BRD4 degrader-7
BRD4 degrader-7 (Compound ZZ1) is a CTLH-dependent BRD4 degrader and c-Glue with a DC50 of 489 nM. BRD4 degrader-7 converts to a sulfinic acid derivative inside cells, interacts with the basic pocket of YPEL5, mediates the bridging of BRD4 BD1 to the YPEL5 subunit of the CTLH E3 ubiquitin ligase, and thereby promotes the formation of a ternary complex. BRD4 degrader-7 can be used in research on Ewing's sarcoma and leukemia.
For research use only. We do not sell to patients.
- Formula: C30H29ClFN5O5S2
- Molecular Weight:658.16
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRD4 489 nM (DC50) |
CTLH |
BRD4 degrader-7 (ZZ1) (10-10000 nM; 5 h) potently induces proteasome-dependent degradation of BRD4 in Jurkat cells via a non-CRL E3 ligase pathway, with a DC50 of 502 nM[1].
BRD4 degrader-7 (10-10000 nM; 5 h) induces BRD4 degradation in Jurkat cells, with a DC50 of 489 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 658.16
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Formula C30H29ClFN5O5S2
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SMILES
ClC1=CC(C(NC(C=C2)=CC=C2C3=N[C@@H](CC(OC(C)(C)C)=O)C4=NN=C(C)N4C5=C3C(C)=C(C)S5)=O)=CC=C1S(F)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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