473719-41-4
473719-41-4
Chemical Structure
AMG 487
- CAS No.: 473719-41-4
- Formula:C32H28F3N5O4
- Molecular Weight:603.59
IUPAC Name: (R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide
InChIKey: WQTKNBPCJKRYPA-OAQYLSRUSA-N
SMILES: O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5
Biological Activity: AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively[1].
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AMG 487 | 99.89% | AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. | ||||||||||||||||||||
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AMG 487 (Standard) | ≥98% | AMG 487 (Standard) is the analytical standard of AMG 487 (HY-15319). This product is intended for research and analytical applications. AMG 487 is an orally active and selective antagonist of CXC chemoKine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-15319A(±)-AMG 487 -
Similarity Score 1.00
HY-15319BAMG 487 (S-enantiomer) -
Similarity Score 0.85
HY-110099(±)-NBI-74330 -
Similarity Score 0.85
HY-15320NBI-74330 -
Similarity Score 0.51
HY-150622SARS-CoV-2 nsp13-IN-1 -
Similarity Score 0.50
HY-15763Erastin -
Similarity Score 0.49
HY-114481Imidazole ketone erastin -
Similarity Score 0.48
HY-139087Erastin2 -
Similarity Score 0.48
HY-120797CRT0273750 -
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