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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
CRBN ligand1
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "CRBN ligand1" in MCE Product Catalog:
Cat. No.: HY-150799
CAS No.: 3032314-67-0
Target:
Research Areas:
CRBN ligand-1 is a ligand for E3 ligase.
Cat. No.: HY-W453397
CAS No.: 1892461-96-9
Research Areas:
Aberrant tau ligand 1 is a tau protein ligand. Aberrant tau ligand 1 engages tau and CRBN to trigger proteasomal degradation. Aberrant tau ligand 1 can be used for synthesis PROTACs, such as QC-01–175 (HY-134850) .
Cat. No.: HY-170820
CAS No.: 3006788-11-7
Target:
Molecular Glues Eukaryotic Release Factor (eRF) Bcl-2 Family CDK EGFR HSP Androgen Receptor c-Myc
Research Areas:
XYD049 is a CRBN-based molecular glue degrader targeting GSPT1, with a DC50 of 19 nM. XYD049 mediates the formation of a ternary complex between CRBN and GSPT1, thereby triggering CRBN- and proteasome-dependent degradation of GSPT1. By degrading GSPT1, XYD049 downregulates castration-resistant prostate cancer (CRPC)-related oncogenes, including BCL2, CDK2, E2F3, EGFR, HSP90B1, TMPRSS2, AR, AR-V7, PSA and c-Myc. XYD049 inhibits cancer cell growth and suppresses tumor growth in mice. XYD049 can be used for research on castration-resistant prostate cancer. XYD049 consists of a linker (black part) NH2-C5-NH-Boc (HY-W004710), a CRBN-based E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a target protein ligand (red part) GSPT1 ligand-1 (HY-170821), among which the E3 ligase ligand plus linker forms the conjugate E3 Ligase Ligand-linker Conjugate 158 (HY-170822) .
Cat. No.: HY-163922
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CRBN ligand-1-piperidine-Me is an E3 ligase ligand-linker conjugate.
Cat. No.: HY-141486
CAS No.: 2935073-36-0
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(Rac)-PROTAC PARP/EGFR ligand 1 incorporates a ligand for PARP and EGFR , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). (Rac)-PROTAC PARP/EGFR ligand 1 can be used in the synthesis of DP-C-4, which is CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP .
Cat. No.: HY-172954
CAS No.: 3077430-87-3
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Androgen receptor ligand 1 is an androgen receptor (AR) ligand. Androgen receptor ligand 1 binds to CRBN E3 ligase via a linker to form an AR PROTAC degrader. Androgen receptor ligand 1 can be used in the study of prostate cancer .
Cat. No.: HY-183011
CAS No.: 2953426-96-3
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CRBN ligand-901 (5d in Scheme 2) is a ligand for Cereblon (CRBN). CRBN ligand-901 can be linked to target protein ligands (e.g., VP1 ligand-1) via a linker to form PROTAC molecules (e.g., Jun15702 (HY-182924)) .
Cat. No.: HY-180179
Research Areas:
BLIMP-1 Ligand-Linker Conjugate 1 is a conjugate of BLIMP-1 Ligand-1 (HY-180178) and Linker (HY-180180). BLIMP-1 ligand-Linker Conjugate 1 can be coupled with CRBN ligand-881 (HY-W442918) to form PROTAC BLIMP-1 degrader-1 (HY-180177) .
Cat. No.: HY-182085
CAS No.: 3039540-25-2
Research Areas:
E3 Ligase Ligand-Linker Conjugate 227 is an E3 ligase ligand-linker conjugate containing CRBN ligand-1 (HY-150799) and a linker (HY-W262798). E3 Ligase Ligand-linker Conjugate 227 can be linked to the target protein ligand BRD9 ligand-12 (HY-182084) to form a PROTAC molecule, XYD270 (HY-182082) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
