BR-3

By Targets:	ADC Antibody (1) ADC Payload (1) Akt (1) Androgen Receptor (1) Apoptosis (2) Biochemical Assay Reagents (1) EGFR (1) Farnesyl Transferase (1) Fluorescent Dye (1) Phosphodiesterase (PDE) (1) TNF Receptor (1) Topoisomerase (1)
By Research Areas:	Cancer (6) Inflammation/Immunology (2) Neurological Disease (1)
Click Chemistry:	Azide (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99487

Briobacept BR 3FC	ADC Antibody	Inflammation/Immunology
Briobacept (BR 3FC) is a recombinant glucoprotein, consists of 2 molecules from the BLyS receptor (BR3)and a Fc domain of human IgG1. Briobacept selectively targets to BLyS (BAFF), induces B cells apoptosis. Briobacept can be used in studies of rheumatoid arthritis (RA) .

HY-150401

Exatecan-amide-cyclopropanol	ADC Payload Topoisomerase	Cancer
Exatecan-amide-cyclopropanol (compound 1) is a anticancer agent. Exatecan-amide-cyclopropanol shows anti-proliferation activity against SK-BR-3 and U87 cells, with IC₅₀ values of 0.12 and 0.23 nM, respectively .

HY-W190881

N3-PEG11-CH2CH2Br	Biochemical Assay Reagents	Others
N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.

HY-10062

AZD3409 EBP-921	Akt Farnesyl Transferase	Cancer
AZD3409 is a prenyl inhibitor that exhibits inhibitory activity against both farnesyl transferase and geranylgeranyl transferase I. AZD3409 inhibits the growth of breast cancer cells, with IC₅₀s of 220 nM (MDA-MB-468), 180 nM (MDA-MB-361), and 290 nM (SK-Br-3). AZD3409 significantly reduces the activation level of AKT in breast cancer cell lines. AZD3409 induces G0/G1 phase arrest in MDA-MB-468 cells, causes G2/M phase arrest in MDA-MB-361 cells. AZD3409 can be used for the study of breast cancer .

HY-151615

DCI-Br-3	Fluorescent Dye	Neurological Disease
DCI-Br-3 is a rapid, highly sensitive, and selective probe to monitor thiols in the epileptic brain. (λ_ex=537 nm, λ_em=675 nm).DCI-Br-3 can effectively cross the blood-brain barrier (BBB) .

HY-P992424

NMB04	TNF Receptor	Inflammation/Immunology
NMB04 is a recombinant anti-Human CD257 (BAFF) (BLyS) antibody. NMB04 binds with specificity and high affinity to soluble and membrane-bound Blys, and blocks Blys binding to receptors TACI, BCMA, and *BR-3*. NMB04 can be used for the research of autoimmune diseases .

HY-N1265

Scutebata A	Others	Cancer
Scutebata A is a diterpenoid isolated from Scutellaria barbata that exhibits antitumor activity. Scutebata A is weakly cytotoxic against SK-BR-3 with an IC₅₀ value of 15.2 μM .

HY-173640

ID11916	Androgen Receptor Phosphodiesterase (PDE)	Cancer
ID11916 is an orally active androgen receptor (AR) antagonist and a phosphodiesterase 5 (PDE5) inhibitor. ID11916 blocks androgen binding to AR, nuclear translocation, and androgen-dependent transcriptional activity of AR, while increasing intracellular cGMP levels and activating PKG via inhibition. ID11916 shows potent anti-cancer effect in prostate cancer cell lines VCaP and 22Rv1 and in AR-positive breast cancer cell lines SK-BR-3 .

HY-P10393

ERα17p ERα (295-311)	Apoptosis	Cancer
ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D, and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathways. ERα17p inhibits proliferations of breast cancer cells, induces apoptosis, and inhibits tumor growth in mouse models ^[3].

HY-159519

EGFR/HER2-IN-16	Apoptosis EGFR	Cancer
EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC₅₀=6.15 nM) and HER-2 (IC₅₀=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research .

Cat. No.	Product Name	Type

HY-151615

DCI-Br-3	Fluorescent Dyes
DCI-Br-3 is a rapid, highly sensitive, and selective probe to monitor thiols in the epileptic brain. (λ_ex=537 nm, λ_em=675 nm).DCI-Br-3 can effectively cross the blood-brain barrier (BBB) .

Cat. No.	Product Name	Target	Research Area

HY-P10393

ERα17p ERα (295-311)	Apoptosis	Cancer
ERα17p (ERα 295-311) is the epitope of the CaM binding site on the estrogen receptor α (ER), which interacts with calmodulin (CaM) in a calcium-dependent manner. ERα17p regulates the migration of cancer cells MCF-7, SK-BR-3, T47D, and MDA-MB-231 through Rho/ROCK and PI3K/Akt signaling pathways. ERα17p inhibits proliferations of breast cancer cells, induces apoptosis, and inhibits tumor growth in mouse models ^[3].

