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23

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17

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356

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62

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-142979
    DSPE-PEG 2000
    10+ Cited Publications

    (C2H4O)nC42H82NO10P

    		 Liposome Others
    DSPE-PEG 2000 is a PEG polymer containing DSPE and amine end groups. DSPE-PEG 2000 can be used to form micelles as nanoparticles for drug delivery [2].
    DSPE-PEG 2000
  • HY-101180
    C2 Ceramide
    2 Publications Verification

    Ceramide 2

    		 Phosphatase Mitochondrial Metabolism Apoptosis Autophagy Metabolic Disease Endocrinology
    C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss [2] .
    C2 Ceramide
  • HY-W040165
    Amino-PEG3-C2-acid

    		ADC Linker PROTAC Linkers Cancer
    Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Amino-PEG3-C2-acid
  • HY-W040168
    Amino-PEG2-C2-acid

    		ADC Linker PROTAC Linkers Cancer
    Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Amino-PEG2-C2-acid
  • HY-N1517
    Ganoderic acid C2

    		Aldose Reductase Inflammation/Immunology Cancer
    Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 is the inhibitor for aldose reductase with an IC50 of 43.8 µM [2].
    Ganoderic acid C2
  • HY-N6980
    Licorice glycoside C2
    1 Publications Verification

    		 Others Others
    Licorice glycoside C2 is an acylated flavonoid glycoside found in the underground part of Glycyrrhiza uralensis .
    Licorice glycoside C2
  • HY-113697
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
    2 Publications Verification

    Mal-PEG2-AZD

    		 PROTAC Linkers Cancer
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (Mal-PEG2-AZD) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD
  • HY-W777012
    Acridinium C2 NHS ester

    		Fluorescent Dye
    Acridinium C2 NHS ester is a chemiluminescent label that is active for the development of protein and nucleic acid probes. Acridinium C2 NHS ester can be used in bioanalysis and diagnostics to provide highly sensitive detection solutions. Acridinium C2 NHS ester is widely used in medical research, especially in the monitoring and analysis of biomolecules.
    Acridinium C2 NHS ester
  • HY-140127
    Azide-C2-SS-C2-biotin

    		ADC Linker Cancer
    Azide-C2-SS-C2-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azide-C2-SS-C2-biotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-C2-SS-C2-biotin
  • HY-N11857
    Gentamicin C2

    		Antibiotic Bacterial Infection
    Gentamicin C2 is an aminoglycoside antibiotic with broad-spectrum bactericidal activity, selectively binding to the bacterial 16S rRNA A-site. Gentamicin C2 interferes with protein synthesis initiation and translation fidelity to exert bactericidal effects. Gentamicin C2 can be used for the research of bacterial infections [2] .
    Gentamicin C2
  • HY-P99163
    Tilavonemab

    ABBV-8E12; C2N-8E12

    		 Tau Protein Neurological Disease
    Tilavonemab (ABBV-8E12) is a humanized anti-tau monoclonal antibody that binds to amino acids 25-30 near the N-terminus of the tau protein. Tilavonemab can block the ability of human and mouse neurons to uptake tau aggregates. Tilavonemab can be used for research on Alzheimer’s disease and other tauopathies [2] .
    Tilavonemab
  • HY-148080
    Indole-C2-amide-C2-NH2

    		ADC Linker Others
    Indole-C2-amide-C2-NH2 is a potent linker .
    Indole-C2-amide-C2-NH2
  • HY-130713
    Thalidomide-C2-amido-C2-COOH

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-C2-amido-C2-COOH contains a CRBN ligand and a linker for recruiting E3 ubiquitin ligases. Thalidomide-C2-amido-C2-COOH can be used to design and synthesize PROTAC CDK2/9 Degrader-1 (HY-130709). PROTAC CDK2/9 Degrader-1 is applicable to prostate cancer-related research .
    Thalidomide-C2-amido-C2-COOH
  • HY-115384
    Amino-PEG5-C2-acid

    		ADC Linker PROTAC Linkers Cancer
    Amino-PEG5-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG5-C2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Amino-PEG5-C2-acid
  • HY-134682
    Fmoc-NH-PEG5-C2-NH2

