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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
BSO
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "BSO" in MCE Product Catalog:
37
37 Publications Verification
Synonyms: Buthionine sulfoximine; BSO
Target:
Research Areas:
DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
37
37 Publications Verification
Cat. No.: HY-106376B
Purity: 99.09%
Synonyms: Buthionine sulfoximine hydrochloride; BSO hydrochloride
Target:
Research Areas:
DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
21
21 Cited Publications
Synonyms: L-Buthionine sulfoximine; L-BSO
Target:
Research Areas:
L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
21
21 Cited Publications
Cat. No.: HY-106376C
Purity: ≥98.0%
Synonyms: L-Buthionine sulfoximine hydrochloride; L-BSO hydrochloride
Target:
Research Areas:
L-Buthionine-(S,R)-sulfoximine hydrochloride is a cell-permeable, potent, fast acting, orally active and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively .
1
Cat. No.: HY-179561
CAS No.: 894430-68-3
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Research Areas:
ACS14 is a derivative of Aspirin (HY-14654). ACS14 reduces Buthionine Sulfoximine (BSO) (HY-106376)-induced hypertension, plasma levels of thromboxane B2, 8-isoprostane, and insulin in rats, while GSH remained in the control range. ACS14 can be used for hypertension research .
Cat. No.: HY-162886
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Research Areas:
BSO-07 is a ROS/JNK activator with significant anticancer effects, having an IC50 value of 24.81 μM against human breast cancer (BC) cells. BSO-07 induces apoptosis (Apoptosis) and paraptosis by activating JNK and increasing ROS levels, including enhancing the expression of apoptosis-associated proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, while decreasing the levels of anti-apoptotic proteins like Bcl-2, Bcl-xL, and Survivin. BSO-07 holds promise for research in the field of breast cancer .
Cat. No.: HY-106376BR
Synonyms: Buthionine sulfoximine hydrochloride (Standard); BSO hydrochloride (Standard)
Target:
Research Areas:
DL-Buthionine-(S,R)-sulfoximine (hydrochloride) (Standard) is the analytical standard of DL-Buthionine-(S,R)-sulfoximine (hydrochloride). This product is intended for research and analytical applications. DL-Buthionine-(S,R)-sulfoximine hydrochloride (Buthionine sulfoximine hydrochloride) is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
Cat. No.: HY-106376R
CAS No.: 5072-26-4
Synonyms: Buthionine sulfoximine (Standard); BSO (Standard)
Target:
Research Areas:
DL-Buthionine-(S,R)-sulfoximine (Standard) is the analytical standard of DL-Buthionine-(S,R)-sulfoximine. This product is intended for research and analytical applications. DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis.
Cat. No.: HY-158740
CAS No.: 2644636-20-2
Target:
Research Areas:
1(R)-(Trifluoromethyl)oleyl alcohol (compound (R)-24) is a trifluoromethyl alcohol derivative of Oleic acid (HY-N1446) with activity in multiple models of Friedreich ataxia (FRDA). 1(R)-(Trifluoromethyl)oleyl alcohol inhibits ferroptosis induced by Erastin (HY-15763) and decreases lipid peroxidation in NBT human myoblasts with frataxin (FXN) siRNA knockdown. 1(R)-(Trifluoromethyl)oleyl alcohol at 40 μM increases survival to 95% in a model of FRDA where a significant percentage of cell death is caused by FAC (HY-B1645) and BSO (HY-106376) .
Cat. No.: HY-184361
CAS No.: 143202-57-7
Synonyms: Ethyl 20:4BSO
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Juniperonic acid ethyl ester (Ethyl 20:4BSO) is an orally active non-methylene-interrupted ω-3 polyunsaturated fatty acid ethyl ester. Juniperonic acid ethyl ester exists in Platycladus orientalis seed oil. Juniperonic acid ethyl ester reduces the ratio of 20:3n-9 to arachidonic acid in hepatic phosphatidylcholine of rats with essential fatty acid deficiency. Juniperonic acid ethyl ester is applicable to the research of hypertension and hepatic reperfusion injury .
Cat. No.: HY-106376AR
CAS No.: 83730-53-4
Synonyms: L-Buthionine sulfoximine (Standard); L-BSO (Standard)
Target:
Research Areas:
L-Buthionine-(S,R)-sulfoximine (Standard) is the analytical standard of L-Buthionine-(S,R)-sulfoximine (HY-106376A). This product is intended for research and analytical applications. L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
Cat. No.: HY-183406
CAS No.: 102616-62-6
Research Areas:
AS15 is a PDIA1 inhibitor with an IC50 value of 300 nM. AS15 interacts with the active-site cysteine of PDIA1, and this process is independent of the substrate-binding domain of PDIA1. AS15 acts as a synergistic cell growth inhibitor with buthionine sulfoximine (BSO) (HY-106376), a glutathione synthesis inhibitor. AS15 can be used in the research of glioblastoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
