Apoptosis inducer 24

Cat. No.: HY-163923: Data Sheet Handling Instructions
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Apoptosis inducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with IC₅₀ of 1.2-4.8 μM. Apoptosis inducer 24 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 24 exhibits antitumor efficacy in mice, without significant toxicity (LD₅₀ is 91.2 mg/kg).

For research use only. We do not sell to patients.

Apoptosis inducer 24 Chemical Structure

CAS No. : 2763063-09-6

Size	Stock	Quantity
1 mg	Get quote 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	Get quote 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 3 - 4 Weeks 4 - 5 Weeks 5 - 6 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BGC-823	IC₅₀	1.2 μM Compound: 4	Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation preincubated with H2O2 for 2 hrs followed by compound addition and measured after 48 hrs by MTT assay Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation preincubated with H2O2 for 2 hrs followed by compound addition and measured after 48 hrs by MTT assay	[PMID: 39091011]
BGC-823	IC₅₀	2.3 μM Compound: 4	Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human BGC-823 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
GES1	IC₅₀	4.5 μM Compound: 4	Cytotoxicity against human GES1 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human GES1 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
HepG2	IC₅₀	6.5 μM Compound: 4	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
L02	IC₅₀	6.5 μM Compound: 4	Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human L02 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
MCF-10A	IC₅₀	5 μM Compound: 4	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
MCF7	IC₅₀	2.9 μM Compound: 4	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
MGC-803	IC₅₀	3.6 μM Compound: 4	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
NCI-N87	IC₅₀	2.5 μM Compound: 4	Antiproliferative activity against human NCI-N87 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-N87 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]
SGC-7901	IC₅₀	3.2 μM Compound: 4	Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay	[PMID: 39091011]

Molecular Weight

899.96

Formula

C₅₅H₇₀BNO₉

CAS No.

2763063-09-6

SMILES

O=C1C(C#N)=C[C@]2([C@]([H])(C1(C)C)CC[C@](C)(C2=CC3=O)[C@]4([C@]3([C@]5([C@@](C(OCCCCOC(C6=CC=C(C=C6)OCC7=CC=C(C=C7)B8OC(C)(C(C)(O8)C)C)=O)=O)(CC4)CCC(C)(C5)C)[H])[H])C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li N, et al., New CDDO Arylboronate Ester Derivatives with High Selectivity and Low Toxicity. J Med Chem. 2024 Aug 22;67(16):14329-14344. [Content Brief]