2935073-36-0
Chemical Structure
(Rac)-PROTAC PARP/EGFR ligand 1
- CAS No.: 2935073-36-0
- Formula:C53H56ClF2N9O8
- Molecular Weight:1020.52
IUPAC Name: 6-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-(1-((6-(4-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoyl)piperazin-1-yl)-6-oxohexyl)amino)-1-oxo-3-(prop-2-yn-1-yloxy)propan-2-yl)hexanamide
InChIKey: BNDSNLWRYZUWNY-UHFFFAOYSA-N
SMILES: O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCNC(C(COCC#C)NC(CCCCCOC4=CC5=C(NC6=CC=C(C(Cl)=C6)F)N=CN=C5C=C4OC)=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7
Biological Activity: (Rac)-PROTAC PARP/EGFR ligand 1 incorporates a ligand for PARP and EGFR , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). (Rac)-PROTAC PARP/EGFR ligand 1 can be used in the synthesis of DP-C-4, which is CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP[1].
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(Rac)-PROTAC PARP/EGFR ligand 1 | (Rac)-PROTAC PARP/EGFR ligand 1 incorporates a ligand for PARP and EGFR , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). (Rac)-PROTAC PARP/EGFR ligand 1 can be used in the synthesis of DP-C-4, which is CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP. | |||||||||||||||||||||
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