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CALY

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1343

Inhibitors & Agonists

5

Screening Libraries

38

Fluorescent Dye

42

Biochemical Assay Reagents

119

Peptides

10

Inhibitory Antibodies

160

Natural
Products

91

Isotope-Labeled Compounds

6

Click Chemistry

38

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-103350
    CA-074
    25+ Cited Publications

    		 Cathepsin Neurological Disease Cancer
    CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
    CA-074
  • HY-111964
    Lenacapavir
    15+ Cited Publications

    GS-6207

    		 HIV Infection
    Lenacapavir (GS-6207) is an HIV-1 capsid inhibitor. Lenacapavir binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .
    Lenacapavir
  • HY-13513
    U-104
    5+ Cited Publications

    SLC-0111

    		 Carbonic Anhydrase Cancer
    U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model .
    U-104
  • HY-134923
    CA77.1
    5+ Cited Publications

    		 Autophagy Neurological Disease
    CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research .
    CA77.1
  • HY-B1424
    Benzthiazide
    2 Publications Verification

    		 Carbonic Anhydrase Cardiovascular Disease Cancer
    Benzthiazide is a long-acting diuretic and a hypertension agent. Benzthiazide is an inhibitor of carbonic anhydrase 9 (CA9), with Kis of 8.0, 8.8 and 10 nM for CA9, CA2 and CA1, respectively. Benzthiazide also suppresses proliferation of cancer cells .
    Benzthiazide
  • HY-17404
    Cilnidipine
    4 Publications Verification

    FRC-8653

    		 Calcium Channel Cardiovascular Disease
    Cilnidipine is a long-acting, second-generation dihydropyridine Ca 2+-channel blocker on L and N-type Ca 2+ channel . Antihypertensive effects .
    Cilnidipine
  • HY-101093
    CA-170
    2 Publications Verification

    		 PD-1/PD-L1 Inflammation/Immunology Cancer
    CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .
    CA-170
  • HY-100350
    CA-074 methyl ester
    35+ Cited Publications

    CA-074Me

    		 Cathepsin Neurological Disease Cancer
    CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
    CA-074 methyl ester
  • HY-129126
    NC9
    1 Publications Verification

    Cbz-Lys(Acr)-PEG2-dansyl

    		 Glutaminase Microtubule/Tubulin Others
    NC9 (Cbz-Lys(Acr)-PEG2-dansyl) is an irreversible transglutaminase (TG) inhibitor. NC9 inhibits osteoblast differentiation and mineralization. NC9 destabilizes microtubules. NC9 can be used for the research of osteoblast differentiation .
    NC9
  • HY-B0684
    Iopamidol
    3 Publications Verification

    B-15000; SQ-13396

    		 Biochemical Assay Reagents Cancer
    Iopamidol is a nonionic, X-Ray iodinated contrast agent (CA) for a wide variety of diagnostic applications. Iopamidol contains amide and hydroxyl functionalities that can be exploited for the generation of the chemical exchange saturation transfer (CEST) contrast .
    Iopamidol
  • HY-120072
    PF-3450074
    5 Publications Verification

    PF-74

    		 HIV Infection
    PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.
    PF-3450074
  • HY-136460
    Calcium ionophore I

    ETH 1001

    		 Calcium Channel Others
    Calcium ionophore I (ETH 1001) is a selective Ca 2+ ionophore for biological membranes. Calcium ionophore I can be used in Ca2+-selective microelectrodes that can be used for quantitative intracellular measurements of resting Ca2+-activities and of slowly changing Ca2+-levels .
    Calcium ionophore I
  • HY-112698
    CA-5f
    4 Publications Verification

    		 p62 Atg8/LC3 Autophagy Apoptosis Cancer
    CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity .
    CA-5f
  • HY-D1631
    Calcium Green-5N AM

    		Fluorescent Dye Calcium Channel Neurological Disease
    Calcium Green-5N AM is a Ca 2+-sensitive fluorescent probe (Kd = 14 μM). Calcium Green-5N AM shows enhanced fluorescence intensity upon binding to Ca 2+, and it can monitor free Ca 2+ in neurons .
    Calcium Green-5N AM
  • HY-118467
    Benzolamide
    2 Publications Verification

    CL11366

    		 Carbonic Anhydrase Neurological Disease Cancer
    Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures .
    Benzolamide
  • HY-110243
    CAIX Inhibitor S4
    1 Publications Verification