    		PROTAC Linkers Cancer
    Fmoc-NH-PEG5-C2-NH2 is a PEG-based PROTAC linker. Fmoc-NH-PEG5-C2-NH2 can be used in the synthesis of PROTACs .
    Fmoc-NH-PEG5-C2-NH2
  • HY-W590664
    C2 Dihydroceramide

    		Endogenous Metabolite Cardiovascular Disease
    C2 Dihydroceramide is a derivative of C2 Ceramide (HY-101180). C2 Dihydroceramide enhances the ABCA1-mediated cholesterol efflux to apolipoprotein A-I (apoA-I) without causing cytotoxicity .
    C2 Dihydroceramide
  • HY-130436
    Acid-C2-PEG4-C2-NHS ester

    		PROTAC Linkers Cancer
    Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
    Acid-C2-PEG4-C2-NHS ester
  • HY-N7521
    Procyanidin C2

    Procyanidine C2

    		 Acetyl-CoA Carboxylase Fatty Acid Synthase (FASN) Stearoyl-CoA Desaturase (SCD) PPAR AMPK mTOR JNK Inflammation/Immunology
    Procyanidin C2 (Procyanidine C2) is a lipid metabolism regulator and antioxidant with free radical scavenging activity. Procyanidin C2 down-regulates ACC, SREBP-1c, FAS, SCD-1 and PPARγ. Procyanidin C2 increases the level of phosphorylated AMPKα and inhibits the level of phosphorylated mTOR. Procyanidin C2 reduces lipid accumulation, alleviates oxidative stress, enhances fatty acid oxidation and improves mitochondrial function. Procyanidin C2 can be used in the research of non-alcoholic fatty liver disease .
    Procyanidin C2
  • HY-126830
    Antifolate C2

    		Antifolate Apoptosis Cancer
    Antifolate C2 is an anti-folate compound that has inhibitory effects on the proliferation of non-squamous non-small cell lung cancer (NS-NSCLC). Antifolate C2 achieves tumor selectivity by targeting proton-coupled folate transporter (PCFT), which is more selective to PCFT than the commonly used anti-folate drug Pemetrexed (HY-10820). Antifolate C2 blocks the biosynthesis of deoxypurine nucleotides by inhibiting glycinamide ribonucleotide formyltransferase (GARFTase), ultimately inhibiting the proliferation of tumor cells. Antifolate C2 can be used in studies of NS-NSCLC, especially in patients who do not respond well to Pemetrexed .
    Antifolate C2
  • HY-130155
    AMPK activator C2

    		AMPK Neurological Disease
    AMPK activator C2 is a potent allosteric AMPK activator that is promising for research of epilepsy and convulsions .
    AMPK activator C2
  • HY-156207
    C2 Adamantanyl globotriaosylceramide (d18:1/2:0)

    AdaGb3; Adamantyl Gb3; C2 Adamantanyl Ceramide Trihexoside (d18:1/2:0)

    		 P-glycoprotein Cancer
    C2 Adamantanyl globotriaosylceramide (d18:1/2:0) (AdaGb3), a water-soluble globotriaosylceramide analog, is a bioactive sphingolipid. C2 Adamantanyl globotriaosylceramide (d18:1/2:0) reverses MDR1-MDCK cell drug resistance. C2 Adamantanyl globotriaosylceramide (d18:1/2:0) has high affinity for verotoxin (VT) [2].
    C2 Adamantanyl globotriaosylceramide (d18:1/2:0)
  • HY-176518
    ssPalmE-P4-C2

    		Liposome Ser/Thr Protease Infection Neurological Disease Metabolic Disease
    ssPalmE-P4-C2 is a SS-cleavable and pH-sensitive lipid-like material (ssPalm) with a vitamin E‑scaffold. ssPalmE-P4-C2 improves gene knockdown activity against FVII with an ED50 of 0.5 mg/kg. ssPalmE-P4-C2 can be used to synthesize lipid nanoparticles (LNPs) for delivering siRNA to the hepatocyte. ssPalmE-P4-C2 can be used for the RNA therapies for dyslipidemia, hepatitis B/C infections and transthyretin amyloidosis research .
    ssPalmE-P4-C2
  • HY-148484
    Pomalidomide-5'-PEG5-C2-COOH

