L-Buthionine-(S,R)-sulfoximine (Standard)
L-Buthionine-(S,R)-sulfoximine (Standard) is the analytical standard of L-Buthionine-(S,R)-sulfoximine (HY-106376A). This product is intended for research and analytical applications. L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
For research use only. We do not sell to patients.
- Purity : 98%
- CAS No.: 83730-53-4
- Formula: C8H18N2O3S
- Molecular Weight:222.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-106376A
L-Buthionine-(S,R)-sulfoximine -
HY-106376
DL-Buthionine-(S,R)-sulfoximine -
HY-100218A
RSL3 -
HY-100579
Ferrostatin-1 -
HY-15763
Erastin -
HY-12726
Liproxstatin-1 -
HY-136057
iFSP1 -
HY-114481
Imidazole ketone erastin -
HY-103087
FIN56 -
HY-B0165A
Pravastatin sodium -
HY-19424
Hemin -
HY-D1301
BODIPY 581/591 C11
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 83730-53-4
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Molecular Weight 222.31
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Formula C8H18N2O3S
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SMILES
N[C@H](C(O)=O)CCS(CCCC)(=O)=N
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Synonyms
L-Buthionine sulfoximine (Standard); L-BSO (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Fruehauf JP, et al. Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase. Pigment Cell Res. 1997 Aug;10(4):236-49. [Content Brief]
[2]. Reliene R, et al. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis. 2006 Feb;27(2):240-4. [Content Brief]
[3]. Satoru Nishizawa, et al. Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors. Oncol Lett. 2018 Jun;15(6):8735-8743. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Buthionine-(S,R)-sulfoximine (Standard) Related Classifications
HY-106376AR Related Classifications
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