    		 Carbonic Anhydrase Cancer
    CAIX Inhibitor S4 is a potent and selective inhibitor of carbonic anhydrase IX/XII (CA IX/XII), with a Ki of 7 nM and 2 nM, respectively. CAIX Inhibitor S4 also inhibits CA II and CA I (Ki=546 and 5600 nM, respectively). CAIX Inhibitor S4 can inhibit the number of lung metastasis in orthotopic MDA-MB-231 mouse model without affecting primary tumor growth .
    CAIX Inhibitor S4
  • HY-111964A
    Lenacapavir sodium
    15+ Cited Publications

    GS-6207 sodium

    		 HIV Infection
    Lenacapavir (GS-6207) sodium is an HIV-1 capsid inhibitor. Lenacapavir sodium binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir sodium exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir sodium is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .
    Lenacapavir sodium
  • HY-P1075
    CALP3
    2 Publications Verification

    		 Calcium Channel Neurological Disease Cancer
    CALP3, a Ca 2+-like peptide, is a potent Ca 2+ channel blocker that activates EF hand motifs of Ca 2+-binding proteins. CALP3 can functionally mimic increased [Ca 2+]i by modulating the activity of Calmodulin (CaM), Ca 2+ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .
    CALP3
  • HY-104056
    Fura Red

    		Fluorescent Dye Others
    Fura Red is a Ca 2+-sensitive fluorescent dye, which decreases in fluorescence with rising [Ca 2+] .
    Fura Red
  • HY-103317
    NAADP

    		Nucleoside Antimetabolite/Analog Inflammation/Immunology
    NAADP, a nucleotide, is a Ca 2+-mobilizing second messenger. NAADP is essential for initiation of Ca 2+ signaling .
    NAADP
  • HY-18256
    Ombrabulin hydrochloride

    AVE8062 hydrochloride; AC7700 hydrochloride

    		 Microtubule/Tubulin Cardiovascular Disease Cancer
    Ombrabulin hydrochloride is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
    Ombrabulin hydrochloride
  • HY-14797
    Ombrabulin

    AVE8062; AC7700

    		 Microtubule/Tubulin Cardiovascular Disease Cancer
    Ombrabulin (AVE8062) is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
    Ombrabulin
  • HY-B2217D
    Calcium hydroxide, ACS, 95%

    		Bacterial Biochemical Assay Reagents Inflammation/Immunology
    Calcium hydroxide, ACS, 95% has high bactericidal activity and high pH. Calcium hydroxide, ACS, 95% has ability to induce hard tissue formation. Calcium hydroxide, ACS, 95% can dissociate into calcium (Ca) and hydroxyl ions (OH). Calcium hydroxide, ACS, 95% has the potential for intra-canal medicament research .
    Calcium hydroxide, ACS, 95%
  • HY-75161R
    (-)-Menthol (Standard)

    		Reference Standards TRP Channel Endogenous Metabolite Cancer
    (-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .
    (-)-Menthol (Standard)
  • HY-W749867
    Ca(II)-EDTA disodium dihydrate

    Calcium disodium EDTA dihydrate

    		 Bacterial Infection Others
    CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .
    Ca(II)-EDTA disodium dihydrate
  • HY-100298
    Caldaret

    MCC-135

    		 Na+/Ca2+ Exchanger Cardiovascular Disease
    Caldaret is an intracellular Ca 2+ handling modulator that acts through reverse mode Na +/Ca 2+ exchanger inhibition.
    Caldaret
  • HY-D1702
    Mag-Fura-2 tetrapotassium

    		Fluorescent Dye Others
    Mag-Fura-2 tetrapotassium is a cell-impermeant UV excitable rational fluorescent Mg 2+/Ca 2+ indicator (Ex=334-360 nm, Em=510 nm). Mag-Fura-2 tetrapotassium can be used for the determination of Mg 2+ and Ca 2+ concentrations .
    Mag-Fura-2 tetrapotassium
  • HY-100928
    YS 035 hydrochloride

    		Calcium Channel Neurological Disease
    YS 035 hydrochloride is a Ca 2+ antagonist on cellular uptake and mitochondrial efflux of calcium ions. YS 035 hydrochloride inhibits Ca 2+ uptake by muscle cells and inhibits Na +/Ca 2+ exchange (Ki=28 µM). YS 035 hydrochloride is a useful tool for research on the mitochondrial Ca 2+ transport .
    YS 035 hydrochloride
  • HY-P991649
    Anti-CA6 Antibody (huDS6)