    		Drug Derivative Others
    Pomalidomide-5'-PEG5-C2-COOH is an active compound. Pomalidomide-5'-PEG5-C2-COOH can be used for the research of various biochemical .
    Pomalidomide-5'-PEG5-C2-COOH
  • HY-156304
    Coumarin-C2-TCO

    		Fluorescent Dye Others
    Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
    Coumarin-C2-TCO
  • HY-124273
    C2 L-threo Ceramide (d18:1/2:0)

    L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0); N-acetyl-L-threo-Sphingosine

    		 Endogenous Metabolite Cardiovascular Disease
    C2 L-threo Ceramide (d18:1/2:0) (L-threo Cer(d18:1/2:0); L-threo Ceramide (d18:1/2:0)) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide. C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.
    C2 L-threo Ceramide (d18:1/2:0)
  • HY-N1517R
    Ganoderic acid C2 (Standard)

    		Aldose Reductase Reference Standards Inflammation/Immunology Cancer
    Ganoderic acid C2 (Standard) is the analytical standard of Ganoderic acid C2. This product is intended for research and analytical applications. Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses the potential anti-tumor bioactivity, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 is the inhibitor for aldose reductase with an IC50 of 43.8 µM [2].
    Ganoderic acid C2 (Standard)
  • HY-N1517A
    (Rac)-Ganoderic acid C2

    		Aldose Reductase Cancer
    (Rac)-Ganoderic acid C2 is the racemate of Ganoderic acid C2 (HY-N1517). Ganoderic acid C2 is a bioactive triterpenoid in Ganoderma lucidum. Ganoderic acid C2 possesses anti-tumor, antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (RLAR) with an IC50 of 3.8 µM[ [2].
    (Rac)-Ganoderic acid C2
  • HY-138083
    Parvodicin C2

    		Bacterial Antibiotic Infection
    Parvodicin C2 is a glycopeptide antibiotic that can be isolated from parvosata. Parvodicin C2 has antibacterial activity .
    Parvodicin C2
  • HY-N14459
    Pluracidomycin C2

    		Antibiotic Bacterial Infection
    Pluracidomycin C2 is a carbapenem antibiotic. Pluracidomycin C2 has anti-Gram-positive bacteria and Gram-negative bacteria activities .
    Pluracidomycin C2
  • HY-N12297
    Ciwujianoside C2

    		Lipase Others
    Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro .
    Ciwujianoside C2
  • HY-N15704
    Cassiaside C2

    		Histamine Receptor Inflammation/Immunology
    Cassiaside C2 is a naphthopyrone with a strong antiallergic activity. Cassiaside C2 inhibits the histamine release from rat peritoneal exudate mast cells induced by antigen-antibody reaction [2].
    Cassiaside C2
  • HY-N14431
    Salfredin C2

    		Aldose Reductase Metabolic Disease
    Salfredin C2 is an aldose reductase inhibitor .
    Salfredin C2
  • HY-N14844
    Napyradiomycin C2

    		Antibiotic Bacterial Infection
    Napyradiomycin C2 is an antibiotic with anti-Gram-positive bacteria and mycobacterial activity .
    Napyradiomycin C2
  • HY-165072
    C2 3'-Sulfo galactosylceramide (d18:1/2:0)

    C2 Sulfatide; N-Acetyl sulfatide

    		 Biochemical Assay Reagents Others
    C2 3'-Sulfo galactosylceramide (d18:1/2:0) (C2 Sulfatide) is one of the sulfatide class of glycolipids. C2 3'-Sulfo galactosylceramide (d18:1/2:0) can be used in the quantification of lysosulfatides in mouse brain tissue and plasma .
    C2 3'-Sulfo galactosylceramide (d18:1/2:0)
  • HY-W590667
    C2 Ceramide-1-phosphate

    		Biochemical Assay Reagents Others
    C2 Ceramide-1-phosphate is a phospholipid. Phospholipids have good biocompatibility and significant amphiphilic characteristics, making them the main and suitable dosage form or excipient in drug formulations, thereby achieving better therapeutic effects. C2 Ceramide-1-phosphatecan be used in drug delivery research .
    C2 Ceramide-1-phosphate
  • HY-N14705
    2-Hydroxygentamicin C2

