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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
BRD4-IN-7
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "BRD4-IN-7" in MCE Product Catalog:
Cat. No.: HY-160671
CAS No.: 1446232-98-9
Target:
Research Areas:
BRD4-IN-7 (compound 120) is a BRD4 inhibitor(extracted from patent CN107721975A).
Cat. No.: HY-W854844B
Research Areas:
JP-2-196 hydrochloride is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 hydrochloride also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 hydrochloride induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride has potential for cancer research (such as prostate cancer and leukemia) .
Cat. No.: HY-183077
Research Areas:
BRD4 degrader-7 (Compound ZZ1) is a CTLH-dependent BRD4 degrader and c-Glue with a DC50 of 489 nM. BRD4 degrader-7 converts to a sulfinic acid derivative inside cells, interacts with the basic pocket of YPEL5, mediates the bridging of BRD4 BD1 to the YPEL5 subunit of the CTLH E3 ubiquitin ligase, and thereby promotes the formation of a ternary complex. BRD4 degrader-7 can be used in research on Ewing's sarcoma and leukemia .
Cat. No.: HY-W854844
CAS No.: 2913587-30-9
Research Areas:
JP-2-196 is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 has potential for cancer research (such as prostate cancer and leukemia) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