    SAR566658 antibody

    		 Mucin ADC Antibody Cancer
    Anti-CA6 Antibody (huDS6) is a Mucin 1-associated sialoglycotope (CA6) targeting humanized monoclonal antibody. Anti-CA6 Antibody (huDS6) can be used for synthesis of ADCs .
    Anti-CA6 Antibody (huDS6)
  • HY-D1631A
    Calcium green-5N hexapotassium

    		Fluorescent Dye Neurological Disease
    Calcium green-5N hexapotassium is a cell-impermeant Ca 2+-sensitive fluorescent probe. Calcium green-5N hexapotassium shows enhancement in fluorescence intensity on binding Ca 2+, and can monitor free Ca 2+ in neurons .
    Calcium green-5N hexapotassium
  • HY-135110
    Rp-8-Br-cGMPS sodium
    1 Publications Verification

    Rp-8-bromo-Cyclic GMPS sodium

    		 Calcium Channel PKG HCN Channel Metabolic Disease
    Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca 2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca 2+ reduction by activating Ca 2+-ATPase and subsequently removing Ca 2+ from the cell .
    Rp-8-Br-cGMPS sodium
  • HY-123434
    PD-149164

    		Cholecystokinin Receptor Metabolic Disease Endocrinology
    PD-149164 is a potent agonist of cholecystokinin B (CCK-B) receptor, with IC50 values of 0.083 nM and 75 nM in binding assay to CCK-B and CCK-A .
    PD-149164
  • HY-U00354
    CP-060

    		Calcium Channel Cardiovascular Disease
    CP-​060 is a potent Ca 2+ antagonist, inhibits Ca 2+ overload and possesses antioxidant and cardioprotective activities.
    CP-060
  • HY-W170020
    PTCA

    		CaMK Metabolic Disease
    PTCA is a potent Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) ligand with a pKi value of 7.2 .
    PTCA
  • HY-P5422
    Caloxin 3A1

    		Calcium Channel Others
    Caloxin 3A1 is a biological active peptide. (This peptide belongs to caloxins, the extracellular plasma membrane (PM) Ca2+ pump inhibitors. Caloxin 3A1 inhibits plasma membrane calcium pumps (PMCAs) but not the sarcoplasmic reticulum Ca2+-pump. This peptide does not inhibit formation of the acylphosphate intermediate from ATP.)
    Caloxin 3A1
  • HY-CE01249
    CA-CoA

    CA-Coenzyme A

    		 Biochemical Assay Reagents Metabolic Disease
    CA-CoA (CA-Coenzyme A) is a coenzyme A derivative.
    CA-CoA
  • HY-162344
    Ir-CA

    		Apoptosis Autophagy Cancer
    Ir-CA is an antitumor agent. Ir-CA can accumulate in mitochondria and induces mitochondria dysfunction. Ir-CA induces apoptosis and autophagy. Ir-CA initiates mitophagy and cell cycle arrest to kill Cisplatin (HY-17394)-resistant A549R cells. Ir-CA can effectively inhibit metastasis by inhibiting MMP-2/MMP-9 .
    Ir-CA
  • HY-P11253
    DOTA-Bn-CA-170

    		VISTA Inflammation/Immunology
    DOTA-Bn-CA-170 is a molecular probe targeting the VISTA protein, with a Kd value of 0.124 nM. DOTA-Bn-CA-170 is formed by covalently linking the p-SCN-Bn-DOTA ligand with CA-170 (HY-101093). DOTA-Bn-CA-170 labeled with [ 68Ga]Ga successfully achieves specific and high-contrast PET imaging of VISTA expression in various tumor-bearing mouse models. DOTA-Bn-CA-170 can be used for the study of VISTA-targeted immunotherapy .
    DOTA-Bn-CA-170
  • HY-121516
    CM-TPMF

    		Potassium Channel Others
    CM-TPMF is a K(Ca)2 channel modulator with selective activation and inhibition of K(Ca)2.1 subtypes. CM-TPMF can act on K(Ca)2.1 channels as an activator or inhibitor, and its activity is affected by the stereochemical structure. It can be used to study the physiological or pathophysiological effects of K(Ca)2.1 channels.
    CM-TPMF
  • HY-17404S
    Cilnidipine-d7

    FRC-8653-d7

    		 Isotope-Labeled Compounds Calcium Channel Cardiovascular Disease
    Cilnidipine-d7 is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel . Antihypertensive effects .
    Cilnidipine-d7
  • HY-13764R
    Tetrandrine (Standard)

    NSC-77037 (Standard); d-Tetrandrine (Standard)

