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Cat. No.: HY-163923

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Apoptosis inducer 24

Apoptosis inducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with IC₅₀ of 1.2-4.8 μM. Apoptosis inducer 24 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 24 exhibits antitumor efficacy in mice, without significant toxicity (LD₅₀ is 91.2 mg/kg).

For research use only. We do not sell to patients.

CAS No.: 2763063-09-6
Formula: C₅₅H₇₀BNO₉
Molecular Weight:899.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Apoptosis inducer 24 Chemical Structure

CAS No.: 2763063-09-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BGC-823	IC₅₀	1.2 μM Compound: 4	Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation preincubated with H2O2 for 2 hrs followed by compound addition and measured after 48 hrs by MTT assay Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation preincubated with H2O2 for 2 hrs followed by compound addition and measured after 48 hrs by MTT assay	[PMID: 39091011]
BGC-823	IC₅₀	2.3 μM Compound: 4	Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
GES1	IC₅₀	4.5 μM Compound: 4	Cytotoxicity against human GES1 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human GES1 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
HepG2	IC₅₀	6.5 μM Compound: 4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
L02	IC₅₀	6.5 μM Compound: 4	Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
MCF-10A	IC₅₀	5 μM Compound: 4	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
MCF7	IC₅₀	2.9 μM Compound: 4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
MGC-803	IC₅₀	3.6 μM Compound: 4	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
NCI-N87	IC₅₀	2.5 μM Compound: 4	Antiproliferative activity against human NCI-N87 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-N87 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
SGC-7901	IC₅₀	3.2 μM Compound: 4	Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]

Chemical Information

CAS No. 2763063-09-6
Molecular Weight 899.96
Formula C₅₅H₇₀BNO₉
SMILES

O=C1C(C#N)=C[C@]2([C@]([H])(C1(C)C)CC[C@](C)(C2=CC3=O)[C@]4([C@]3([C@]5([C@@](C(OCCCCOC(C6=CC=C(C=C6)OCC7=CC=C(C=C7)B8OC(C)(C(C)(O8)C)C)=O)=O)(CC4)CCC(C)(C5)C)[H])[H])C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li N, et al., New CDDO Arylboronate Ester Derivatives with High Selectivity and Low Toxicity. J Med Chem. 2024 Aug 22;67(16):14329-14344. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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