    		Antibiotic Bacterial Infection
    2-Hydroxygentamicin C2 is an antibiotic of the gentamicin group with anti-Gram-positive and negative bacteria activity .
    2-Hydroxygentamicin C2
  • HY-N14104
    Cinatrin C2

    		Phospholipase Others
    Cinatrin C2 is a phospholipase A2 (PLA2) inhibitor with an IC50 of 800 μM and can be extracted from Circinotrichum falcatisporum RF-641 [2].
    Cinatrin C2
  • HY-RS01738
    C2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    C2 Human Pre-designed siRNA Set A contains three designed siRNAs for C2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    C2 Human Pre-designed siRNA Set A
    C2 Human Pre-designed siRNA Set A
  • HY-RS17030
    C2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    C2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for C2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    C2 Mouse Pre-designed siRNA Set A
    C2 Mouse Pre-designed siRNA Set A
  • HY-N14709
    Kibdelin C2

    		Bacterial Infection
    Kibdelin C2 is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .
    Kibdelin C2
  • HY-N6910
    Pseudolaric Acid C2

    		Others Metabolic Disease
    Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats [2].
    Pseudolaric Acid C2
  • HY-169480
    Lipid C2

    		Liposome Infection Cancer
    Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNP) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3 +CD8 + central and CD3 +CD8 + effector memory T cells and decrease the percentage of CD3 + T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model .
    Lipid C2
  • HY-166226
    C2 Sphingomyelin (d18:1/2:0)

    		Biochemical Assay Reagents Metabolic Disease
    C2 Sphingomyelin (d18:1/2:0) is an ester product.
    C2 Sphingomyelin (d18:1/2:0)
  • HY-135868
    Mito-apocynin (C2)

    		Mitochondrial Metabolism Neurological Disease
    Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP + cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect .
    Mito-apocynin (C2)
  • HY-N15125
    1-Deamino-1-hydroxygentamicin C2

    Antibiotic SU-1

    		 Antibiotic Bacterial Infection
    1-Deamino-1-hydroxygentamicin C2 (Antibiotic SU-1) is an aminoglycotone antibiotic. 1-Deamino-1-hydroxygentamicin C2 has the activity against Gram-positive and Gram-negative bacteria .
    1-Deamino-1-hydroxygentamicin C2
  • HY-116877
    C2 Ceramide (d14:1/2:0)

    		COX Cancer
    C2 Ceramide (d14:1/2:0) is a composition for diagnosing diseases associated with cyclooxygenase 2 (COX2) overexpression. C2 Ceramide (d14:1/2:0) exhibits a strong binding activity to COX2 protein (extracted from patent WO2019235824A1).
    C2 Ceramide (d14:1/2:0)
  • HY-131992
    N-Acetylpsychosine

    C2 Galactosylceramide (d18:1/2:0)

    		 Apoptosis Inflammation/Immunology
    N-Acetylpsychosine (C2 Galactosylceramide (d18:1/2:0)), α-galactosylated C2-ceramide, has immunostimulatory activity. N-Acetylpsychosine can be a useful tool to investigate the mechanism of apoptosis and the immune reponses induced by dendritic cells (DCs) .
    N-Acetylpsychosine
  • HY-180121
    tBu-MTX-CO-NH-C2-O-C2-N3

    		Drug Intermediate Others
    tBu-MTX-CO-NH-C2-O-C2-N3 (Compound 4a) is an azide compound, which can be used as a drug intermediate for the construction of chemical inducers of dimerisation.
    tBu-MTX-CO-NH-C2-O-C2-N3
  • HY-126673
    Mal-C2-Gly3-EDA

    		ADC Linker Cancer
    Mal-C2-Gly3-EDA is a cleavable ADC linker containing a Maleimide group. Mal-C2-Gly3-EDA is used for making antibody-drug conjugate.
    Mal-C2-Gly3-EDA
  • HY-103708
    Nezukone

    C2-deoxyhinokitiol; 4-Isopropyltropone

    		 Drug Derivative Others
    Nezukone is a derivative of hinokitiol. Hinokitiol can restore iron transports, however, Nezukone cannot bind or transport iron.
    Nezukone

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