102616-62-6
102616-62-6
Chemical Structure
AS15
- CAS No.: 102616-62-6
- Formula:C20H23NO6
- Molecular Weight:373.40
InChIKey: POUGOEFZYGQTHG-UHFFFAOYSA-N
SMILES: OC1=C(C(N2CCOCC2)C3=CC=C(C(OC)=C3)OC)C=C4OCOC4=C1
Biological Activity: AS15 is a PDIA1 inhibitor with an IC50 value of 300 nM. AS15 interacts with the active-site cysteine of PDIA1, and this process is independent of the substrate-binding domain of PDIA1. AS15 acts as a synergistic cell growth inhibitor with buthionine sulfoximine (BSO) (HY-106376), a glutathione synthesis inhibitor. AS15 can be used in the research of glioblastoma[1].
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AS15 | AS15 is a PDIA1 inhibitor with an IC50 value of 300 nM. AS15 interacts with the active-site cysteine of PDIA1, and this process is independent of the substrate-binding domain of PDIA1. AS15 acts as a synergistic cell growth inhibitor with buthionine sulfoximine (BSO) (HY-106376), a glutathione synthesis inhibitor. AS15 can be used in the research of glioblastoma. | |||||||||||||||||||||
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References
Keywords
