation activity against human HCT116 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 32546298]
HepG2 IC50
2.83 μM
Compound: 4d
Antiproliferation activity against human HepG2 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Antiproliferation activity against human HepG2 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 32546298]
PC-9 IC50
3.9 μM
Compound: 4d
Antiproliferation activity against human PC9 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Antiproliferation activity against human PC9 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 32546298]
U-87MG ATCC IC50
2.81 μM
Compound: 4d
Antiproliferation activity against human U87MG cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Antiproliferation activity against human U87MG cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 32546298]
In Vivo

NF-κB-IN-5 (C57BL/6 mice bearing MC38, 40.0 mg/kg, PO, for 12 days, once a day) shows promising antitumor activity against mice colon tumor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

409.48

Formula

C23H27N3O4
CAS No.
SMILES

O=C(N/N=C/C1=C/CC[C@]2(C)[C@@]([C@@]([C@](CC1)([H])C3=C)([H])OC3=O)([H])O2)NC4=CC=C(C)C=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NF-κB-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-52425675-52-9NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBcolon tumorMC38HCT116U87-MGHepG2BGC823PC9antitumor activityparthenolidesemicarbazoneInhibitorinhibitorinhibit

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