    		 Reference Standards Calcium Channel Potassium Channel Parasite Inflammation/Immunology Cancer
    Tetrandrine (Standard) is the analytical standard of Tetrandrine. This product is intended for research and analytical applications. Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.
    Tetrandrine (Standard)
  • HY-D1636
    5-Nitro BAPTA

    		Fluorescent Dye Others
    5-Nitro BAPTA is a calcium chelator, combinded with 2-Me-substituted TM ( as a fluorescent moiety), can be used to form a red fluorescent probe (CaTM-2 AM), for imaging of cytoplasmic Ca 2+ in cultured living cells. 5-Nitro BAPTA is a building block used in the synthesis of Ca 2+ specific chelators, Ca 2+ buffers, and fluorescent Ca 2+ indicators .
    5-Nitro BAPTA
  • HY-D1424
    Coelenterazine hcp

    		Fluorescent Dye Others
    Coelenterazine hcp is a Coelenterazine analogue. Coelenterazine hcp shows high sensitivity to Ca 2+. Coelenterazine hcp is suited for monitoring intracellular Ca 2+ .
    Coelenterazine hcp
  • HY-12550
    GW542573X

    		Potassium Channel Neurological Disease
    GW542573X is a potent and selective Ca 2+-activated K + 2 (SK2) channels activator. GW542573X induces the Ca 2+-response curve of hSK1 that left-shifted from an EC50 (Ca 2+) value of 410 nM to 240 nM .
    GW542573X
  • HY-174232
    EGFR/CA-IX-IN-1

    		EGFR Carbonic Anhydrase Caspase Cancer
    EGFR/CA-IX-IN-1 (Compound 14) is a dual inhibitor against epidermal growth factor receptor (EGFR) and carbonic anhydrase IX (CA-IX) with IC50 values of 5.92 nM and 63 nM, respectively. EGFR/CA-IX-IN-1 shows strong cytotoxicity against breast cancer cells (MDA-MB-231, MCF-7) with IC50 values of 5.78 μM and 8.05 μM, respectively. EGFR/CA-IX-IN-1 inhibits the catalytic activity of CA-IX, up-regulates BAX/Bcl-2, activates caspases, and arrests the cell cycle at the G1 phase. EGFR/CA-IX-IN-1 is promising for research of breast cancer .
    EGFR/CA-IX-IN-1
  • HY-RS01850
    CALY Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CALY Human Pre-designed siRNA Set A contains three designed siRNAs for CALY gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CALY Human Pre-designed siRNA Set A
    CALY Human Pre-designed siRNA Set A
  • HY-W424792A
    O-Desmethyl Brinzolamide hydrochloride

    		Carbonic Anhydrase Drug Metabolite Neurological Disease
    O-Desmethyl Brinzolamide hydrochloride (compound 6a), an active metabolite of Brinzolamide, is a carbonic anhydrase (CA) inhibitor with a Kd of 0.136 nM for CA II and an IC50 of 165 nM for CA IV .
    O-Desmethyl Brinzolamide hydrochloride
  • HY-146252
    hCAXII-IN-4

    		Carbonic Anhydrase Cancer
    hCAXII-IN-4 (compound 5j) is a potent and selective CA XII inhibitor with an Ki value of 6.4 nM for human CA XII .
    hCAXII-IN-4
  • HY-B1558
    Bifemelane

    MCI-2016 free base

    		 Calcium Channel Neurological Disease
    Bifemelane is a nootropic compound. Bifemelan causes the first peak by stimulating release from intracellular Ca 2+ stores and the second by capacitive entry through store–operated Ca 2+ channels. Bifemelane will be provided as a pharmacological tool for basic studies on astrocytes .
    Bifemelane
  • HY-178475
    CA IX/GPX4-IN-1

    		Carbonic Anhydrase Glutathione Peroxidase Ferroptosis Cancer
    CA IX/GPX4-IN-1 (Compound 22abcb) is a dual targeted inhibitor of CA IX and GPX4 activity. CA IX/GPX4-IN-1 can effectively kill SUM159PT cells (IC50 = 416 nM) by inducing iron death under hypoxic conditions. CA IX/GPX4-IN-1 has an IC50 of 663 nM to CA IX in SUM159PT-CAIX-FL cells. CA IX/GPX4-IN-1 can significantly inhibit tumor growth and can be reversed by ferroptosis inhibitors. CA IX/GPX4-IN-1 can be used for research on breast cancer and other cancers .
    CA IX/GPX4-IN-1

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