Cat. No.	Product Name	Target	Research Area	Image

HY-P99487

Briobacept BR 3FC	ADC Antibody	Inflammation/Immunology
Briobacept (BR 3FC) is a recombinant glucoprotein, consists of 2 molecules from the BLyS receptor (BR3)and a Fc domain of human IgG1. Briobacept selectively targets to BLyS (BAFF), induces B cells apoptosis. Briobacept can be used in studies of rheumatoid arthritis (RA) .

HY-P992424

NMB04	TNF Receptor	Inflammation/Immunology
NMB04 is a recombinant anti-Human CD257 (BAFF) (BLyS) antibody. NMB04 binds with specificity and high affinity to soluble and membrane-bound Blys, and blocks Blys binding to receptors TACI, BCMA, and *BR-3*. NMB04 can be used for the research of autoimmune diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1265

Scutebata A	Terpenoids Labiatae Sesquiterpenes Derris robusta Diterpenoids Plants Source Classification	Others
Scutebata A is a diterpenoid isolated from Scutellaria barbata that exhibits antitumor activity. Scutebata A is weakly cytotoxic against SK-BR-3 with an IC₅₀ value of 15.2 μM .

Species:	Human (8) Rhesus Macaque (2) Mouse (1) Rat (2) Cynomolgus (2)
Tag:	His (5) Tag Free (1) Avi (2) Flag (1) Fc (8)
Source:	HEK293 (12) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P703872

	BAFFR/TNFRSF13C Protein, Human (HEK293, His, Fc) rHuBAFF-R; CD268; TNFRSF13C; BR3	Human	HEK293
	BAFFR/TNFRSF13C Protein, a B-cell receptor, specifically recognizes TNFSF13B/TALL1/BAFF/BLyS, playing a crucial role in promoting the survival of mature B-cells and enhancing the B-cell response, contributing to a healthy immune system. BAFFR/TNFRSF13C Protein, Human (HEK293, His, Fc) is the recombinant human-derived BAFFR/TNFRSF13C protein, expressed by HEK293, with C-His and N-hFc labeled tag.

HY-P703873

	BAFFR/TNFRSF13C Protein, Human (Biotinylated, HEK293, hFc, Avi) rHuBAFF-R; CD268; TNFRSF13C; BR3	Human	HEK293
	BAFFR/TNFRSF13C Protein, a B-cell receptor, specifically recognizes TNFSF13B/TALL1/BAFF/BLyS, playing a crucial role in promoting the survival of mature B-cells and enhancing the B-cell response, contributing to a healthy immune system. BAFFR/TNFRSF13C Protein, Human (Biotinylated, HEK293, hFc, Avi) is the recombinant human-derived BAFFR/TNFRSF13C protein, expressed by HEK293, with Avi and C-hFc labeled tag.

HY-P704304

	BAFFR/TNFRSF13C Protein, Human (HEK293, Llama Fc) Tumor necrosis factor receptor superfamily member 13C; BAFF-R; CD268; TNFRSF13C; BR3	Human	HEK293
	BAFFR/TNFRSF13C Protein, a B-cell receptor, specifically recognizes TNFSF13B/TALL1/BAFF/BLyS, playing a crucial role in promoting the survival of mature B-cells and enhancing the B-cell response, contributing to a healthy immune system. BAFFR/TNFRSF13C Protein, Human (HEK293, Llama Fc) is the recombinant human-derived BAFFR/TNFRSF13C protein, expressed by HEK293, with C-Llama Fc labeled tag.

HY-P76744

	BAFFR/TNFRSF13C Protein, Rat (HEK293, Fc) Tumor necrosis factor receptor superfamily member 13C; BAFF-R; CD268; TNFRSF13C; BR3	Rat	HEK293
	BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation. BAFFR/TNFRSF13C Protein, Rat (HEK293, Fc) is a recombinant protein with a C-Terminal hFC label, It consists of 62 amino acids (S10-A71) and is produced in HEK293 cells.

HY-P704248

	BAFFR/TNFRSF13C Protein, Human (HEK293, hFc) Tumor necrosis factor receptor superfamily member 13C; BAFF-R; CD268; TNFRSF13C; BR3	Human	HEK293
	BAFFR/TNFRSF13C Protein, a B-cell receptor, specifically recognizes TNFSF13B/TALL1/BAFF/BLyS, playing a crucial role in promoting the survival of mature B-cells and enhancing the B-cell response, contributing to a healthy immune system. BAFFR/TNFRSF13C Protein, Human (HEK293, hFc) is the recombinant human-derived BAFFR/TNFRSF13C protein, expressed by HEK293, with C-hFc labeled tag.

