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IBS008738 

Cat. No.: HY-112821
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IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model.

For research use only. We do not sell to patients.

IBS008738 Chemical Structure

IBS008738 Chemical Structure

CAS No. : 385425-03-6

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Description

IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model[1][2].

IC50 & Target

TAZ[1]

In Vitro

IBS008738 (0, 24, 48, 72 h) enhances TAZ expression, with a peak at 24 h[1].
IBS008738 (10 μM; 0, 24, 72 h) enhances mRNAs of myogenic markers but not of myofusion markers[1].
IBS008738 (10 μM; 24h) enhances mRNAs of IL-10 in C2C12 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: C2C12 cells
Concentration:
Incubation Time: Treated for 0, 24, 48, 72 h under differentiation conditions after 24 h under growth conditions.
Result: Enhanced TAZ expression, with a peak at 24 h.

RT-PCR[1]

Cell Line: C2C12 cells
Concentration: 10 μM
Incubation Time: 0, 24, 72 h under differentiation
Result: Enhanced mRNAs of myogenic markers but not of myofusion markers.
In Vivo

IBS008738 (3 nmol) facilitates muscle repair in Cardiotoxin-injected muscles[1].
IBS008738 (30 μM, 100 μL) prevents Dexamethasone-induced muscle atrophy[1].
IBS008738 (100-μL volume of 30 μM; intramuscular injection; immediately and on day 2 after TBI) diminishes the expression of TNF α and IL-6 but increases that of IL-10 mRNAs in muscles of traumatic brain injury (TBI)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old female BALB/cByJ mice[1]
Dosage: 3 nmol (0.3 μL of 10 mM IBS008738 was diluted in 100 μL of PBS)
Administration: Injected into the tibialis anterior (TA) muscle of mice under anesthesia.
Result: Facilitated muscle repair in Cardiotoxin-injected muscles.
Animal Model: Six-week-old female BALB/cByJ mice[1]
Dosage: 30 μM (100 μL)
Administration: Injected into the tibialis anterior (TA) and gastrocnemius (GM) muscles on days 9, 11, and 13.
Result: Prevented Dexamethasone-induced muscle atrophy.
Molecular Weight

374.44

Formula

C₂₂H₂₂N₄O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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IBS008738
Cat. No.:
HY-112821
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