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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
334 Results for "
CXCR
" in MedChemExpress (MCE) Product Catalog:
Products (334)
334 Results for "CXCR" in MCE Product Catalog:
111
111 Publications Verification
Referencia número: HY-50912
No. CAS: 155148-31-5
Synonyms: AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride
Target:
Áreas de investigación:
Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM.
111
111 Publications Verification
Synonyms: AMD 3100; JM3100; SID791
Áreas de investigación:
Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM .
65
65 Cited Publications
Referencia número: HY-16711
No. CAS: 182498-32-4
Target:
Áreas de investigación:
SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM.
63
63 Cited Publications
Synonyms: Repertaxin L-lysine salt
Target:
Áreas de investigación:
Reparixin L-lysine salt is an allosteric inhibitor of chemokine receptor 1/2 (CXCR1/2) activation.
63
63 Cited Publications
Synonyms: Repertaxin; DF 1681Y
Target:
Áreas de investigación:
Reparixin is a non-competitive allosteric inhibitor of the chemokine receptors CXCR1 and CXCR2 activation with IC50s of 1 and 100 nM, respectively.
40
40 Cited Publications
Target:
Áreas de investigación:
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively .
32
32 Cited Publications
Synonyms: SCH 527123; MK-7123
Target:
Áreas de investigación:
Navarixin (SCH 527123) is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly .
28
28 Cited Publications
Synonyms: ZK-811752
Target:
Áreas de investigación:
BX471 (ZK-811752) is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
28
28 Cited Publications
Synonyms: ZK-811752 hydrochloride
Target:
Áreas de investigación:
BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
24
24 Cited Publications
Synonyms: AZD8797; KAND567
Áreas de investigación:
AZD8797 (KAND567) is an allosteric non-competitive and orally active antagonist of the human CX3CR1 receptor; antagonizes CX3CR1 and CXCR2 with Kis of 3.9 and 2800 nM, respectively .
19
19 Cited Publications
Target:
Áreas de investigación:
SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
18
18 Cited Publications
Referencia número: HY-N0011
No. CAS: 113558-15-9
Synonyms: Icariin-II; Icariside-II
13
13 Cited Publications
Target:
Áreas de investigación:
13
13 Cited Publications
Synonyms: Takeda 779
Áreas de investigación:
TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.
11
11 Cited Publications
Synonyms: Quinurenic acid
Category:
Alkaloids Human Gut Microbiota Metabolites Neurological Disease Quinoline Alkaloids Endogenous metabolite Disease Research Fields Endocrinology
Target:
11
Category:
Alkaloids Quinoline Alkaloids Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
10
10 Cited Publications
Target:
Áreas de investigación:
SX-682 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity .
10
10 Cited Publications
Referencia número: HY-19855
No. CAS: 878385-84-3
Target:
Áreas de investigación:
AZD-5069 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment.
9
Target:
Áreas de investigación:
Danirixin is a selective, and reversible CXCR2 antagonist, with IC50?of?12.5 nM for CXCL8.
9
9 Cited Publications
Target:
Áreas de investigación:
NBI-74330 is a potent antagonist for CXCR3, and exhibits potent inhibition of ( 125I)CXCL10 and ( 125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