HY-P78065

	BAFFR/TNFRSF13C Protein, Human (Biotinylated, HEK293, His-Avi) CD268; BAFFR; BR3; TNFRSF13C; BROMIX; CVID4; prolixin	Human	HEK293
	BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation. BAFFR/TNFRSF13C Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant protein with a C-Terminal Avi label and a C-Terminal His label, produced in HEK293 cells.

HY-P77570

	BAFFR/TNFRSF13C Protein, Cynomolgus/Rhesus Macaque (HEK293, His) CD268; BAFFR; BR3; TNFRSF13C; BROMIX; CVID4; prolixin	Rhesus Macaque;Cynomolgus	HEK293
	BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation. BAFFR/TNFRSF13C Protein, Cynomolgus/Rhesus Macaque (HEK293, His) is a recombinant protein with a C-Terminal His label.

HY-P703951

	BAFFR/TNFRSF13C Protein, Cynomolgus/Rhesus Macaque (HEK293, hFc) CD268; BAFFR; BR3; TNFRSF13C; BROMIX; CVID4; prolixin	Rhesus Macaque;Cynomolgus	HEK293
	BAFFR/TNFRSF13C Protein, Cynomolgus/Rhesus Macaque (HEK293, hFc) is the recombinant cynomolgus-derived BAFFR/TNFRSF13C protein, expressed by HEK293, with C-hFc tag.

HY-P700453

	BAFFR/TNFRSF13C Protein, Human (HEK293, hFc-Flag) Tumor necrosis factor receptor superfamily member 13C; BAFF-R; CD268; TNFRSF13C; BR3	Human	HEK293
	BAFFR/TNFRSF13C Protein, a B-cell receptor, specifically recognizes TNFSF13B/TALL1/BAFF/BLyS, playing a crucial role in promoting the survival of mature B-cells and enhancing the B-cell response, contributing to a healthy immune system. BAFFR/TNFRSF13C Protein, Human (HEK293, hFc-Flag) is the recombinant human-derived BAFFR/TNFRSF13C protein, expressed by HEK293 , with C-hFc, C-Flag labeled tag.

HY-P72764

	BAFFR/TNFRSF13C Protein, Human (HEK293, His) Tumor necrosis factor receptor superfamily member 13C; BAFF-R; CD268; TNFRSF13C; BR3	Human	HEK293
	BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation. BAFFR/TNFRSF13C Protein, Human (HEK293, His) is a recombinant protein with a C-Terminal His label, produced in HEK293 cells.

HY-P76745

	BAFFR/TNFRSF13C Protein, Rat (HEK293, His) Tumor necrosis factor receptor superfamily member 13C; BAFF-R; CD268; TNFRSF13C; BR3	Rat	HEK293
	BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation. BAFFR/TNFRSF13C Protein, Rat (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 62 amino acids (S10-A71) and is produced in HEK293 cells.

HY-P7646

	BAFFR/TNFRSF13C Protein, Mouse (HEK293, Fc) rMuBAFFR/TNFRSF13C, C-Fc; BAFF R; BAFFR; BR3; CD268; TNFRSF13C	Mouse	HEK293
	BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation. BAFFR/TNFRSF13C Protein, Mouse (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 62 amino acids (S10-A71) and is produced in HEK293 cells.

HY-P7130

	BAFFR/TNFRSF13C Protein, Human rHuBAFF-R; CD268; TNFRSF13C; BR3	Human	E. coli
	BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is a potent costimulator of both B and T cell activation. BAFFR/TNFRSF13C Protein, Human is a recombinant protein produced in E. coli.

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Cat. No.	Product Name		Classification

HY-W190881

N3-PEG11-CH2CH2Br		Azide
N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.

HY-159519

EGFR/HER2-IN-16		Azide
EGFR/HER2-IN-16 (compound 12K) is an effective dual-target inhibitor of EGFR (IC₅₀=6.15 nM) and HER-2 (IC₅₀=9.78 nM) with anti-tumor activity. EGFR/HER2-IN-16 can inhibit the migration of SK-BR-3 cells, arrest the cell cycle in the G0/G1 phase, and induce apoptosis. EGFR/HER2-IN-16 exhibits good anti-proliferative activity against tumor cell models and has little damage to healthy cells. EGFR/HER2-IN-16 can be used in breast cancer research .

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