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IBS008738 

Cat. No.: HY-112821 Purity: 98.22%
COA Handling Instructions

IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model.

For research use only. We do not sell to patients.

IBS008738 Chemical Structure

IBS008738 Chemical Structure

CAS No. : 385425-03-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 286 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 286 In-stock
Solid
5 mg USD 260 In-stock
10 mg USD 400 In-stock
25 mg USD 750 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

IBS008738 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

IBS008738 is a potent TAZ activator. IBS008738 stabilizes TAZ, increases the unphosphorylated TAZ level, enhances the association of MyoD with the myogenin promoter, upregulates MyoD-dependent gene transcription, and competes with myostatin in C2C12 cells. IBS008738 enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model[1][2].

IC50 & Target

TAZ[1]
In Vitro

IBS008738 (0, 24, 48, 72 h) enhances TAZ expression, with a peak at 24 h[1].
IBS008738 (10 μM; 0, 24, 72 h) enhances mRNAs of myogenic markers but not of myofusion markers[1].
IBS008738 (10 μM; 24h) enhances mRNAs of IL-10 in C2C12 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IBS008738 Related Antibodies

Western Blot Analysis[1]

Cell Line: C2C12 cells
Concentration:
Incubation Time: Treated for 0, 24, 48, 72 h under differentiation conditions after 24 h under growth conditions.
Result: Enhanced TAZ expression, with a peak at 24 h.

RT-PCR[1]

Cell Line: C2C12 cells
Concentration: 10 μM
Incubation Time: 0, 24, 72 h under differentiation
Result: Enhanced mRNAs of myogenic markers but not of myofusion markers.
In Vivo

IBS008738 (3 nmol) facilitates muscle repair in Cardiotoxin-injected muscles[1].
IBS008738 (30 μM, 100 μL) prevents Dexamethasone-induced muscle atrophy[1].
IBS008738 (100-μL volume of 30 μM; intramuscular injection; immediately and on day 2 after TBI) diminishes the expression of TNF α and IL-6 but increases that of IL-10 mRNAs in muscles of traumatic brain injury (TBI)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old female BALB/cByJ mice[1]
Dosage: 3 nmol (0.3 μL of 10 mM IBS008738 was diluted in 100 μL of PBS)
Administration: Injected into the tibialis anterior (TA) muscle of mice under anesthesia.
Result: Facilitated muscle repair in Cardiotoxin-injected muscles.
Animal Model: Six-week-old female BALB/cByJ mice[1]
Dosage: 30 μM (100 μL)
Administration: Injected into the tibialis anterior (TA) and gastrocnemius (GM) muscles on days 9, 11, and 13.
Result: Prevented Dexamethasone-induced muscle atrophy.
Molecular Weight

374.44

Appearance

Solid

Formula

C22H22N4O2
CAS No.
SMILES

O=C(C1=C(/N=C/N2CCOCC2)N=CN1C3=CC=C(C)C=C3)C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (133.53 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6707 mL 13.3533 mL 26.7065 mL
5 mM 0.5341 mL 2.6707 mL 5.3413 mL
10 mM 0.2671 mL 1.3353 mL 2.6707 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (3.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (3.34 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.22%

COA (259 KB) HNMR (260 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References
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IBS008738 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

IBS008738385425-03-6IBS 008738IBS-008738Othersmuscle atrophymuscle injuryC2C12 cellsmyogenesisMyoD-dependent geneInhibitorinhibitorinhibit

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